The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Prenatal stress modifies hippocampal synaptic plasticity and spatial learning in young rat offspring
Abstract
Clinical studies demonstrate that prenatal stress causes cognitive deficits and increases vulnerability to affective disorders in children and adolescents. The underlying mechanisms are not yet fully understood. Here, we reported that prenatal stress (10 unpredictable, 1 s, 0.8 mA foot shocks per day during gestational days 13-19) impaired long-term potentiation (LTP) but facilitated long-term depression (LTD) in hippocampal CA1 region in slices of the prenatal stressed offspring (5 weeks old). Cross-fostering neonate offspring by the prenatal stressed or control mothers did not change the effects of prenatal stress on the hippocampal LTP and LTD. Furthermore, prenatal stress enhanced the effects of acute stress on the hippocampal LTP and LTD and impaired spatial learning and memory in the Morris water maze in the young rat offspring. Therefore, prenatal stress alters synaptic plasticity and enhances the effects of acute stress on synaptic plasticity in the hippocampus, which may be the mechanism for the impaired spatial learning and memory in young rat offspring.
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Cites
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The stressed hippocampus, synaptic plasticity and lost memories
Kim, J. J., & Diamond, D. M. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn849 · Cited by 1,543
Stress and glucocorticoids impair retrieval of long-term spatial memory
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“…including NMDA receptor NR1 and NR2A subunits, densin180, guanylate kinase-associated protein, synaptosome associated protein, and vesicle-associated membrane protein 2 (Kinnunen et al., 2003), and also reducing the number of granule neurons and hippocampal neurogenesis (Lemaire et al., 2000).”
BackgroundAlterations induced by gestational stress in brain morphology and behaviour of the offspring
Weinstock, M. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00018-1 · Cited by 791
Inescapable versus escapable shock modulates long-term potentiation in the rat hippocampus
Shors, T. J., Seib, T. B., Levine, S., & Thompson, R. F. (1989) · Science · doi:10.1126/science.2704997 · Cited by 458
Cited by
Stress effects on memory: An update and integration
Schwabe, L., Joëls, M., Roozendaal, B., Wolf, O. T., & Oitzl, M. S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.07.002 · Cited by 714
Gender Differences in the Effects of Prenatal Stress on Brain Development and Behaviour
Weinstock, M. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9339-4 · Cited by 349
Prenatal stress: Role in psychotic and depressive diseases
Markham, J. A., & Koenig, J. I. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2035-0 · Cited by 274
Prenatal stressors in rodents: Effects on behavior
Weinstock, M. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.08.004 · Cited by 264
Monk, C., Georgieff, M. K., & Osterholm, E. A. (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12000 · Cited by 258
Metadata
- Authors
- Yang, J., Han, H., Cao, J., Li, L., & Xu, L.
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 2006
- Volume
- 16
- Issue
- 5
- Pages
- 431-436
- ISSN
- 1050-9631 (ISSN-L)
- 1098-1063
- OpenAlex
- W2081125623
- Cited by
- 161
- References
- 6
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- closed
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