Stress and glucocorticoids impair retrieval of long-term spatial memory
Abstract
Extensive evidence from animal and human studies indicates that stress and glucocorticoids influence cognitive function. Previous studies have focused exclusively on glucocorticoid effects on acquisition and long-term storage of newly acquired information. Here we report that stress and glucocorticoids also affect memory retrieval. We show that rats have impaired performance in a water-maze spatial task after being given footshock 30 min before retention testing but are not impaired when footshock is given 2 min or 4 h before testing. These time-dependent effects on retention performance correspond to the circulating corticosterone levels at the time of testing, which suggests that the retention impairment is directly related to increased adrenocortical function. In support of this idea, we find that suppression of corticosterone synthesis with metyrapone blocks the stress-induced retention impairment. In addition, systemic corticosterone administered to non-stressed rats 30 min before retention testing induces dose-dependent retention impairment. The impairing effects of stress and glucocorticoids on retention are not due to disruption of spatial navigation per se. Our results indicate that besides the well described effects of stress and glucocorticoids on acquisition and consolidation processes, glucocorticoids also affect memory retrieval mechanisms.
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Acute stress or corticosterone can impair hippocampus-specific memory processing in rats and people.
“and can impair hippocampus-specific memory processing in rats (de Quervain et al. [157]; Conrad et al. [158]; Roozendaal et al. [159]) and people (Kirschbaum et al. [160]; de Quervain et al. [161]; Wolf et al. [162]; Payne et al. [163]; Buss et al. [164]; Wolf et al. [165]; Elzinga et al. [76]; Kuhlmann et al. [166]; Kuhlmann et al. [167]; Payne et al. [168]; Buchanan”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as de Quervain et al. [157]
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- Authors
- de Quervain, D. J.-F., Roozendaal, B., & McGaugh, J. L.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Roozendaal, Benno
- ORCID
- Roozendaal, Benno
- Venue
- Nature
- Published
- 1998-08
- Volume
- 394
- Issue
- 6695
- Pages
- 787-790
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1724698019
- Cited by
- 1,182
- References
- 22
- Citations by year
- 2026: 28 · 2025: 21 · 2024: 27 · 2023: 15 · 2022: 26 · 2021: 25 · 2020: 37 · 2019: 39 · 2018: 52 · 2017: 51 · 2016: 46 · 2015: 47 · 2014: 54 · 2013: 73 · 2012: 58
- FWCI
- 17.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- stress, glucocorticoids, corticosterone, memory retrieval, long-term spatial memory, water maze, footshock, metyrapone, adrenocortical function, memory consolidation, memory acquisition, spatial navigation
- MeSH terms
- Animals, Glucocorticoids, Hypothalamo-Hypophyseal System, Male, Memory Disorders, Pituitary-Adrenal System, Retention, Psychology, Stress, Physiological, Rats, Sprague-Dawley, Maze Learning, Rats
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