The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Acceptance, availability, and feasibility of RTS, S/AS01 malaria vaccine: A review
Open accessAbstract
Introduction: In malaria‐stricken regions, malaria continues to be one of the primary causes of mortality for children. The number of malaria‐related fatalities has drastically decreased because of artemisinin‐based pharmacological regimens. Methods: Two independent researchers did a comprehensive literature search using PubMed/MEDLINE and Google Scholar from its inception to September 2022. Results: After evaluating RTS, S/AS01 for its safety, effectiveness, and feasibility, the European Medicines Agency (EMA) issued a favorable conclusion. It was suggested that the RTS, S malaria vaccine be used extensively by the World Health Organization on October 6, 2021. The successful pilot program testing the malaria vaccine in Ghana, Kenya, and Malawi served as the basis for this proposal. Conclusion: Several challenges need to be addressed to ensure the success of vaccination programs. From the acceptability perspective, issues such as inadequate community engagement, concerns about side effects, and issues with the delivery and quality of healthcare services can affect the acceptance of the vaccine. From the feasibility standpoint, factors such as lack of transportation or long distances to healthcare facilities and the perception of completion of the vaccination calendar can affect the feasibility of the vaccine. Lastly, the availability of the vaccine is also a major concern as it may not be readily available to meet the demands.
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“Currently, RTS, S/AS01 (RTS, S) is the only malaria vaccine specifically recommended for use in pregnant women.”
From Current update on malaria in pregnancy: a systematic review (2025) · cites this paper as [218]
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“There are no other vaccines available at this time for the prevention of malaria in pregnancy, apart from RTS, S, which is used in malaria-endemic regions, particularly during the second or third trimester of pregnancy [218, 219].”
From Current update on malaria in pregnancy: a systematic review (2025) · cites this paper as [218]
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Cited by
Current update on malaria in pregnancy: a systematic review
Minwuyelet, A., Yewhalaw, D., Siferih, M., & Atenafu, G. (2025) · Tropical Diseases, Travel Medicine and Vaccines · doi:10.1186/s40794-025-00248-1 · Cited by 49
Metadata
- Authors
- Mumtaz, H., Nadeem, A., Bilal, W., Ansar, F., Saleem, S., Khan, Q. A., Tango, T., Farkouh, C., Belay, N. F., Verma, R., Farkouh, M., & Saqib, M.
- Affiliations
- Health Services Academy (PK)
- Dow University of Health Sciences (PK)
- King Abdullah Teaching Hospital Mansehra Pakistan
- Mayo Hospital (PK)
- DHQ and Teaching Hospital KDA Kohat Kohat Pakistan
- Faculty of Medicine Universitas Jakarta Indonesia
- Rush University Medical Center (US)
- Michigan State University (US)
- St. George's University (GD)
- Ponce Health Sciences University, St. Louis (US)
- Khyber Medical College (PK)
- Corresponding author
- Verma, Ravina
- ORCID
- Venue
- Immunity, Inflammation and Disease
- Publisher
- Wiley
- Published
- 2023-06
- Volume
- 11
- Issue
- 6
- Pages
- e899-e899
- ISSN
- 2050-4527 (ISSN-L)
- PMC
- PMC10266133
- OpenAlex
- W4380682435
- Cited by
- 42
- References
- 38
- Citations by year
- 2026: 5 · 2025: 17 · 2024: 16 · 2023: 4
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Immunity Inflammation and Disease (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Social Sciences › Health › Vaccine Coverage and Hesitancy
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Travel-related health issues
- Keywords
- RTS,S/AS01 malaria vaccine, malaria vaccine, vaccine acceptance, vaccine availability, vaccine feasibility, vaccine safety and efficacy, community participation, vaccine side effects, health care access
- MeSH terms
- Child, Feasibility Studies, Ghana, Humans, Kenya, Malaria Vaccines, Drug-Related Side Effects and Adverse Reactions
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