Serum anti-glycan antibodies predict complicated Crohnʼs disease behavior: A cohort study†
Abstract
BACKGROUND: A high proportion of patients with Crohn's disease (CD) over time develop complications like fistulae and strictures, requiring surgery. We tested a panel of antiglycan antibodies for predicting the occurrence of complications and CD-related surgery in an adult patient cohort. METHODS: Serum samples of 149 CD patients of the German inflammatory bowel disease (IBD) network were tested for the presence of anti-laminarin IgA (Anti-L), anti-chitin IgA (Anti-C), anti-chitobioside IgA (ACCA), anti-laminaribioside IgG (ALCA), anti-mannobioside IgG (AMCA), and anti-Saccaromyces cerevisiae IgG (gASCA) carbohydrate antibodies by enzyme-linked immunosorbent assay (ELISA) (IBDX(R) panel, Glycominds, Lod, Israel) in a blinded fashion. Clinical data were available on occurrence of complicated disease or CD-related surgery as well as disease activity, onset, and location. RESULTS: The median follow-up of the patients without any previous complication or surgery at time of sample procurement was 53.7 months. Overall, 26.3% developed a complication and 17.1% underwent CD-related surgery, respectively. Positivity for gASCA, AMCA, ACCA, and Anti-L alone or an increasing frequency of positive serum antibodies independently predicted a faster progression toward a more severe disease course. Once a complication or surgery had occurred only positivity for Anti-L or more than 3 markers out of the whole panel indicated progression to an additional surgery or complication. The antibody status of most patients remained stable over time. CONCLUSIONS: This is the first study showing the clinical value of serum antiglycan antibodies for prediction of a more complicated disease course in adult patients with CD.
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- Authors
- Rieder, F., Schleder, S., Wolf, A., Dirmeier, A., Strauch, U., Obermeier, F., Lopez, R., Spector, L., Fire, E., Yarden, J., Rogler, G., Dotan, N., & Klebl, F.
- Affiliations
- University of Regensburg (DE)
- University of Zurich (CH)
- Venue
- Inflammatory Bowel Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-08
- Volume
- 16
- Issue
- 8
- Pages
- 1367-1375
- ISSN
- 1078-0998 (ISSN-L)
- OpenAlex
- W1983901390
- Cited by
- 84
- References
- 25
- Citations by year
- 2023: 3 · 2022: 2 · 2021: 7 · 2020: 5 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 9 · 2015: 6 · 2014: 8 · 2013: 14 · 2012: 8
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Inflammatory Bowel Diseases (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Health Sciences › Medicine › Epidemiology › Autoimmune and Inflammatory Disorders
- Keywords
- Crohn's disease
- MeSH terms
- Adult, Antibodies, Chitin, Crohn Disease, Female, Follow-Up Studies, Glucans, Humans, Male, Polysaccharides, Predictive Value of Tests, Prospective Studies, Cohort Studies, Disease Progression
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