The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Effects of glucocorticoids on hippocampal long‐term potentiation
Abstract
The effects of chronic and acute corticosterone (CORT) administration were investigated on hippocampal long‐term potentiation (LTP) in the dentate gyrus granule cell layer of the rat. Electrophysiological experiments were performed in vivo under urethane anesthesia. Chronic CORT treatment (40 mg/kg/day) over 21 days decreased LTP compared to vehicle controls, even when LTP was measured 48 hours after cessation of CORT treatment, when serum CORT levels had returned to baseline. A single injection of CORT also decreased LTP compared to vehicle controls, but only when CORT levels were high, since at 48 hours after a single acute CORT injection LTP was not depressed. The decrements in LTP were seen both for the slope of the excitatory postsynaptic potential and for the population spike. Yet CORT had no effects on posttetanic potentiation or neuronal excitability. These findings are consistent with previous reports showing a reduction in LTP in the CAI field of animals exposed to stress or acute CORT administration.
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“Conversely, stress levels of corticosterone applied for a longer period of time (>20 minutes) increased the magnitude of inhibitory components of electrophysiological activity, such as the afterhyperpolarization (Joëls and de Kloet [233]; Kerr et al. [234]; Joëls and de Kloet [235]; Karst and Joëls [236]), and suppressed the induction of LTP (Pavlides et al. [237]; Rey et al. [238]; Kerr et al. [”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Pavlides et al. [237]
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Self-citationStress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons
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Self-citationHippocampal damage associated with prolonged glucocorticoid exposure in primates
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Selective Loss of Hippocampal Granule Cells in the Mature Rat Brain After Adrenalectomy
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Inescapable versus escapable shock modulates long-term potentiation in the rat hippocampus
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Research works printed but not linked: 1
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Sorted by citations
Sapolsky, R. M., Romero, L. M., & Munck, A. U. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.1.0389 · Cited by 7,541
Brain corticosteroid receptor balance in health and disease
de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614
Long-Term Potentiation and Memory
Lynch, M. A. (2004) · Physiological Reviews · doi:10.1152/physrev.00014.2003 · Cited by 2,074
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Metadata
- Authors
- Pavlides, C., Watanabe, Y., & McEwen, B. S.
- Affiliations
- Rockefeller University (US)
- Corresponding author
- Pavlides, Constantine
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 1993-04
- Volume
- 3
- Issue
- 2
- Pages
- 183-192
- ISSN
- 1050-9631 (ISSN-L)
- 1098-1063
- OpenAlex
- W2046273515
- Cited by
- 323
- References
- 61
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 2 · 2022: 6 · 2021: 12 · 2020: 7 · 2019: 7 · 2018: 12 · 2017: 7 · 2016: 4 · 2015: 7 · 2014: 13 · 2013: 8 · 2012: 13
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hippocampus (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Whitehall Foundation
- National Institute of Mental Health (MH-41256)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- glucocorticoids, corticosterone, hippocampal long-term potentiation, dentate gyrus granule cells, excitatory postsynaptic potentials, population spike, post-tetanic potentiation, neuronal excitability, stress, CA1 field
- MeSH terms
- Animals, Corticosterone, Electric Stimulation, Electrophysiology, Hippocampus, Male, Reaction Time, Rats, Sprague-Dawley, Rats
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