The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Onset of hippocampus-dependent memory impairments in 5XFAD transgenic mouse model of Alzheimer’s disease
Abstract
The 5XFAD mice are an early‐onset transgenic model of Alzheimer's disease (AD) in which amyloid plaques are first observed between two and four months of age in the cortical layer five and in the subiculum of the hippocampal formation. Although cognitive alterations have been described in these mice, there are no studies that focused on the onset of hippocampus‐dependent memory deficits, which are a hallmark of the prodromal stage of AD. To identify when the first learning and memory impairments appear, 5XFAD mice of two, four, and six months of age were compared with their respective wild‐type littermates using the olfactory tubing maze, which is a very sensitive hippocampal‐dependent task. Deficits in learning and memory started at four months with a substantial increase at six months of age while no olfactory impairments were observed. The volumetric study using magnetic resonance imaging of the whole brain and specific areas (olfactory bulb, striatum, and hippocampus) did not reveal neuro‐anatomical difference. Slight memory deficits appeared at 4 months of age in correlation with an increased astrogliosis and amyloid plaque formation. This early impairment in learning and memory related to the hippocampal dysfunction is particularly suited to assess preclinical therapeutic strategies aiming to delay or suppress the onset of AD. © 2014 Wiley Periodicals, Inc.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Interestingly, behavioral and memory deficits do not typically begin to show significant differences in 5xFAD animals until at least 5-7 months of age (Girard et al., 2014; Ohno, 2009).”
From LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease (2019) · cites this paper as Girard et al., 2014
Citations
Cites
The mouse brain in stereotaxic coordinates
Konsman, J. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(03)00088-x · Cited by 16,796
Abràmoff, M. D., Magalhães, P. J., & Ram, S. J. (2004) · Utrecht University Repository (Utrecht University) · Cited by 11,816
Oakley, H., Cole, S. L., Logan, S., Maus, E., Shao, P., Craft, J., Guillozet-Bongaarts, A., Ohno, M., Disterhoft, J., Van Eldik, L., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1202-06.2006 · Cited by 3,530 · cited 5×
“…take at least 6–12 months to form amyloid plaques (Eriksen and Janus, 2007), the 5XFAD transgenic mice used in this study are one of the most early onset and aggressive amyloid mouse models with a development starting at two months of age (Oakley et al., 2006; Ohno et al., 2006, 2007; Ohno, 2009).”
BackgroundMethodResultInfluentialImpaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
Chapman, P. F., White, G. L., Jones, M. W., Cooper-Blacketer, D., Marshall, V. J., Irizarry, M., Younkin, L., Good, M. A., Bliss, T. V. P., Hyman, B. T., et al. (1999) · Nature Neuroscience · doi:10.1038/6374 · Cited by 946
Animal models of Alzheimer's disease and frontotemporal dementia
Götz, J., & Ittner, L. M. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2420 · Cited by 676
Jawhar, S., Trawicka, A., Jenneckens, C., Bayer, T. A., & Wirths, O. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.05.027 · Cited by 623 · cited 2×
“This finding is in agreement with a recent report demonstrating with unbiased stereology that 5XFAD mice develop a significant selective neuron loss in layer five of the cortex from 12 months of age but the overall neuron number in the entire frontal cortex and hippocampus was unaffected (Jawhar et al., 2012).”
ResultMemory and Brain Systems: 1969–2009
Squire, L. R. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3575-09.2009 · Cited by 550
Ohno, M., Sametsky, E. A., Younkin, L. H., Oakley, H., Younkin, S. G., Citron, M., Vassar, R., & Disterhoft, J. F. (2004) · Neuron · doi:10.1016/s0896-6273(03)00810-9 · Cited by 549
Exercise, experience and the aging brain1
Churchill, J. D., Galvez, R., Colcombe, S. J., Swain, R. A., Kramer, A. F., & Greenough, W. T. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00028-3 · Cited by 549
Brain plasticity and functional losses in the aged: scientific bases for a novel intervention
Mahncke, H. W., Bronstone, A. B., & Merzenich, M. M. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)57006-2 · Cited by 538
Flagged first, then by citations
Research works printed but not linked: 1
- O'leary TP, 2011, Poster presented at the 41st annual meeting of the Society for Neuroscience
Cited by
Sorted by citations
Heckmann, B. L., Teubner, B. J. W., Tummers, B., Boada-Romero, E., Harris, L., Yang, M., Guy, C. S., Zakharenko, S. S., & Green, D. R. (2019) · Cell · doi:10.1016/j.cell.2019.05.056 · Cited by 503
“Interestingly, behavioral and memory deficits do not typically begin to show significant differences in 5xFAD animals until at least 5-7 months of age (Girard et al., 2014; Ohno, 2009).”
Landel, V., Baranger, K., Virard, I., Loriod, B., Khrestchatisky, M., Rivera, S., Benech, P., & Féron, F. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-33 · Cited by 176
Self-citationBaranger, K., Marchalant, Y., Bonnet, A. E., Crouzin, N., Carrete, A., Paumier, J.-M., Py, N. A., Bernard, A., Bauer, C., Charrat, E., et al. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1992-1 · Cited by 133
Self-citationSex Differences in Behavior and Molecular Pathology in the 5XFAD Model
Sil, A., Erfani, A., Lamb, N., Copland, R., Riedel, G., & Platt, B. (2022) · Journal of Alzheimer's Disease · doi:10.3233/jad-210523 · Cited by 109
Rivera, S., García-González, L., Khrestchatisky, M., & Baranger, K. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03178-2 · Cited by 111
Self-citation
Metadata
- Authors
- Girard, S. D., Jacquet, M., Baranger, K., Migliorati, M., Escoffier, G., Bernard, A., Khrestchatisky, M., Féron, F., Rivera, S., Roman, F. S., & Marchetti, E.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Aix Marseille Université, CNRS, NICN, UMR7259 Marseille France
- Corresponding author
- Roman, François S.
- ORCID
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 2014-03-14
- Volume
- 24
- Issue
- 7
- Pages
- 762-772
- ISSN
- 1050-9631 (ISSN-L)
- 1098-1063
- OpenAlex
- W1532925865
- Cited by
- 119
- References
- 42
- Citations by year
- 2026: 13 · 2025: 7 · 2024: 13 · 2023: 13 · 2022: 22 · 2021: 14 · 2020: 5 · 2019: 9 · 2018: 8 · 2017: 5 · 2016: 3 · 2015: 3 · 2014: 4
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hippocampus (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- 5xFAD mice, Alzheimer's disease, hippocampal-dependent memory, learning and memory impairment, prodromal Alzheimer's disease, amyloid plaques, astrocyte activation, olfactory bulb, hippocampal dysfunction
- MeSH terms
- Alzheimer Disease, Animals, Astrocytes, Corpus Striatum, Gliosis, Hippocampus, Learning Disabilities, Magnetic Resonance Imaging, Male, Memory Disorders, Mice, Transgenic, Olfactory Bulb, Organ Size, Smell, Amyloid beta-Protein Precursor, Point Mutation, Age of Onset, Maze Learning, Mice, Presenilin-1, Plaque, Amyloid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
