The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Mathematical weighting of the pediatric Crohnʼs disease activity index (PCDAI) and comparison with its other short versions
Abstract
BACKGROUND: The Pediatric Crohn's Disease Activity Index (PCDAI) has become the standard outcome measure in pediatric Crohn's disease (CD) clinical research. Other versions have been proposed but without systematic evaluation. The aim was to assess validity and responsiveness of the abbreviated PCDAI (abbrPCDAI), short PCDAI (shPCDAI), and modified PCDAI (modPCDAI) as measures of disease activity and to compare these with a mathematically weighted version developed here (wPCDAI). METHODS: The raw data from four prospectively collected datasets were used, totaling 437 children with CD (including two clinical trials). Discriminant validity utilized physician global assessment of disease activity (PGA), and construct validity the correlation with PGA and laboratory results. Feasibility and face validity were ascertained by a survey of 33 experts in pediatric CD. RESULTS: The wPCDAI had better performance than the PCDAI in construct validity and responsiveness and it discriminated better between the disease activity categories (area under the receiver operator characteristic [ROC] 0.97; 95% confidence interval [CI]: 0.95-0.99). In comparison to the original PCDAI, the noninvasive versions (abbrPCDAI and shPCDAI) had lower face, construct, and discriminant validity but were judged to be significantly more feasible. The modPCDAI performed well in the construct validation but was consistently inferior in all other parameters. Cutoffs that correspond to remission, response, and gradations of disease activity were determined for each index. CONCLUSIONS: The newly weighted wPCDAI performed better than the original PCDAI and is more feasible. The noninvasive versions (shPCDAI and abbrPCDAI) are inferior to the full PCDAI, but when needed in retrospective studies either may be equally used.
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Citations
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Cited by
The Medical Management of Paediatric Crohn’s Disease: an ECCO-ESPGHAN Guideline Update
van Rheenen, P. F., Aloi, M., Assa, A., Bronsky, J., Escher, J. C., Fagerberg, U. L., Gasparetto, M., Gerasimidis, K., Griffiths, A., Henderson, P., et al. (2021) · Journal of Crohn's and Colitis · doi:10.1093/ecco-jcc/jjaa161 · Cited by 729
Self-citationThe Burden of Inflammatory Bowel Disease in Europe in 2020
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parental psychological factors and quality of life of children with inflammatory bowel disease
Bramuzzo, M., De Carlo, C., Arrigo, S., Pavanello, P. M., Canaletti, C., Giudici, F., Agrusti, A., Martelossi, S., Di Leo, G., & Barbi, E. (2020) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002548 · Cited by 28
Metadata
- Authors
- Turner, D., Griffiths, A. M., Walters, T. D., Seah, T., Markowitz, J., Pfefferkorn, M., Keljo, D., Waxman, J., Otley, A., LeLeiko, N. S., Mack, D., Hyams, J., & Levine, A.
- Venue
- Inflammatory Bowel Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-01
- Volume
- 18
- Issue
- 1
- Pages
- 55-62
- ISSN
- 1078-0998 (ISSN-L)
- OpenAlex
- W2019804961
- Cited by
- 301
- References
- 20
- FWCI
- 3.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- Turner, D., Griffiths, A. M., Walters, T. D., Seah, T., Markowitz, J., Pfefferkorn, M., Keljo, D., Waxman, J., Otley, A., LeLeiko, N. S., Mack, D., Hyams, J., & Levine, A. (2012). Mathematical weighting of the pediatric Crohnʼs disease activity index (PCDAI) and comparison with its other short versions. Inflammatory Bowel Diseases. https://doi.org/10.1002/ibd.21649
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