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Neuronal activity in the hippocampus during delayed non‐match to sample performance in rats: Evidence for hippocampal processing in recognition memory

Otto, Tim, Eichenbaum, Howard·1992·Hippocampus

DOI 10.1002/hipo.450020310

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Abstract

Neuronal activity in the CA1 of rats was explored with regard to functional correlates of performance in an odor‐guided continuous delayed non‐match to sample task. Although different CA1 cells fired in association with each identifiable trial event, these analyses focused on cells that fired selectively during the period of odor cue sampling and response generation. The firing patterns of many of these cells reflected the match or non‐match comparison between current and previous odor cues independent of the particular stimuli that composed those comparisons. Such cells were more prevalent in sessions when performance was highly accurate. Hippocampal cells did not demonstrate stimulus‐evoked firing that persisted through the memory delay, nor did they fire differentially to session‐novel vs. repeated odor presentations. These results suggest that the hippocampus contributes to recognition memory by processing comparisons between current information and representations of previous stimuli stored in parahippocampal and neocortical structures.

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“Units have been shown to be selective for the receipt of reward at a particular location (Wiener et al., 1989), and rewarddependent responses have been shown in both region CA1 (Otto & Eichenbaum , 1992) and entorhinal cortex (Young et al., 1997).”
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Authors: Otto, T., & Eichenbaum, H.
Affiliations: University of North Carolina at Chapel Hill (US)
Corresponding author: Otto, Tim
ORCID: Eichenbaum, Howard
Venue: Hippocampus
Publisher: Wiley
Published: 1992-07
Volume: 2
Issue: 3
Pages: 323-334
ISSN: 1050-9631 (ISSN-L)
1098-1063
DOI: 10.1002/hipo.450020310
OpenAlex: W2117977220
Cited by: 232
References: 58
Citations by year: 2026: 1 · 2025: 1 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 7 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 7 · 2013: 8 · 2012: 5
FWCI: 9.23
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4487 d)
Locations: Hippocampus (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation
National Institutes of Health (7r01ns026402-04)
National Institute on Aging (NIA AG09973)
National Institute of Neurological Disorders and Stroke (NS26402)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: hippocampal CA1, neuronal firing patterns, recognition memory, odor-guided behavior, memory comparison
MeSH terms: Animals, Evoked Potentials, Hippocampus, Male, Memory, Neurons, Odorants, Psychomotor Performance, Pyramidal Tracts, Reward, Time Factors, Rats

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Neuronal activity in the hippocampus during delayed non‐match to sample performance in rats: Evidence for hippocampal processing in recognition memory

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