A high-fat diet increases the incidence of mammary cancer inc-Ha-ras proto-oncogene transgenic rats
Open accessAbstract
Mammary cancer is the most common type of cancer and the fifth most common cause of cancer-related deaths among Japanese women. The recent sharp increase in the number of women diagnosed with mammary cancer per year is thought to be associated with increased fat intake resulting from changes in the dietary habits of contemporary Japanese citizens. In this study, human c-Ha-ras proto-oncogene transgenic (Hras128) rats, which are highly susceptible to mammary carcinogens, were fed high- or low-fat diets to examine the relationship between fat consumption and the development of mammary cancer. Female 7-week-old Hras128 rats and wild-type littermates were administered benzo[a]pyrene. A week later, the animals were randomly assigned to high-fat or low-fat diet groups (45% or 10% of calories from fat, respectively). After 12 weeks, the rats were sacrificed and autopsied, and mammary tumors were excised and processed for microscopic observation. Mammary tumors were found in 11 of the 12 animals in the high-fat diet group and in 5 of the 12 animals in the low-fat diet group, and the numbers of mammary gland tumors per animal in these groups were 1.7 and 0.7, respectively. Notably, the observed differences in incidence and multiplicity of mammary tumors between the two groups were statistically significant. These results suggest a positive relationship between the incidence of breast cancer and high fat intake.
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High-fat diets have particularly been related to increased risk of colorectal, pancreatic, breast, lung, and prostate cancer.
“High-fat diets for instance have particularly been related to increased risk of colorectal (188), pancreatic (189), breast (190), lung (191), and prostate cancer (192).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [190]
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Cites
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
Ferlay, J., Shin, H.-R., Bray, F., Forman, D., Mathers, C., & Parkin, D. M. (2010) · International Journal of Cancer · doi:10.1002/ijc.25516 · Cited by 22,207 · see citing works
Nishimura, R., Osako, T., Nishiyama, Y., Tashima, R., Nakano, M., Fujisue, M., Toyozumi, Y., & Arima, N. (2013) · Oncology · doi:10.1159/000353099 · Cited by 13,239 · see citing works
Goldhirsch, A., Wood, W. C., Coates, A. S., Gelber, R. D., Thurlimann, B. J. K., & Senn, H.-J. (2011) · Annals of Oncology · doi:10.1093/annonc/mdr304 · Cited by 3,839 · see citing works
Migration Patterns and Breast Cancer Risk in Asian-American Women
Ziegler, R. G., Hoover, R. N., Pike, M. C., Hildesheim, A., Nomura, A. M. Y., West, D. W., Wu‐Williams, A. H., Kolonel, L. N., Horn‐Ross, P. L., Rosenthal, J. F., et al. (1993) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/85.22.1819 · Cited by 1,098 · see citing works
Cancers of the prostate and breast among Japanese and white immigrants in Los Angeles County
Shimizu, H., Ross, R., Bernstein, L., Yatani, R., Henderson, B. E., & Mack, T. (1991) · British Journal of Cancer · doi:10.1038/bjc.1991.210 · Cited by 890 · see citing works
Mammary Cancer Induced by a Single Feeding of Polynuclear Hydrocarbons, and its Suppression
Huggins, C., GRAND, L. C., & Brillantes, F. P. (1961) · Nature · doi:10.1038/189204a0 · Cited by 786 · see citing works
Estrogen receptors α and β in the rodent mammary gland
Saji, S., Jensen, E. V., Nilsson, S. V., Rylander‐Rudqvist, T., Warner, M. N., & Gustafsson, J.-Α. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.1.337 · Cited by 357 · see citing works
He, Y., Harris, R. E., Gao, Y., Gao, R., & Wynder, E. L. (1991) · International Journal of Epidemiology · doi:10.1093/ije/20.1.76 · Cited by 252 · see citing works
An updated report on the trends in cancer incidence and mortality in Japan, 1958–2013
Katanoda, K., Hori, M., Matsuda, T., Shibata, A., Nishino, Y., Hattori, M., Soda, M., Ioka, A., Sobue, T., & Nishimoto, H. (2015) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyv002 · Cited by 250 · see citing works
Body Mass and Mortality After Breast Cancer Diagnosis
Whiteman, M. K., Hillis, S. D., Curtis, K. M., et al. (2005) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0106 · Cited by 160 · see citing works
Dietary Fat Intake and Development of Specific Breast Cancer Subtypes
Sieri, S., Chiodini, P., Agnoli, C., Pala, V. M., Berrino, F., Trichopoulou, A., Benetou, V., Vasilopoulou, E., Sánchez, M., Chirlaque, M., et al. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dju068 · Cited by 128 · see citing works
Nutrition and physical activity influence on breast cancer incidence and outcome
Chlebowski, R. T. (2013) · The Breast · doi:10.1016/j.breast.2013.07.006 · Cited by 127 · see citing works
Dietary fat and mammary carcinogenesis
Carroll, K. K., & Braden, L. M. (1985) · Nutrition and Cancer · doi:10.1080/01635588509513831 · Cited by 121 · see citing works
Risk Factors for Breast Cancer in Elderly Women
Sweeney, C. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh276 · Cited by 101 · see citing works
Dietary factors protective against breast cancer in Japanese premenopausal and postmenopausal women
Hirose, K., Takezaki, T., Hamajima, N., Miura, S., & Tajima, K. (2003) · International Journal of Cancer · doi:10.1002/ijc.11373 · Cited by 100 · see citing works
Effect of miso (Japanese soybean paste) and NaCl on dmba‐induced rat mammary tumors
Baggott, J. E., Ha, T., Vaughn, W. H., Juliana, M. M., Hardin, J. M., & Grubbs, C. J. (1990) · Nutrition and Cancer · doi:10.1080/01635589009514083 · Cited by 55 · see citing works
Redefining the impact of nutrition on breast cancer incidence: is epigenetics involved?
Teegarden, D., Romieu, I., & Lelièvre, S. A. (2012) · Nutrition Research Reviews · doi:10.1017/s0954422411000199 · Cited by 53 · see citing works
Asamoto, M. (2000) · Carcinogenesis · doi:10.1093/carcin/21.2.243 · Cited by 52 · see citing works
Gotoh, T., Yamada, K., Ito, A., et al. (1998) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1998.tb03288.x · Cited by 50 · see citing works
Kataoka, A., Tokunaga, E., Masuda, N., et al. (2013) · Breast Cancer · doi:10.1007/s12282-013-0466-2 · Cited by 42 · see citing works
Epidemiology of breast cancer in Japan and the US.
Saika, K., & Sobue, T. (2009) · Cited by 40 · see citing works
Huggins, C., & Fukunishi, R. (1963) · Cancer Research · Cited by 27 · see citing works
Beneficial Biological Effects of Miso with Reference to Radiation Injury, Cancer and Hypertension
Watanabe, H. (2013) · Journal of Toxicologic Pathology · doi:10.1293/tox.26.91 · Cited by 27 · see citing works
Katanoda, K., Ajiki, W., Matsuda, T., et al. (2011) · Cancer Science · doi:10.1111/j.1349-7006.2011.02145.x · Cited by 26 · see citing works
Tsuda, H., Fukamachi, K., Ohshima, Y., Ueda, S., Matsuoka, Y., Hamaguchi, T., Ohnishi, T., Takasuka, N., & Naito, A. (2005) · Cancer Science · doi:10.1111/j.1349-7006.2005.00056.x · Cited by 26 · see citing works
Self-citationByrne, C., Ursin, G., & Ziegler, R. G. (1996) · Journal of Nutrition · doi:10.1093/jn/126.11.2757 · Cited by 25 · see citing works
Matsuoka, Y., Fukamachi, K., Hamaguchi, T., et al. (2003) · Toxicologic Pathology · doi:10.1080/01926230390241882 · Cited by 17 · see citing works
Ohnishi, T., Fukamachi, K., Ohshima, Y., et al. (2007) · Toxicologic Pathology · doi:10.1080/01926230701302541 · Cited by 16 · see citing works
Self-citationFemale heterozygous (+/fa) Zucker rats as a novel leptin-related mammary carcinogenesis model
Cho, Y., Imai, T., Takami, S., et al. (2012) · The Journal of Toxicological Sciences · doi:10.2131/jts.37.1025 · Cited by 2 · see citing works
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Research works printed but not linked: 2
- [21]Leary S, Underwood W, Anthony R, Cartner S, Corey D, Grandin T, and Greenacre CB AVMA Guidelines for the Euthanasia of Animals: 2013 Edition. 2013, from The American Veterinary Medical Association website: https://www.avma.org/KB/Policies/Documents/euthanasia.pdf.
- [27]American Cancer Society. Global Cancer Facts & Figures, 3rd ed. 2015, from American Cancer Society website: https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/global-cancer-facts-and-figures/global-cancer-facts-and-figures-3rd-edition.pdf.
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Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease
Smith, R. L., Soeters, M. R., Wüst, R. C. I., & Houtkooper, R. H. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00211 · Cited by 787 · see citing works
- Authors
- Magaki, M., Ishii, H., Yamasaki, A., Kitai, Y., Kametani, S., Nakai, R., Dabid, A., Tsuda, H., & Ohnishi, T.
- Affiliations
- Hyogo University (JP)
- Kagawa University (JP)
- Nagoya City University (JP)
- Corresponding author
- Ohnishi, Takamasa
- Venue
- Journal of Toxicologic Pathology
- Published
- 2017
- Volume
- 30
- Issue
- 2
- Pages
- 145-152
- ISSN
- 0914-9198 (ISSN-L)
- 1881-915X
- PMC
- PMC5406593
- OpenAlex
- W2560667519
- Cited by
- 10
- References
- 29
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 3 · 2019: 2 · 2018: 3
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Toxicologic Pathology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- breast cancer, high-fat diet, benzo[a]pyrene, dietary fat intake, breast cancer incidence, tumor multiplicity, mammary tumors, carcinogenesis
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