Inescapable versus escapable shock modulates long-term potentiation in the rat hippocampus

Shors, Tracey J.; Seib, Thomas B.; Levine, Seymour; Thompson, Richard F.

doi:10.1126/science.2704997

Cited by 458Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchStress Responses and Cortisol

Inescapable versus escapable shock modulates long-term potentiation in the rat hippocampus

Shors, Tracey J., Seib, Thomas B., Levine, Seymour, Thompson, Richard F.·1989·Science

DOI 10.1126/science.2704997

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Abstract

A group of rats was trained to escape low-intensity shock in a shuttle-box test, while another group of yoked controls could not escape but was exposed to the same amount and regime of shock. After 1 week of training, long-term potentiation (LTP) was measured in vitro in hippocampal slices. Exposure to uncontrollable shock massively impaired LTP relative to exposure to the same amount and regime of controllable shock. These results provide evidence that controllability modulates plasticity at the cellular-neuronal level.

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The defensive escape response has to be prevented; only then do trauma symptoms develop.
“The defensive escape response has to be prevented; only then do trauma symptoms develop (Shors et al., 1989).”
From Somatic experiencing: using interoception and proprioception as core elements of trauma therapy (2015) · cites this paper as Shors et al., 1989

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Authors: Shors, T. J., Seib, T. B., Levine, S., & Thompson, R. F.
Affiliations: University of Southern California (US)
Stanford Medicine (US)
ORCID: Shors, Tracey J.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1989-04-14
Volume: 244
Issue: 4901
Pages: 224-226
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.2704997
OpenAlex: W1992704051
Semantic Scholar: 9dc21f7f365e807e2f4a7e24da61342b6bbc8a06
Cited by: 458
References: 42
Citations by year: 2025: 5 · 2024: 7 · 2023: 4 · 2022: 8 · 2021: 7 · 2020: 13 · 2019: 16 · 2018: 10 · 2017: 4 · 2016: 8 · 2015: 21 · 2014: 19 · 2013: 12 · 2012: 21
FWCI: 5.71
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH11936)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 02881)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: long-term potentiation, hippocampus, escapable shock, controllability, hippocampal plasticity, shuttlebox avoidance, inescapable stress, neuroplasticity
MeSH terms: Animals, Avoidance Learning, Corticosterone, Electroshock, Escape Reaction, Hippocampus, Learning, Male, Memory, Neuronal Plasticity, Stress, Psychological, Rats

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Inescapable versus escapable shock modulates long-term potentiation in the rat hippocampus

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