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Is there a gender difference in the prevalence of Crohnʼs disease or ulcerative colitis?
Abstract
Gender distribution in inflammatory bowel disease (IBD) is dependent on the disease subtype, Crohn's disease (CD) or ulcerative colitis (UC). In CD there is a greater prevalence of females, while in UC population-based studies have shown no significant differences.1 However, the gender ratios in CD are highly dependent on the age as well as geographic region. Three large studies of CD incidence in North America from the 1990s (Kaiser Permanente Health Maintenance Organization [HMO] in Northern California, and population-based studies in Olmsted County, Minnesota and the Province of Manitoba) consistently demonstrated greater female incidences than males, ranging from a ratio 1.2 to 1.4.1,–3 Similar gender ratios were also observed in population-based Scandinavian studies with a ratios that ranged from 1.1 (Stockholm County, Sweden) to 1.4 (Copenhagen, Denmark).4,–6 More recent data from a study in Northern France reported a female-to-male ratio of 1.2.7 Studies of hospitalized incident cases of CD showed similar patterns.
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Environmental exposures may be contributing to the pathogenesis of IBD.
“Therefore, the latter suggests that environmental exposures may be contributing to the pathogenesis of IBD [24].”
From Intestinal Microbiota Is Influenced by Gender and Body Mass Index (2016) · cites this paper as [24]
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Metadata
- Authors
- Brant, S. R., & Nguyen, G. C.
- Affiliations
- Johns Hopkins University (US)
- Mount Sinai Hospital (CA)
- Venue
- Inflammatory Bowel Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-10
- Volume
- 14
- Issue
- Supplement
- Pages
- S2-S3
- ISSN
- 1078-0998 (ISSN-L)
- OpenAlex
- W2171021533
- Cited by
- 60
- References
- 19
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 3 · 2023: 1 · 2022: 9 · 2021: 3 · 2020: 5 · 2019: 4 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 7 · 2012: 5
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Inflammatory Bowel Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
- Keywords
- Crohn's disease, ulcerative colitis
- MeSH terms
- Age Factors, Colitis, Ulcerative, Crohn Disease, Demography, Female, Humans, Male, Risk Factors, Sex Factors, Prevalence
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