Cited by 323Neuroscience and Neuropharmacology ResearchStress Responses and CortisolMemory and Neural Mechanisms

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Effects of glucocorticoids on hippocampal long‐term potentiation

Pavlides, Constantine, Watanabe, Yoshifumi, McEwen, Bruce S.·1993·Hippocampus

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Abstract

The effects of chronic and acute corticosterone (CORT) administration were investigated on hippocampal long‐term potentiation (LTP) in the dentate gyrus granule cell layer of the rat. Electrophysiological experiments were performed in vivo under urethane anesthesia. Chronic CORT treatment (40 mg/kg/day) over 21 days decreased LTP compared to vehicle controls, even when LTP was measured 48 hours after cessation of CORT treatment, when serum CORT levels had returned to baseline. A single injection of CORT also decreased LTP compared to vehicle controls, but only when CORT levels were high, since at 48 hours after a single acute CORT injection LTP was not depressed. The decrements in LTP were seen both for the slope of the excitatory postsynaptic potential and for the population spike. Yet CORT had no effects on posttetanic potentiation or neuronal excitability. These findings are consistent with previous reports showing a reduction in LTP in the CAI field of animals exposed to stress or acute CORT administration.

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Authors: Pavlides, C., Watanabe, Y., & McEwen, B. S.
Affiliations: Rockefeller University (US)
Corresponding author: Pavlides, Constantine
ORCID: Pavlides, Constantine
Watanabe, Yoshifumi
McEwen, Bruce S.
Venue: Hippocampus
Publisher: Wiley
Published: 1993-04
Volume: 3
Issue: 2
Pages: 183-192
ISSN: 1050-9631 (ISSN-L)
1098-1063
DOI: 10.1002/hipo.450030210
OpenAlex: W2046273515
Cited by: 323
References: 61
Citations by year: 2026: 1 · 2025: 2 · 2024: 5 · 2023: 2 · 2022: 6 · 2021: 12 · 2020: 7 · 2019: 7 · 2018: 12 · 2017: 7 · 2016: 4 · 2015: 7 · 2014: 13 · 2013: 8 · 2012: 13
FWCI: 3.01
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4213 d)
Locations: Hippocampus (publishedVersion)
PubMed (publishedVersion)
Funders: Whitehall Foundation
National Institute of Mental Health (MH-41256)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: glucocorticoids, corticosterone, hippocampal long-term potentiation, dentate gyrus granule cells, excitatory postsynaptic potentials, population spike, post-tetanic potentiation, neuronal excitability, stress, CA1 field
MeSH terms: Animals, Corticosterone, Electric Stimulation, Electrophysiology, Hippocampus, Male, Reaction Time, Rats, Sprague-Dawley, Rats

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Effects of glucocorticoids on hippocampal long‐term potentiation

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