Cited by 227Cancer-related Molecular PathwaysCancer Genomics and DiagnosticsGenomics and Rare Diseases

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Analysis of TP53 Mutation Status in Human Cancer Cell Lines: A Reassessment

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Leroy, Bernard, Girard, Luc, Hollestelle, Antoinette, Minna, John D., Gazdar, Adi F., Soussi, Thierry·2014·Human Mutation

DOI 10.1002/humu.22556PMC PMC4451114

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Abstract

Tumor-derived cell lines play an important role in the investigation of tumor biology and genetics. Across a wide array of studies, they have been tools of choice for the discovery of important genes involved in cancer and for the analysis of the cellular pathways that are impaired by diverse oncogenic events. They are also invaluable for screening novel anticancer drugs. The TP53 protein is a major component of multiple pathways that regulate cellular response to various types of stress. Therefore, TP53 status affects the phenotype of tumor cell lines profoundly and must be carefully ascertained for any experimental project. In the present review, we use the 2014 release of the UMD TP53 database to show that TP53 status is still controversial for numerous cell lines, including some widely used lines from the NCI-60 panel. Our analysis clearly confirms that, despite numerous warnings, the misidentification of cell lines is still present as a silent and neglected issue, and that extreme care must be taken when determining the status of p53, because errors may lead to disastrous experimental interpretations. A novel compendium gathering the TP53 status of 2,500 cell lines has been made available (http://p53.fr). A stand-alone application can be used to browse the database and extract pertinent information on cell lines and associated TP53 mutations. It will be updated regularly to minimize any scientific issues associated with the use of misidentified cell lines (http://p53.fr).

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Authors: Leroy, B., Girard, L., Hollestelle, A., Minna, J. D., Gazdar, A. F., & Soussi, T.
Affiliations: Université Pierre-et-Marie-Curie (FR)
The University of Texas Southwestern Medical Center (US)
Erasmus MC Cancer Institute (NL)
Karolinska Institutet (SE)
Corresponding author: Soussi, Thierry
ORCID: Girard, Luc
Hollestelle, Antoinette
Minna, John D.
Gazdar, Adi F.
Soussi, Thierry
Venue: Human Mutation
Publisher: Wiley
Published: 2014-05-06
Volume: 35
Issue: 6
Pages: 756-765
ISSN: 1059-7794 (ISSN-L)
DOI: 10.1002/humu.22556
PMC: PMC4451114
OpenAlex: W2030503662
Cited by: 224
References: 53
Citations by year: 2026: 6 · 2025: 20 · 2024: 16 · 2023: 20 · 2022: 29 · 2021: 25 · 2020: 40 · 2019: 20 · 2018: 18 · 2017: 15 · 2016: 3 · 2015: 7 · 2014: 4
FWCI: 1.08
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 483 d)
Locations: Human Mutation (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Funders: National Cancer Institute (P50CA070907)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomics and Rare Diseases
Keywords: TP53 mutation status, cancer cell lines, cell line misidentification, p53, anticancer drug screening
MeSH terms: Humans, Mutation, Neoplasms, Software, Tumor Suppressor Protein p53, Internet, Databases, Genetic, Cell Line, Tumor

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Analysis of TP53 Mutation Status in Human Cancer Cell Lines: A Reassessment

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