The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Appraisal of the pediatric ulcerative colitis activity index (PUCAI)
Abstract
BACKGROUND: We evaluated the psychometric performance of the Pediatric Ulcerative Colitis Activity Index (PUCAI) in a real-life cohort from the Pediatric IBD Collaborative Research Group. METHODS: Two consecutive visits of 215 children with ulcerative colitis (UC) were included (mean age 11.2 +/- 3.6 years; 112 (52%) males; 63 (29%) newly diagnosed and the others after disease duration of 24 +/- 15.6 months). Validity was assessed using several constructs of disease activity. Distributional and anchor-based strategies were used to assess the responsiveness of the PUCAI to change over time following treatment. RESULTS: Reflecting feasibility, 97.6% of 770 eligible registry visits had a completed PUCAI score versus only 47.6% for a contemporaneously collected Pediatric Crohn's Disease Activity Index (odds ratio = 45.8, 95% confidence interval [CI] 28.6-73.5) obtained for children with Crohn's disease accessioned into the same database. The PUCAI score was significantly higher in patients requiring escalation of medical therapy (45 points [interquartile range, IQR, 30-60]) versus those who did not, (0 points [IQR 0-10]; P < 0.001), and was highly correlated with physician's global assessment of disease activity (r = 0.9, P < 0.001). The best cutoff to differentiate remission from active disease was 10 points (area under receiver operating characteristic curve [AUC] 0.94; 95% CI 0.90-0.97). Test-retest reliability was excellent (intraclass correlation coefficient = 0.89; 95% CI 0.84-0.92, P < 0.001) as well as responsiveness to change (AUC 0.96 [0.92-0.99]; standardized response mean 2.66). CONCLUSION: This study on real-life, prospectively obtained data confirms that the PUCAI is highly feasible by virtue of the noninvasiveness, valid, and responsive index. The PUCAI can be used as a primary outcome measure to reflect disease activity in pediatric UC.
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Cites
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Silverberg, M. S., Satsangi, J., Ahmad, T., Arnott, I. D., Bernstein, C. N., Brant, S. R., Caprilli, R., Colombel, J.-F., Gasche, C., Geboes, K., et al. (2005) · Canadian Journal of Gastroenterology · doi:10.1155/2005/269076 · Cited by 3,409
Development of a Crohn's Disease Activity Index
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Cited by
Turner, D., Ricciuto, A., Lewis, A., D’Amico, F., Dhaliwal, J., Griffiths, A. M., Bettenworth, D., Sandborn, W. J., Sands, B. E., Reinisch, W., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.12.031 · Cited by 2,911
Self-citationTurner, D., Ruemmele, F. M., Orlanski‐Meyer, E., Griffiths, A. M., de Carpi, J. M., Bronsky, J., Veres, G., Aloi, M., Strisciuglio, C., Braegger, C. P., et al. (2018) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002035 · Cited by 481
Self-citationTurner, D., Levine, A., Escher, J. C., Griffiths, A. M., Russell, R. K., Dignass, A., Dias, J. A., Bronsky, J., Braegger, C. P., Cucchiara, S., et al. (2012) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3182662233 · Cited by 382
Self-citationTurner, D., Griffiths, A. M., Walters, T. D., Seah, T., Markowitz, J., Pfefferkorn, M., Keljo, D., Waxman, J., Otley, A., LeLeiko, N. S., et al. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21649 · Cited by 301
Self-citationparental psychological factors and quality of life of children with inflammatory bowel disease
Bramuzzo, M., De Carlo, C., Arrigo, S., Pavanello, P. M., Canaletti, C., Giudici, F., Agrusti, A., Martelossi, S., Di Leo, G., & Barbi, E. (2020) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002548 · Cited by 28
Metadata
- Authors
- Turner, D., Hyams, J., Markowitz, J., Lerer, T., Mack, D. R., Evans, J., Pfefferkorn, M., Rosh, J., Kay, M., Crandall, W., Keljo, D., Otley, A. R., Kugathasan, S., Carvalho, R., Oliva-Hemker, M., Langton, C., Mamula, P., Bousvaros, A., LeLeiko, N., & Griffiths, A. M.
- Venue
- Inflammatory Bowel Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-08
- Volume
- 15
- Issue
- 8
- Pages
- 1218-1223
- ISSN
- 1078-0998 (ISSN-L)
- OpenAlex
- W2144472014
- Cited by
- 313
- References
- 34
- FWCI
- 6.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Turner, D., Hyams, J., Markowitz, J., Lerer, T., Mack, D. R., Evans, J., Pfefferkorn, M., Rosh, J., Kay, M., Crandall, W., Keljo, D., Otley, A. R., Kugathasan, S., Carvalho, R., Oliva-Hemker, M., Langton, C., Mamula, P., Bousvaros, A., LeLeiko, N., & Griffiths, A. M. (2009). Appraisal of the pediatric ulcerative colitis activity index (PUCAI). Inflammatory Bowel Diseases. https://doi.org/10.1002/ibd.20867
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