A Neural Mechanism for Working and Recognition Memory in Inferior Temporal Cortex

Miller, Earl K.; Li, Lin; Desimone, Robert

doi:10.1126/science.1962197

Cited by 706Memory and Neural MechanismsVisual perception and processing mechanismsMemory Processes and Influences

A Neural Mechanism for Working and Recognition Memory in Inferior Temporal Cortex

Miller, Earl K., Li, Lin, Desimone, Robert·1991·Science

DOI 10.1126/science.1962197

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Abstract

Inferior temporal (IT) cortex is critical for visual memory, but it is not known how IT neurons retain memories while new information is streaming into the visual system. Single neurons were therefore recorded from IT cortex of two rhesus monkeys performing tasks that required them to hold items in memory while concurrently viewing other items. The neuronal response to an incoming visual stimulus was attenuated if it matched a stimulus actively held in working memory, even when several other stimuli intervened. The neuronal response to novel stimuli declined as the stimuli became familiar to the animal. IT neurons appear to function as adaptive mnemonic "filters" that preferentially pass information about new, unexpected, or not recently seen stimuli.

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Authors: Miller, E. K., Li, L., & Desimone, R.
Affiliations: National Institutes of Health (US)
ORCID: Miller, Earl K.
Li, Lin
Desimone, Robert
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1991-11-29
Volume: 254
Issue: 5036
Pages: 1377-1379
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1962197
OpenAlex: W2053315601
Cited by: 706
References: 15
Citations by year: 2026: 12 · 2025: 7 · 2024: 10 · 2023: 15 · 2022: 10 · 2021: 15 · 2020: 13 · 2019: 19 · 2018: 19 · 2017: 18 · 2016: 25 · 2015: 19 · 2014: 22 · 2013: 22 · 2012: 21
FWCI: 19.67
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords: inferior temporal cortex, working memory, recognition memory, visual memory, single-unit recording, rhesus monkeys, memory maintenance, stimulus familiarity
MeSH terms: Analysis of Variance, Animals, Learning, Macaca mulatta, Memory, Neurons, Reaction Time, Temporal Lobe, Visual Pathways

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A Neural Mechanism for Working and Recognition Memory in Inferior Temporal Cortex

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