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Cited by 100Nutritional Studies and DietCancer Risks and FactorsGlobal Cancer Incidence and Screening

Dietary factors protective against breast cancer in Japanese premenopausal and postmenopausal women

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Hirose, Kaoru, Takezaki, Toshiro, Hamajima, Nobuyuki, Miura, Shigeto, Tajima, Kazuo·2003·International Journal of Cancer
DOI 10.1002/ijc.11373
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Abstract

Since components of the Japanese diet that might be responsible for the relatively low breast cancer incidence rates observed in Japan have not been clarified in detail, a case‐referent study with reference to menopausal status was conducted using data from the hospital‐based epidemiologic research program at Aichi Cancer Center (HERPACC). In total, 2,385 breast cancer cases were included, and 19,013 women, confirmed as free of cancer, were recruited as the reference group. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were determined by multiple logistic regression analysis. There were reductions in risk associated with high intake of milk and green–yellow vegetables (green leafy vegetables, carrots and pumpkins) among both pre‐ and postmenopausal women. The protective effects of the Japanese diet were more prominent among postmenopausal than premenopausal women. The adjusted OR of fish consumption (5 or more times per week vs. fewer than 3 times per month) was 0.75 (95% CI 0.57–0.98, ptrend = 0.01) for postmenopausal breast cancer. A significant decrease in postmenopausal breast cancer risk was also observed for increasing intake of fruit (OR = 0.61, 95% CI 0.41–0.91). Thus, traditional Japanese dietary factors may protect against breast cancer development, especially among postmenopausal women. © 2003 Wiley‐Liss, Inc.

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  • Of 44 case-control studies, 32 showed higher consumption of soy foods and/or soy isoflavones was associated with lower risk for primary breast cancer, breast cancer mortality, or improved markers of prognosis among the overall study population.

    “Overall, of the 44 case control studies, 32 showed that higher consumption of soy foods and/ or soy isoflavones was associated with lower risk for primary breast cancer [42-46,49-51,53,54,56-58,61-64,66,71-73,75,77-79,81,83], breast cancer mortality [55], or improved markers of prognosis (ER+ status vs receptor negative status) [74,82] among the overall study population.”

    From Soy, Red Clover, and Isoflavones and Breast Cancer: A Systematic Review (2013) · cites this paper as [54]

    The Results (page unavailable) report lower breast-cancer risk with higher tofu intake in premenopausal women, so this paper supports its inclusion as a case-control study finding an inverse association. The same passage says the association was not found in postmenopausal women; it therefore does not support the claim's qualification that the finding applied to the overall study population. (LLM, conf=0.87)

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Research works printed but not linked: 43

  1. Moolgavkar SH, Stevens RG, Lee JAH. Effect of age on incidence of breast cancer in females. J Natl Cancer Inst 1979;62:493-501.
  2. Stampfer MJ, Willett WC, Colditz GA, Speizer FE. Intake of choles- terol, fish and specific types of fat in relation to risk of breast cancer. In: Lands WE, ed. Proceedings of the AOCS short course on poly- unsaturated fatty acids and eicosanoids. Champaign, IL: American Oil Chemists' Society Press, 1987. 248 -52.
  3. Toniolo P, Riboli E, Shore RE, Pasternak BS. Consumption of meat, animal products, protein, and fat and risk of breast cancer: a prospec- tive cohort study in New York. Epidemiology 1994;5:391-7.
  4. Vatten LJ, Solvoll K, Loken EB. Frequency of meat and fish intake and risk of breast cancer in a prospective study of 14,500 Norwegian women. Int J Cancer 1990;46:12-5.
  5. Blot WJ, Lanier A, Fraumeni JF Jr, Bender TR. Cancer mortality among Alaskan natives, 1960 -1969. J Natl Cancer Inst 1975;55:547-54.
  6. Karmali RA, Marsh J, Fuchs C. Effect of omega-3 fatty acids on growth of a rat mammary tumor. J Natl Cancer Inst 1984;73:457-61.
  7. Reddy BS. Omega-3 fatty acids as anticancer agents. In: Nelson GJ, ed. Health effects of dietary fatty acids. Champaign, IL: American Oil Chemists' Society Press, 1990. 157-66.
  8. Cave WT. Dietary n-3 (-3) polyunsaturated fatty acid effects on animal tumorigenesis. FASEB J 1991;5:2160 -6.
  9. Adlercreutz H, Mazur W. Phyto-oestrogens and Western diseases. Ann Med 1997;29:95-120.
  10. Murrill WB, Brown NM, Zhang JX, Manzolillo PA, Barnes S, Lamar- tiniere CA. Prepubertal genistein exposure suppresses mammary can- cer and enhances gland differentiation in rats. Carcinogenesis 1996; 17:1451-7.
  11. Messina M, Barnes S, Setchell KD. Phyto-oestrogens and breast cancer. Lancet 1997;350:971-2.
  12. Wu AH, Ziegler RG, Horn-Ross PL, Nomura AM, West DW, Kolonel LN, Rosenthal JF, Hoover RN, Pike MC. Tofu and risk of breast cancer in Asian-Americans. Cancer Epidemiol Biomarkers Prev 1996; 5:901-6.
  13. Lee HP, Gourley L, Duffy SW, Esteve J, Lee J, Day NE. Dietary effects on breast-cancer risk in Singapore. Lancet 1991;337:1197- 200.
  14. Adlercreutz H. Phytoestrogens: epidemiology and a possible role in cancer protection. Environ Health Perspect 1995;103:103-12.
  15. Peterson G, Barnes S. Genistein inhibits both estrogen and growth factor-stimulated proliferation of human breast cancer cells. Cell Growth Differ 1996;7:1345-51.
  16. Yoo K-Y, Tajima K, Kuroishi T, Hirose K, Yoshida M, Miura S, Murai S. Independent protective effect of lactation against breast cancer: a case-control study in Japan. Am J Epidemiol 1992;135:726 - 33.
  17. Hirose K, Tajima K, Hamajima N, Inoue M, Takezaki T, Kuroishi K, Yoshida M, Tokudome S. A large-scale, hospital-based case-control study of risk factors of breast cancer according to menopausal status. Jpn J Cancer Res 1995;86:146 -54.
  18. Hirose K, Tajima K, Hamajima N, Takezaki T, Inoue M, Kuroishi T, Miura S, Tokudome S. Effect of body size on breast-cancer risk among Japanese women. Int J Cancer 1999;80:349 -55.
  19. Hirose K, Tajima K, Hamajima N, Takezaki T, Inoue M, Kuroishi T, Miura S, Tokudome S. Association of family history and other risk factors with breast cancer risk among Japanese premenopausal and postmenopausal women. Cancer Causes Control 2001;12:349 -58.
  20. Hamajima N, Hirose K, Inoue M, Takezaki T, Kuroishi T, Tajima K. Case-control studies: matched controls or all available controls? J Clin Epidemiol 1994;47:971-5.
  21. Willett WC, Browne ML, Bain C, Lipnick RJ, Stampfer MJ, Rosner B, Colditz GA, Hennekens CH, Speizer FE. Relative weight and risk of breast cancer among pre-menopausal women. Am J Epidemiol 1985;122:731-40.
  22. Le Marchand L, Kolonel LN, Earle ME, Mi P-M. Body size at different periods of life and breast-cancer risk. Am J Epidemiol 1988;128:137-52.
  23. Vatten LJ, Kvinnsland S. Body-mass index and risk of breast cancer. A prospective study of 23,826 Norwegian women. Int J Cancer 1990;45:440 -4.
  24. Tokudome S, Ikeda M, Tokudome Y, Imaeda N, Kitagawa I, Fujiwara N. Development of data-based semi-quantitative food frequency ques- tionnaire for dietary studies in middle-aged Japanese. Jpn J Clin Oncol 1998;28:679 -87.
  25. Zhang J, Temme EHM, Kesteloot H. Fish consumption in inversely associated with male lung cancer mortality in countries with high levels of cigarette smoking or animal fat consumption. Int J Epidemiol 2000;29:615-21.
  26. Tokudome Y, Imaed N, Ikeda M, Kitagawa I, Fujiwara N, Tokudome S. Foods contributing to absolute intake and variance in intake of fat, fatty acids and cholesterol in middle-aged Japanese. J Epidemiol 1999;9:78 -90.
  27. Kelsey JL, Gammon MD, John EM. Reproductive factors and breast cancer. Epidemiol Rev 1993;15:36 -47.
  28. Hunter DJ, Willett WC. Diet, body build, and breast cancer. Annu Rev Nutr 1994;14:393-418.
  29. Kaizer L, Boyd NF, Kriukov V, Tritchler D. Fish consumption and breast cancer risk: an ecological study. Nutr Cancer 1989;12 :61-8.
  30. Caygill CPJ, Hill MJ. Fish, n-3 fatty acids and human colorectal and breast cancer mortality. Eur J Cancer Prev 1995;4:329 -32.
  31. Rose DP, Connolly JM. Omega-3 fatty acids as cancer chemopreven- tive agents. Pharmacol Ther 1999;83:217-44.
  32. Galli C, Butrum R. Omega-3 fatty acids and cancer: an overview. World Rev Nutr Diet 1991;66:446 -61.
  33. Cassidy A, Bingham S, Setchell KDR. Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premeno- pausal women. Am J Clin Nutr 1994;60:333-40.
  34. Lu L-JW, Anderson KE, Grady JJ, Nagamani M. Effects of soya consumption for one month on steroid hormones in premenopausal women: implications for breast cancer risk reduction. Cancer Epide- miol Biomarkers Prev 1996;5:63-70.
  35. Nagata C, Kabuto M, Kurisu Y, Shimizu H. Decreased serum estra- diol concentration associated with high dietary intake of soy products in premenopausal Japanese women. Nutr Cancer 1997;29:228 -33.
  36. Lee HP, Gourley L, Duffy SW, Esteve J, Lee J, Day NE. Risk factors for breast cancer by age and menopausal status: a case-control study in Singapore. Cancer Causes Control 1992;3:313-22.
  37. Gandini S, Merzenich H, Robertson C, Boyle P. Meta-analysis of studies on breast cancer risk and diet: the role of fruit and vegetable consumption and the intake of associated micronutrients. Eur J Cancer 2000;36:636 -46.
  38. Smith-Warner SA, Spiegelman D, Yaun SS, Adami H-O, Beeson WL, van den Brandt PA, Folsom AR, Fraser GE, Freudenheim JL, Goldbohm RA, Graham S, Miller AB, et al. Intake of fruits and vegetables and risk of breast cancer. A pooled analysis of cohort studies. JAMA 2001;285:769-76.
  39. Le MG, Moulton LH, Hill C, Kramer A. Consumption of dairy produce and alcohol in a case-control study of breast cancer. J Natl Cancer Inst 1986;77:633-6.
  40. Jacobson EA, James KA, Newmark HL, Carroll KK. Effects of dietary fat, calcium, and vitamin D on growth and mammary tumor- igenesis induced by 7,12-dimethylbenz(a)anthracene in female Sprague-Dawley rats. Cancer Res 1989;49:6300 -3.
  41. Newmark HL. Vitamin D adequacy: a possible relationship to breast cancer. Adv Exp Med Biol 1994;364:109 -14.
  42. Hamajima N, Hirose K, Inoue M, Takezaki T, Kuroishi T, Tajima K. Age-specific risk factors of breast cancer estimated by a case-control study in Japan. J Epidemiol 1995;5:99 -105.
  43. Inoue M, Tajima K, Hirose K, Hamajima N, Takezaki T, Kurosihi T, Tominaga S. Epidemiological features of first-visit outpatients in Japan: comparison with general population and variation by sex, age, and season. J Clin Epidemiol 1997;50:69 -77.

Cited by

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Authors
Hirose, K., Takezaki, T., Hamajima, N., Miura, S., & Tajima, K.
Affiliations
  • Aichi Cancer Center Research Institute (JP)
  • Nagoya University (JP)
  • Aichi Cancer Center (JP)
Corresponding author
Hirose, Kaoru
ORCID
Venue
International Journal of Cancer
Publisher
Wiley
Published
2003-07-16
Volume
107
Issue
2
Pages
276-282
ISSN
  • 0020-7136 (ISSN-L)
  • 1097-0215
DOI
10.1002/ijc.11373
OpenAlex
W2052695128
Cited by
100
References
2
Citations by year
2025: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 8 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 6 · 2013: 5 · 2012: 4
FWCI
5.77
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • International Journal of Cancer (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
  • Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
Keywords
breast cancer, Japanese diet, dietary factors, postmenopausal women, premenopausal women, milk consumption, leafy vegetables, fish consumption, fruit consumption, cancer risk reduction
MeSH terms
Adult, Aged, Breast Neoplasms, Diet, Feeding Behavior, Female, Humans, Japan, Middle Aged, Risk Factors, Body Mass Index, Odds Ratio, Case-Control Studies, Age Distribution, Premenopause, Postmenopause

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