The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Magnetic resonance imaging for evaluation of Crohnʼs disease: Validation of parameters of severity and quantitative index of activity
Abstract
BACKGROUND: The use of magnetic resonance imaging (MRI) for assessment of Crohn's disease (CD) is expanding. The aim of this study is to define and provide an external validation of the MRI predictors of active CD, severe CD, and a quantitative Magnetic Resonance Index of Activity (MaRIA). METHODS: In all, 48 patients with clinically active (n = 29) or inactive (n = 19) CD underwent ileocolonoscopy (reference standard) and MRI. T2-weighted and pre- and postcontrast-enhanced T1-weighted sequences were acquired. Endoscopic activity was evaluated by the Crohn's Disease Endoscopic Index of Severity (CDEIS), and also classified as absent, mild (inflammation without ulcers), or severe (presence of ulceration). RESULTS: In complete agreement with a previous derivation study, independent predictors of disease severity using CDEIS as a reference were wall thickness, relative contrast enhancement (RCE), presence of edema, and ulcers on MRI. Estimation of activity in each segment using this regression model, or another with simplified coefficients (MaRIA(S) = 1.5*wall thickness + 0.02*RCE + 5*edema + 10*ulceration) correlated with CDEIS (r = 0.798, P< 0.001; r = 0.80 P < 0.001, respectively). In the validation cohort both indexes had a high and equal accuracy for diagnosis of active disease: receiver operator characteristic (ROC) area 0.93, sensitivity 0.87, specificity 0.87 using a cutoff point ≥ 7, and for diagnosis of severe disease: ROC area 0.96, sensitivity 0.92, specificity 0.92 using a cutoff point ≥ 11. The total of segment values (MaRIA(T)) correlated with global CDEIS (r = 0.83, P< 0.001). CONCLUSIONS: The MRI variables that should be evaluated in clinical practice to diagnose active CD and severe CD are validated, as well as the quantitative index of activity for use in research studies.
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A note on a general definition of the coefficient of determination
NAGELKERKE, N. J. D. (1991) · Biometrika · doi:10.1093/biomet/78.3.691 · Cited by 5,927
A SIMPLE INDEX OF CROHN'S-DISEASE ACTIVITY
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External validation is necessary in prediction research:
Bleeker, S. E., Moll, H. A., Steyerberg, E. W., Donders, A. R. T., Derksen-Lubsen, G., Grobbee, D. E., & Moons, K. G. M. (2003) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(03)00207-5 · Cited by 710
Magnetic resonance for assessment of disease activity and severity in ileocolonic Crohn’s disease
Rimola, J., Rodriguez, S., García-Bosch, O., Ordás, I., Ayala, E., Aceituno, M., Pellisé, M., Ayuso, C., Ricart, E., Donoso, L., et al. (2009) · Gut · doi:10.1136/gut.2008.167957 · Cited by 675
Self-citationHorsthuis, K., Bipat, S., Bennink, R. J., & Stoker, J. (2008) · Radiology · doi:10.1148/radiol.2471070611 · Cited by 634
Siddiki, H. A., Fidler, J. L., Fletcher, J. G., Burton, S. S., Huprich, J. E., Hough, D. M., Johnson, C. D., Bruining, D. H., Loftus, E. V., Sandborn, W. J., et al. (2009) · American Journal of Roentgenology · doi:10.2214/ajr.08.2027 · Cited by 389
Evidence base of clinical diagnosis: Evaluation of diagnostic procedures
Knottnerus, J. A. (2002) · BMJ · doi:10.1136/bmj.324.7335.477 · Cited by 346
Cited by
Lamb, C. A., Kennedy, N. A., Raine, T., Hendy, P. A., Smith, P. J., Limdi, J. K., Hayee, B., Lomer, M. C. E., Parkes, G. C., Selinger, C., et al. (2019) · Gut · doi:10.1136/gutjnl-2019-318484 · Cited by 2,346
Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn’s disease
Ruemmele, F. M., Veres, G., Kolho, K. L., Griffiths, A., Levine, A., Escher, J. C., Amil Dias, J., Barabino, A., Braegger, C. P., Bronsky, J., et al. (2014) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2014.04.005 · Cited by 1,083
Panes, J., Bouhnik, Y., Reinisch, W., Stoker, J., Taylor, S. A., Baumgart, D. C., Danese, S., Halligan, S., Marincek, B., Matos, C., et al. (2013) · Journal of Crohn's and Colitis · doi:10.1016/j.crohns.2013.02.020 · Cited by 668
Self-citationBruining, D. H., Zimmermann, E. M., Loftus, E. V., Sandborn, W. J., Sauer, C. G., Strong, S. A., & Society of Abdominal Radiology Crohn’s Disease-Focused Panel (2018) · Radiology · doi:10.1148/radiol.2018171737 · Cited by 336
Rimola, J., Planell, N., Rodríguez, S., Delgado, S., Ordás, I., Ramírez-Morros, A., Ayuso, C., Aceituno, M., Ricart, E., Jauregui-Amezaga, A., et al. (2015) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.424 · Cited by 270
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Metadata
- Authors
- Rimola, J., Ordás, I., Rodriguez, S., García-Bosch, O., Aceituno, M., Llach, J., Ayuso, C., Ricart, E., & Panés, J.
- Venue
- Inflammatory Bowel Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-08
- Volume
- 17
- Issue
- 8
- Pages
- 1759-1768
- ISSN
- 1078-0998 (ISSN-L)
- OpenAlex
- W2029746055
- Cited by
- 503
- References
- 14
- FWCI
- 10.39
- Type
- journal article
- Language
- en
- Open access
- closed
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