The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
High levels of circulating testosterone are not associated with increased prostate cancer risk: A pooled prospective study
Abstract
Androgens stimulate prostate cancer in vitro and in vivo. However, evidence from epidemiologic studies of an association between circulating levels of androgens and prostate cancer risk has been inconsistent. We investigated the association of serum levels of testosterone, the principal androgen in circulation, and sex hormone‐binding globulin (SHBG) with risk in a case‐control study nested in cohorts in Finland, Norway and Sweden of 708 men who were diagnosed with prostate cancer after blood collection and among 2,242 men who were not. In conditional logistic regression analyses, modest but significant decreases in risk were seen for increasing levels of total testosterone down to odds ratio for top vs. bottom quintile of 0.80 (95% CI = 0.59–1.06; ptrend = 0.05); for SHBG, the corresponding odds ratio was 0.76 (95% CI = 0.57–1.01; ptrend = 0.07). For free testosterone, calculated from total testosterone and SHBG, a bell‐shaped risk pattern was seen with a decrease in odds ratio for top vs. bottom quintile of 0.82 (95% CI = 0.60–1.14; ptrend = 0.44). No support was found for the hypothesis that high levels of circulating androgens within a physiologic range stimulate development and growth of prostate cancer. © 2003 Wiley‐Liss, Inc.
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Citations
Cites
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults
Calle, E. E., Rodriguez, C., Walker-Thurmond, K., & Thun, M. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021423 · Cited by 7,696
A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum
Vermeulen, A., Verdonck, L., & Kaufman, J. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.6079 · Cited by 3,824
Stellato, R. K., Feldman, H. A., Hamdy, O., Horton, E. S., & McKinlay, J. B. (2000) · Diabetes Care · doi:10.2337/diacare.23.4.490 · Cited by 618
Ukkola, O., Gagnon, J., Rankinen, T., Thompson, P., Hong, Y., Leon, A., Rao, D., Skinner, J., Wilmore, J., & Bouchard, C. (2001) · European Journal of Endocrinology · doi:10.1530/eje.0.1450001 · Cited by 138
Cited by
Endogenous Sex Hormones and Prostate Cancer: A Collaborative Analysis of 18 Prospective Studies
Hormones, E. (2008) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djm323 · Cited by 786
Hsing, A. (2006) · Frontiers in Bioscience · doi:10.2741/1891 · Cited by 447
Testosterone for the aging male; current evidence and recommended practice
Jones, H. (2008) · Clinical Interventions in Aging · doi:10.2147/cia.s190 · Cited by 204
Thaler, M. A., Seifert-Klauss, V., & Luppa, P. B. (2015) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2015.06.005 · Cited by 125
Metadata
- Authors
- Stattin, P., Lumme, S., Tenkanen, L., Alfthan, H., Jellum, E., Hallmans, G., Thoresen, S., Hakulinen, T., Luostarinen, T., Lehtinen, M., Dillner, J., Stenman, U., & Hakama, M.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2003-10-28
- Volume
- 108
- Issue
- 3
- Pages
- 418-424
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2038199141
- Cited by
- 187
- References
- 4
- FWCI
- 8.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Stattin, P., Lumme, S., Tenkanen, L., Alfthan, H., Jellum, E., Hallmans, G., Thoresen, S., Hakulinen, T., Luostarinen, T., Lehtinen, M., Dillner, J., Stenman, U., & Hakama, M. (2004). High levels of circulating testosterone are not associated with increased prostate cancer risk: A pooled prospective study. International Journal of Cancer. https://doi.org/10.1002/ijc.11572
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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