Crohn's disease in Olmsted County, Minnesota, 1940–1993: Incidence, prevalence, and survival
Open accessAbstract
Background & aims Many centers worldwide have reported an increased incidence of Crohn's disease, but population-based data in North America are sparse. We studied the incidence and prevalence of Crohn's disease in Olmsted County, Minnesota, and examined temporal trends in incidence and survival.Methods Residents diagnosed with Crohn's disease between 1970 and 1993 were incidence cases, and residents with Crohn's disease who were alive on January 1, 1991, were prevalence cases. Cases from previous studies were reconfirmed. Rates were adjusted using 1990 U.S. Census figures for whites. Incidence trends were evaluated with a Poisson regression model. Survival from diagnosis was compared with that expected for U.S. north-central whites.Results Between 1940 and 1993, 225 incidence cases were identified, for an adjusted incidence rate of 5.8 per 100,000 person-years. On January 1, 1991, there were 145 residents with Crohn's disease, an adjusted prevalence rate of 133 per 100,000, 46% higher than that seen in 1980. Incidence rates before 1964 were significantly lower than those of 1989-1993. Observed survival was less than expected (P = 0.007).Conclusions The incidence of Crohn's disease has stabilized since the 1970s at a rate higher than that seen previously. Prevalence has increased by 46% since 1980. Overall survival is slightly decreased.
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In Olmsted County, the IBD Prevalence Doubling Period was about 25 years, rising from 145 per 100,000 in 1965 to 362 per 100,000 in 1991.
“for example, in Olmsted County, MN, USA, the Prevalence Doubling Period was approximately 25 years from 145 per 100,000 in 1965 to 362 per 100,000 in 1991 (refs32,67,68).”
From The four epidemiological stages in the global evolution of inflammatory bowel disease (2021) · cites this paper as [68]
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- Authors
- Loftus, E. V., Silverstein, M. D., Sandborn, W. J., Tremaine, W. J., Harmsen, W. S., & Zinsmeister, A. R.
- Affiliations
- Mayo Clinic (US)
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1998-06
- Volume
- 114
- Issue
- 6
- Pages
- 1161-1168
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2171373302
- Cited by
- 623
- References
- 35
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 5 · 2023: 12 · 2022: 13 · 2021: 21 · 2020: 16 · 2019: 17 · 2018: 16 · 2017: 30 · 2016: 26 · 2015: 21 · 2014: 21 · 2013: 33 · 2012: 31
- FWCI
- 9.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Mayo Foundation for Medical Education and Research
- American Gastroenterological Association
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR030582, AR30582)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Keywords
- Crohn's disease, incidence, prevalence, survival, temporal trends, Olmsted County, Minnesota, population-based epidemiology, incidence rates
- MeSH terms
- Adolescent, Adult, Aged, Child, Child, Preschool, Crohn Disease, Female, Humans, Male, Middle Aged, Minnesota, Regression Analysis, Cohort Studies, Incidence, Prevalence, Proportional Hazards Models, Survival Analysis, Age Distribution, Sex Distribution
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