Cited by 140Neurotransmitter Receptor Influence on BehaviorGenetic Associations and EpidemiologyOpioid Use Disorder Treatment

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin

Shi, Jinxiu, Hui, Lijian, Xu, Yonghai, Wang, Feng, Huang, Wei, Hu, Gengxi·2002·Human Mutation

DOI 10.1002/humu.9026

Open this paper in CoChat — free account

Abstract

Human mu-opioid receptor (OPRM1) is the major site for the analgesic action of most opioid drugs such as morphine, methadone and heroin. It was previously reported that a single nucleotide polymorphism (SNP) in exon1 (c.118A-->G) of OPRM1 might modestly alter the affinity in beta-endorphin-Mu interaction. Using denaturing high performance liquid chromatography (DHPLC) the complete coding region of the OPRM1 gene was screened for SNPs in Han-Chinese heroin addicts and normal control. Three novel SNPs were detected, one in exon3, one in intron3 and one in the 3' untranslated region. The SNP c.118A-->G reportedly altered the interaction of Mu receptor with opioid had no statistically significant correlation with heroin addition in Han Chinese. However, addicted subjects with the SNP in intron2 (IVS2 +31G-->A) tended to show much higher heroin intake dosages than those without this SNP. We also observed that individuals carrying both SNP c.118A-->G and IVS2 +31G-->A consumed relatively more drugs compared to other addicts. Thus our study further highlights the importance of studing the various regions of the mu opioid receptor gene, coding as well as non-coding, for genetic markers that may be linked to, or directly contribute to opioid drug-seeking behavior.

Integrity signals

Registry

Crossref · 10.1002/humu.9026

Cites

19 of 19 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Endogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry
Basbaum, A. I., & Fields, H. L. (1984) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.07.030184.001521 · Cited by 2,687
Drugs of abuse: anatomy, pharmacology and function of reward pathways
Koob, G. F. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90060-j · Cited by 2,070
Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
Horikawa, Y., Oda, N., Cox, N. J., Li, X., Orho‐Melander, M., Hara, M., Hinokio, Y., Lindner, T. H., Mashima, H., Schwarz, P. E. H., et al. (2000) · Nature Genetics · doi:10.1038/79876 · Cited by 1,467
A potent and selective endogenous agonist for the µ-opiate receptor
Zadina, J. E., Hackler, L., Ge, L.-J., & Kastin, A. J. (1997) · Nature · doi:10.1038/386499a0 · Cited by 1,309
Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity: Possible implications for opiate addiction
Bond, C. E., LaForge, K. S., Tian, M., Melia, D., Zhang, S., Borg, L., Gong, J., Schluger, J. H., Strong, J. A., Leal, S. M., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9608 · Cited by 1,072
Addictive Drugs and Brain Stimulation Reward
Wise, R. A. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.001535 · Cited by 792
Testing for linkage disequilibrium in genotypic data using the Expectation-Maximization algorithm
Slatkin, M., & Excoffier, L. (1996) · Heredity · doi:10.1038/hdy.1996.55 · Cited by 567
Pharmacological Mechanisms of Opioid Analgesics
Pasternak, G. W. (1993) · Clinical Neuropharmacology · doi:10.1097/00002826-199302000-00001 · Cited by 554
Sequence variability and candidate gene analysis in complex disease: association of micro opioid receptor gene variation with substance dependence
Hoehe, M. R. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.19.2895 · Cited by 288
μ opioid receptor gene variants: lack of association with alcohol dependence
Bergen, A. W., Kokoszka, J., Peterson, R. J., Long, J. C., Virkkunen, M. E., Linnoila, M., & Goldman, D. A. (1997) · Molecular Psychiatry · doi:10.1038/sj.mp.4000331 · Cited by 271

Show all 19 references

Sorted by citations

Molecular mechanisms of opioid receptor-dependent signaling and behavior
Al-Hasani, R., & Bruchas, M. R. (2011) · Anesthesiology · doi:10.1097/aln.0b013e318238bba6 · Cited by 1,067
Pharmacogenetics and Human Molecular Genetics of Opiate and Cocaine Addictions and Their Treatments
Kreek, M. J., Bart, G., Lilly, C., Laforge, K. S., & Nielsen, D. A. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.1.1 · Cited by 391
A Polymorphism of the μ‐Opioid Receptor Gene (OPRM1) and Sensitivity to the Effects of Alcohol in Humans
Ray, L. A., & Hutchison, K. E. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000148114.34000.b9 · Cited by 310
Effects of Naltrexone on Alcohol Sensitivity and Genetic Moderators of Medication Response: A Double-blind Placebo-Controlled Study
Ray, L. A., & Hutchison, K. E. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.9.1069 · Cited by 258
Genetic Predictors of the Clinical Response to Opioid Analgesics
L??tsch, J., Skarke, C., Liefhold, J., & Geißlinger, G. (2004) · Clinical Pharmacokinetics · doi:10.2165/00003088-200443140-00003 · Cited by 257
Increased Attributable Risk Related to a Functional μ-Opioid Receptor Gene Polymorphism in Association with Alcohol Dependence in Central Sweden
Bart, G. B., Kreek, M. J., Ott, J., LaForge, K. S., Proudnikov, D., Pollak, L., & Heilig, M. A. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300598 · Cited by 220
Association of an Asn40Asp (A118G) polymorphism in the μ-opioid receptor gene with substance dependence: A meta-analysis
Arias, A. J., Feinn, R., & Kranzler, H. R. (2006) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2005.11.024 · Cited by 178
How individual sensitivity to opiates can be predicted by gene analyses
Ikeda, K., Ide, S., Han, W., Hayashida, M., Uhl, G. R., & Sora, I. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.04.001 · Cited by 161
Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases
Clemente, N., Raineri, D., Cappellano, G., Boggio, E., Favero, F., Soluri, M. F., Dianzani, C., Comi, C., Dianzani, U., & Chiocchetti, A. (2016) · Journal of Immunological Research · doi:10.1155/2016/7675437 · Cited by 156
Association between two µ-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence
Zhang, H., Luο, X., Kranzler, H. R., Lappalainen, J., Yang, B., Krupitsky, E. M., Zvartau, E. E., & Gelernter, J. E. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl024 · Cited by 153
Genes Associated With Addiction: Alcoholism, Opiate, and Cocaine Addiction
Kreek, M. J., Nielsen, D. A., & LaForge, K. S. (2004) · NeuroMolecular Medicine · doi:10.1385/nmm:5:1:085 · Cited by 149
Are μ-opioid receptor polymorphisms important for clinical opioid therapy?
Lötsch, J., & Geißlinger, G. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.12.006 · Cited by 146
The genetics of the opioid system and specific drug addictions
Levran, O., Yuferov, V. P., & Kreek, M. J. (2012) · Human Genetics · doi:10.1007/s00439-012-1172-4 · Cited by 147
Analgesic Requirements After Major Abdominal Surgery are Associated with OPRM1 Gene Polymorphism Genotype and Haplotype
Hayashida, M., Nagashima, M., Satoh, Y., Katoh, R., Tagami, M., Ide, S., Kasai, S., Nishizawa, D., Ogai, Y., Hasegawa, J., et al. (2008) · Pharmacogenomics · doi:10.2217/14622416.9.11.1605 · Cited by 141
The Mu-Opioid Receptor Polymorphism A118G Predicts Cortisol Responses to Naloxone and Stress
Chong, R. Y., Oswald, L. M., Yang, X., Uhart, M., Lin, P., & Wand, G. S. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300856 · Cited by 140
OPRM1 SNP (A118G): Involvement in disease development, treatment response, and animal models
Mague, S. D., & Blendy, J. A. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2009.12.016 · Cited by 138
Polymorphisms in the osteopontin promoter affect its transcriptional activity.
Giacopelli, F., Marciano, R., Pistorio, A., Catarsi, P., Canini, S., Karsenty, G., & Ravazzolo, R. (2004) · Physiological Genomics · doi:10.1152/physiolgenomics.00138.2004 · Cited by 140
A review of opioid addiction genetics
Crist, R. C., Reiner, B. C., & Berrettini, W. H. (2018) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2018.07.014 · Cited by 131
Genetic–epigenetic interaction modulates µ-opioid receptor regulation
Oertel, B. G., Doehring, A., Roskam, B., Kettner, M., Hackmann, N., Ferreirós, N., Schmidt, P. H., & Lötsch, J. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds314 · Cited by 126
Personalized Medicine and Opioid Analgesic Prescribing for Chronic Pain: Opportunities and Challenges
Bruehl, S. P., Apkarian, A. V., Ballantyne, J. C., Berger, A. M., Borsook, D., Chen, W., Farrar, J. T., Haythornthwaite, J. A., Horn, S. D., Iadarola, M. J., et al. (2013) · Journal of Pain · doi:10.1016/j.jpain.2012.10.016 · Cited by 114
Pharmacogenetics of OPRM1
Crist, R. C., & Berrettini, W. H. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.10.018 · Cited by 115
A catalog of single nucleotide changes distinguishing modern humans from archaic hominins
Kuhlwilm, M., & Boeckx, C. (2019) · Scientific Reports · doi:10.1038/s41598-019-44877-x · Cited by 108
Consequences of the 118A>G polymorphism in the OPRM1 gene: translation from bench to bedside?
Mura, E., Govoni, S. M., Racchi, M., Carossa, Ranzani, G. N., Allegri, M., & van Schaik, A. (2013) · Journal of Pain Research · doi:10.2147/jpr.s42040 · Cited by 105
Genetic modulation of the pharmacological treatment of pain
Lötsch, J., Geißlinger, G., & Tegeder, I. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.06.010 · Cited by 106
Single‐nucleotide polymorphism (A118G) in exon 1 ofOPRM1gene causes alteration in downstream signaling by mu‐opioid receptor and may contribute to the genetic risk for addiction
Deb, I., Chakraborty, J., Gangopadhyay, P. K., Choudhury, S. R., & Das, S. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06472.x · Cited by 105
The opioid system in alcohol and drug dependence: Family‐based association study
Xuei, X., Wetherill, L. F., Bierut, L. J., Dick, D. M., Nürnberger, J. I., Foroud, T., & Edenberg, H. J. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30531 · Cited by 92
OPRM1 rs1799971 Polymorphism and Opioid Dependence: Evidence from a Meta-Analysis
Haerian, B. S., & Haerian, M. S. (2013) · Pharmacogenomics · doi:10.2217/pgs.13.57 · Cited by 90
The Role of the Asn40Asp Polymorphism of the Mu Opioid Receptor Gene (OPRM1) on Alcoholism Etiology and Treatment: A Critical Review
Ray, L. A., Barr, C. S., Blendy, J. A., Oslin, D. W., Goldman, D. A., & Anton, R. F. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01633.x · Cited by 81
The human μ-opioid receptor gene polymorphism 118A > G decreases cortical activation in response to specific nociceptive stimulation.
Lötsch, J., Stuck, B. A., & Hummel, T. R. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.6.1218 · Cited by 80
Pharmacogenetics of opioid receptors and addiction
Mayer, P. E., & Höllt, V. (2006) · Pharmacogenetics and Genomics · doi:10.1097/01.fpc.0000182781.87932.0d · Cited by 77
Association of Functional Opioid Receptor Genotypes With Alcohol Dependence in Koreans
Kim, S., Kim, C., Kang, D., Kim, Y., Byun, W., Kim, S., Park, J., Kim, M.-J., & Oslin, D. W. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000130803.62768.ab · Cited by 73
Molecular Imaging of Opioid and Dopamine Systems: Insights Into the Pharmacogenetics of Opioid Use Disorders
Burns, J. A., Kroll, D. S., Feldman, D. E., Liu, C. K., Manza, P., Wiers, C. E., Volkow, N. D., & Wang, G. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00626 · Cited by 75
Implications of genome wide association studies for addiction: Are our a priori assumptions all wrong?
Hall, F. S., Drgonová, J., Jain, S., & Uhl, G. R. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.07.006 · Cited by 76
Pharmacogenetics of Naltrexone in Asian Americans: A Randomized Placebo-Controlled Laboratory Study
Ray, L. A., Bujarski, S., Chin, P. F., & Miotto, K. A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.192 · Cited by 71
Endogenous Opioid Receptor Genes and Alcohol Dependence Among Taiwanese Han
Loh, E. W., Fann, C. S. J., Chang, Y. T., Chang, C. J., & Cheng, A. T.-A. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000106303.41755.b8 · Cited by 67
Nicotine alters male reproductive hormones in male albino rats: The role of cessation
Oyeyipo, I., Raji, Y., & Bolarinwa, A. (2013) · Journal of Human Reproductive Sciences · doi:10.4103/0974-1208.112380 · Cited by 67
Effect of μ-Opioid Receptor Gene Polymorphisms on Heroin-Induced Subjective Responses in a Chinese Population
Zhang, D., Shao, C., Shao, M., Yan, P., Wang, Y., Liu, Y., Liu, W., Lin, T., Xie, Y., Zhao, Y., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.012 · Cited by 63
Pharmacological Consequence of the A118G μ Opioid Receptor Polymorphism on Morphine- and Fentanyl-mediated Modulation of Ca2+Channels in Humanized Mouse Sensory Neurons
Mahmoud, S., Thorsell, A., Sommer, W. H., Heilig, M. A., Holgate, J. K., Bartlett, S. E., & Ruiz-Velasco, V. (2011) · Anesthesiology · doi:10.1097/aln.0b013e318231fc11 · Cited by 62
Association between human μ‐opioid receptor gene polymorphism, pain tolerance, and opioid addiction
Compton, P. A., Geschwind, D. H., & Alarcón, M. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20057 · Cited by 62
Pharmacogenomics of the Human µ-Opioid Receptor
Kasai, S., & Ikeda, K. (2011) · Pharmacogenomics · doi:10.2217/pgs.11.68 · Cited by 61
Gene Polymorphisms of the Mu Opioid Receptor in Methamphetamine Abusers
Ide, S., Kobayashi, H., Tanaka, K., Ujike, H., Sekine, Y., Ozaki, N., Inada, T., Harano, M., Komiyama, T., Yamada, M., et al. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1316.039 · Cited by 60
Evaluation of OPRM1 variants in heroin dependence by family-based association testing and meta-analysis
Glatt, S. J., Bousman, C., Wang, R. S., Murthy, K. K., Rana, B. K., Lasky-Su, J. A., Zhu, S. C., Zhang, R., Li, J., Zhang, B., et al. (2007) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2007.02.022 · Cited by 58
A Heroin Addiction Severity-Associated Intronic Single Nucleotide Polymorphism Modulates Alternative Pre-mRNA Splicing of the Opioid Receptor Gene OPRM1 via hnRNPH Interactions
Xu, J., Lu, Z., Xu, M., Pan, L., Deng, Y., Xie, X., Liu, H., Ding, S., Hurd, Y. L., Pasternak, G. W., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3986-13.2014 · Cited by 55
Association between human opioid receptor genes polymorphisms and pressure pain sensitivity in females*
Huang, C., Liu, H., Su, N. ‐., Hsu, Y. ‐., Yang, C. ‐., Chen, C. ‐., & Tsai, P. (2008) · Anaesthesia · doi:10.1111/j.1365-2044.2008.05760.x · Cited by 55
Genetic polymorphisms in the opioid receptor mu1 gene are associated with changes in libido and insomnia in methadone maintenance patients
Wang, S., Tsou, H., Chen, C., Chen, Y.-T., Ho, I.-K., Hsiao, C., Chou, S., Lin, K., Fang, K.-C., Huang, C.-L., et al. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.02.002 · Cited by 54
Observational study of the effect of μ-opioid receptor genetic polymorphism on intrathecal opioid labor analgesia and post-cesarean delivery analgesia
Wong, C. A., McCarthy, R. J., Blouin, J. L., & Landau, R. (2010) · International Journal of Obstetric Anesthesia · doi:10.1016/j.ijoa.2009.09.005 · Cited by 54
Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians
Ehlers, C. L., Lind, P. A., & Wilhelmsen, K. C. (2008) · BMC Medical Genetics · doi:10.1186/1471-2350-9-35 · Cited by 53
A decade of high-resolution liquid chromatography of nucleic acids on styrene–divinylbenzene copolymers
Oefner, P. J., & Huber, C. G. (2002) · Journal of Chromatography B · doi:10.1016/s1570-0232(02)00700-6 · Cited by 53
Modulation of Ca2+ Channels by Heterologously Expressed Wild-Type and Mutant Human μ-Opioid Receptors (hMORs) Containing the A118G Single-Nucleotide Polymorphism
Margas, W., Zubkoff, I., Schuler, H. G., Janicki, P. K., & Ruiz-Velasco, V. (2006) · Journal of Neurophysiology · doi:10.1152/jn.01007.2006 · Cited by 52
OPRM1 A118G Polymorphisms and Its Role in Opioid Addiction: Implication on Severity and Treatment Approaches
Taqi, M. M., Faisal, M., & Zaman, H. (2019) · Pharmacogenomics and Personalized Medicine · doi:10.2147/pgpm.s198654 · Cited by 55
An overview of the genetics of substance use disorders
Lachman, H. M. (2006) · Current Psychiatry Reports · doi:10.1007/s11920-006-0013-3 · Cited by 47
Combined analysis of circulating β-endorphin with gene polymorphisms in OPRM1, CACNAD2 and ABCB1 reveals correlation with pain, opioid sensitivity and opioid-related side effects
Rhodin, A., Grönbladh, A., Ginya, H., Nilsson, K. W., Rosenblad, A., Zhou, Q., Enlund, M., Hallberg, M., Gordh, T., & Nyberg, F. (2013) · Molecular Brain · doi:10.1186/1756-6606-6-8 · Cited by 47
ELK1 Transcription Factor Linked to Dysregulated Striatal Mu Opioid Receptor Signaling Network and OPRM1 Polymorphism in Human Heroin Abusers
Daws, S. E., Whittard, J. D., Jacobs, M. M., Ren, Y., Mazloom, A. R., Caputi, F. F., Horváth, M., Keller, É., Ma’ayan, A., Pan, Y., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.04.012 · Cited by 45
Endogenous opiates and behavior: 2002
Bodnar, R. J., & Hadjimarkou, M. M. (2003) · Peptides · doi:10.1016/j.peptides.2003.08.002 · Cited by 59
Linkage disequilibrium and association with methamphetamine dependence/psychosis of μ-opioid receptor gene polymorphisms
Ide, S., Kobayashi, H., Ujike, H., Ozaki, N., Sekine, Y., Inada, T., Harano, M., Komiyama, T., Yamada, M., Iyo, M., et al. (2006) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500355 · Cited by 43
The genetic predisposition to adverse outcome after trauma.
Giannoudis, P., van Griensven, M., Tsiridis, E., & Pape, H.-C. (2007) · Journal of Bone and Joint Surgery-british Volume · doi:10.1302/0301-620x.89b10.19022 · Cited by 38
Functionalmuopioid receptor polymorphism (OPRM1 A118G) associated with heroin use outcomes in Caucasian males: A pilot study
Woodcock, E. A., Lundahl, L. H., Burmeister, M., & Greenwald, M. K. (2015) · American Journal on Addictions · doi:10.1111/ajad.12187 · Cited by 38
Genome-Wide Association of Heroin Dependence in Han Chinese
Kalsi, G., Euesden, J., Coleman, J. R. I., Ducci, F., Alıev, F., Newhouse, S., Liu, X., Ma, X., Wang, Y., Collier, D. A., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167388 · Cited by 35
Osteopontin Alleles Are Associated with Clinical Characteristics in Systemic Lupus Erythematosus
Trivedi, T. K., Franek, B., Green, S. L., Kariuki, S. N., Kumabe, M., Mikolaitis, R., Jolly, M., Utset, T., & Niewold, T. (2011) · Journal of Biomedicine and Biotechnology · doi:10.1155/2011/802581 · Cited by 37
Enhanced prolactin levels in opium smokers
Moshtaghi‐Kashanian, G., Esmaeeli, F., & Dabiri, S. (2005) · Addiction Biology · doi:10.1080/13556210500351263 · Cited by 34
OPRM1 genetic polymorphisms are associated with the plasma nicotine metabolite cotinine concentration in methadone maintenance patients: a cross sectional study
Chen, Y.-T., Tsou, H., Kuo, H., Fang, C., Wang, S., Ho, I.-K., Chang, Y.-S., Chen, C., Hsiao, C., Wu, H.-Y., et al. (2012) · Journal of Human Genetics · doi:10.1038/jhg.2012.139 · Cited by 33
Neuropharmacological and Neurogenetic Correlates of Opioid Use Disorder (OUD) As a Function of Ethnicity: Relevance to Precision Addiction Medicine
Abijo, T., Blum, K., & Gondré‐Lewis, M. C. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666191118125702 · Cited by 33
Characterization of the 3′ untranslated region of the human mu-opioid receptor (MOR-1) mRNA
Ide, S., Han, W., Kasai, S., Hata, H., Sora, I., & Ikeda, K. (2005) · Gene · doi:10.1016/j.gene.2005.05.040 · Cited by 33
Candidate gene polymorphisms predicting individual sensitivity to opioids
Kasai, S., Hayashida, M., Sora, I., & Ikeda, K. (2007) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-007-0205-3 · Cited by 33
No evidence of association between 118A>G OPRM1 polymorphism and heroin dependence in a large Bulgarian case–control sample
Nikolov, M. A., Beltcheva, O., Galabova, A., Ljubenova, A., Jankova, E., Gergov, G., Russev, A. A., Lynskey, M. T., Nelson, E. C., Nesheva, E., et al. (2011) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.12.026 · Cited by 33
Gfi-1 takes center stage in hematopoietic stem cells
Duan, Z., & Horwitz, M. S. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.12.003 · Cited by 32
Lack of association between the A118G polymorphism of the mu opioid receptor gene (OPRM1) and opioid dependence: A meta-analysis
Somogyi, A. A. (2009) · Pharmacogenomics and Personalized Medicine · doi:10.2147/pgpm.s4865 · Cited by 25
Comprehensive Mu-Opioid-Receptor Genotyping by Pyrosequencing
Skarke, C., Kirchhof, A., Geißlinger, G., & Lötsch, J. (2004) · Clinical Chemistry · doi:10.1373/clinchem.2003.027607 · Cited by 25
Genetic variability of pain perception and treatment—clinical pharmacological implications
Lötsch, J. (2011) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-011-1012-9 · Cited by 24
Pharmacogenomics of Pain Management: The Impact of Specific Biological Polymorphisms on Drugs and Metabolism
Cornett, E. M., Turpin, M. A. C., Pinner, A., Thakur, P., Gnanasekaran, T. S., Siddaiah, H. B., Rivas, J. L. M., Yates, A., Huang, G. J., Senthil, A., et al. (2020) · Current Oncology Reports · doi:10.1007/s11912-020-0865-4 · Cited by 24
Genetic variation in heroin‐induced changes in behaviour: effects of B6 strain dose on conditioned reward and locomotor sensitization in 129‐B6 hybrid mice
Szumlinski, K. K., Lominac, K. D., Frys, K. A., & Middaugh, L. D. (2004) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2004.00111.x · Cited by 24
The Contribution of Differential Opioid Responsiveness to Identification of Opioid Risk in Chronic Pain Patients
Bruehl, S. P., Burns, J. W., Passik, S. D., Gupta, R. K., Buvanendran, A., Chont, M., Schuster, E., Orlowska, D., & France, C. R. (2015) · Journal of Pain · doi:10.1016/j.jpain.2015.04.001 · Cited by 24
Cellular signalling of non‐synonymous single‐nucleotide polymorphisms of the human μ‐opioid receptor ( OPRM 1)
Knapman, A., & Connor, M. A. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12644 · Cited by 22
Molecular and cellular basis of mu-opioid receptor signaling: mechanisms underlying tolerance and dependence development
Swingler, M., Donadoni, M., Unterwald, E. M., Maggirwar, S. B., & Sariyer, I. K. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1597922 · Cited by 24
Two novel candidate genes identified in adults from the Newfoundland population with addictive tendencies towards food
Pedram, P., Zhai, G., Gulliver, W. P., Zhang, H., & Sun, G. (2017) · Appetite · doi:10.1016/j.appet.2017.01.004 · Cited by 25
Frequency of the Dopamine Receptor D3 (rs6280) vs. Opioid Receptor µ1 (rs1799971) Polymorphic Risk Alleles in Patients with Opioid Use Disorder: A Preponderance of Dopaminergic Mechanisms?
Gondré‐Lewis, M. C., Elman, I., Alim, T. N., Chapman, E., Settles-Reaves, B., Galvao, C., Gold, M. S., Baron, D. A., Kazmi, S., Gardner, E. L., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10040870 · Cited by 21
Neurochemical Markers in the Mammalian Brain: Structure, Roles in Synaptic Communication, and Pharmacological Relevance
Rees, C. L., White, C. M., & Ascoli, G. A. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666170414163506 · Cited by 20
Is there genetic polymorphism evidence for individual human sensitivity to opiates?
Nagashima, M., Katoh, R., Satô, Y., Tagami, M., Kasai, S., & Ikeda, K. (2007) · Current Pain and Headache Reports · doi:10.1007/s11916-007-0008-8 · Cited by 20
Genetic disposition to addictive disorders — current knowledge and future perspectives
Mayer, P. E., & Höllt, V. (2004) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2004.08.009 · Cited by 20
Convergent Balancing Selection on the Mu-Opioid Receptor in Primates
Sweeney, C. G., Rando, J. M., Panas, H. N., Miller, G. M., Platt, D. M., & Vallender, E. J. (2017) · Molecular Biology and Evolution · doi:10.1093/molbev/msx105 · Cited by 16
The genetics of pain: implications for evaluation and treatment of spinal disease
Kim, D. H., & Schwartz, C. E. (2010) · The Spine Journal · doi:10.1016/j.spinee.2010.05.013 · Cited by 15
Labour analgesia; Molecular pathway and the role of nanocarriers: a systematic review
Kafshdooz, L., Kahroba, H., Kafshdooz, T., Sheervalilou, R., & Pourfathi, H. (2019) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2019.1573736 · Cited by 14
Roles of Osteopontin Gene Polymorphism (rs1126616), Osteopontin Levels in Urine and Serum, and the Risk of Urolithiasis: A Meta-Analysis
Li, X., Liu, K., Pan, Y., Zhang, J., Lv, Q., Hua, L., Wang, Z., Li, J., & Yin, C. (2015) · BioMed Research International · doi:10.1155/2015/315043 · Cited by 13
Perspectives on Current Directions in the Neurobiology of Addiction Disorders Relevant to Genetic Risk Factors
Hurd, Y. L. (2006) · CNS Spectrums · doi:10.1017/s1092852900015005 · Cited by 13
OPRD1 gene affects disease vulnerability and environmental stress in patients with heroin dependence in Han Chinese
Huang, C., Kuo, S.-C., Yeh, T., Yeh, Y., Chen, C., Liang, C., Tsou, C., Lin, C., Ho, P., & Huang, S. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.08.028 · Cited by 12
Regulation and Functional Implications of Opioid Receptor Splicing in Opioid Pharmacology and HIV Pathogenesis
Regan, P. M., Langford, D., & Khalili, K. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25237 · Cited by 13
Association between Single Nucleotide Polymorphisms in the OPRM1 Gene and Intraoperative Remifentanil Consumption in Northern Chinese Women
Liu, J., Hu, D., Jiang, Y., Xi, H., & Li, W. (2014) · Pharmacology · doi:10.1159/000368082 · Cited by 11
Murine model of OPRM1 A118G alters oxycodone self-administration and locomotor activation, but not conditioned place preference
Collins, D., Zhang, Y., Blendy, J. A., & Kreek, M. J. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107864 · Cited by 11
A Complex Relationship Among the Circadian Rhythm, Reward Circuit and Substance Use Disorder (SUD)
Samanta, S., Bagchi, D., Gold, M. S., Badgaiyan, R. D., Barh, D., & Blum, K. (2024) · Psychology Research and Behavior Management · doi:10.2147/prbm.s473310 · Cited by 9
Relapse risk revealed by degree centrality and cluster analysis in heroin addicts undergoing methadone maintenance treatment
Wang, L., Hu, F., Li, W., Li, Q., Li, Y., Zhu, J., Wei, X., Yang, J., Guo, J., Qin, Y., et al. (2021) · Psychological Medicine · doi:10.1017/s0033291721003937 · Cited by 8
Oprm1 A112G, a single nucleotide polymorphism, alters expression of stress-responsive genes in multiple brain regions in male and female mice
Collins, D., Randesi, M., da Rosa, J. C., Zhang, Y., & Kreek, M. J. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4965-x · Cited by 8
Binge-Like Eating Is Not Influenced by the Murine Model of OPRM1 A118G Polymorphism
Sachdeo, B. L. Y., Yu, L., Giunta, G. M., & Bello, N. T. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.00246 · Cited by 8
The Streetlight Effect: Reappraising the Study of Addiction in Light of the Findings of Genome-wide Association Studies
Hall, F. S., Chen, Y., & Resendiz-Gutierrez, F. (2020) · Brain Behavior and Evolution · doi:10.1159/000516169 · Cited by 7
Introducing a new recruitment approach to sample collection for genetic association studies in opioid dependence
Franke, P. E., Wendel, B., Knapp, M., Schwab, S. G., Neef, D., Maier, W., Wildenauer, D. B., & Hoehe, M. R. (2003) · European Psychiatry · doi:10.1016/s0924-9338(02)00005-6 · Cited by 6
Genetic Associations of Persistent Opioid Use After Surgery Point to OPRM1 but Not Other Opioid‐Related Loci as the Main Driver of Opioid Use Disorder
Annis, A. C., Gunaseelan, V., Smith, A. V., Abecasis, G. R., Larach, D. B., Zawistowski, M., Frangakis, S. G., & Brummett, C. M. (2024) · Genetic Epidemiology · doi:10.1002/gepi.22588 · Cited by 6
Haplotype-Based Association and In Silico Studies of OPRM1 Gene Variants with Susceptibility to Opioid Dependence Among Addicted Iranians Undergoing Methadone Treatment
Tolami, H. F., Sharafshah, A., Tolami, L. F., & Keshavarz, P. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-019-01443-4 · Cited by 5
Endogenous Opiates, Addiction, and the Stress Response
Chong, R. Y., Uhart, M., & Wand, G. S. (2007) · Elsevier eBooks · doi:10.1016/b978-012370632-4/50007-3 · Cited by 5
Enfermedad renal crónica asociada a diacetilmorfina (heroína)
Arias, J. K. B. (2008) · IATREIA · doi:10.17533/udea.iatreia.4533 · Cited by 4
Satisfaction With Methadone and Opioid Receptor Genes Polymorphisms in Treatment-Refractory Heroin-Dependent Patients
Cobos, J. P. D. L., Alcaraz, S., Siñol, N., Arranz, M. J., Trujols, J., Batlle, F., Calafell, F., Duran‐Sindreu, S., & Salazar, J. (2017) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000698 · Cited by 4
Invited Expert Opinion- Bio-informatic and Limitation Di-rectives to Help Adopt Ge-netic Addiction Risk Screening and Identify Preaddictive Reward Dysregulation: Re-quired Analytic Evidence to Induce Dopamine Homeo-statsis
Blum, K., Gold, M. S., Cadet, J. L., Lewis, M., McLaughlin, T., Braverman, E. R., Elman, I., Carney, B., Cortese, R., Abijo, T., et al. (2023) · Medical Research Archives · doi:10.18103/mra.v11i8.4211 · Cited by 6

Authors: Shi, J., Hui, L., Xu, Y., Wang, F., Huang, W., & Hu, G.
Affiliations: Chinese Academy of Sciences (CN)
Chinese National Human Genome Center at Shanghai (CN)
ORCID: Shi, Jinxiu
Hui, Lijian
Huang, Wei
Venue: Human Mutation
Publisher: Hindawi Limited
Published: 2002-03-18
Volume: 19
Issue: 4
Pages: 459-460
ISSN: 1059-7794 (ISSN-L)
1098-1004
DOI: 10.1002/humu.9026
OpenAlex: W2017514322
Cited by: 140
References: 19
Citations by year: 2025: 2 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 8 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 6 · 2014: 6 · 2013: 10 · 2012: 8
FWCI: 2.91
Type: journal article
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 4915 d)
Locations: Human Mutation (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Keywords: mu-opioid receptor, OPRM1, heroin addiction, opioid use disorder, single nucleotide polymorphisms, genetic susceptibility, Han Chinese, 3' untranslated region, drug-seeking behavior
MeSH terms: China, Chromatography, High Pressure Liquid, Exons, Gene Frequency, Genetic Testing, Genotype, Heroin Dependence, Humans, Introns, Phenotype, Genetic Variation, Receptors, Opioid, mu, Genetic Predisposition to Disease, 3' Untranslated Regions, Asian People

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks