Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging study.
Abstract
OBJECTIVE: The objective was to examine prospectively the association between low testosterone and sex hormone-binding globulin (SHBG) levels and the subsequent development of type 2 diabetes in men. RESEARCH DESIGN AND METHODS: Analyses were conducted on the cohort of the Massachusetts Male Aging Study, a population-based random sample of men aged 40-70. Of the 1,709 men enrolled in 1987-1989 (T1), 1,156 were followed up 7-10 years later (T2). Testosterone and SHBG levels at T1 were used to predict new cases of diabetes between T1 and T2. RESULTS: After controlling for potential confounders, diabetes at follow-up was predicted jointly and independently by lower baseline levels of free testosterone and SHBG. The odds ratio for future diabetes was 1.58 for a decrease of 1SD in free testosterone (4 ng/dl) and 1.89 for a 1SD decrease in SHBG (16 nmol/l), both significant at P < 0.02. CONCLUSIONS: Our prospective findings are consistent with previous, mainly cross-sectional reports, suggesting that low levels of testosterone and SHBG play some role in the development of insulin resistance and subsequent type 2 diabetes.
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Low SHBG is associated with metabolic syndrome and insulin resistance.
“Both low testosterone [38]–[40] and sex hormone binding globulin (SHBG) [41], [42] are associated with metabolic syndrome and insulin resistance.”
From Impact of Five Nights of Sleep Restriction on Glucose Metabolism, Leptin and Testosterone in Young Adult Men (2012) · cites this paper as [41]
Low testosterone levels predict insulin resistance and the future development of type 2 diabetes.
“Low testosterone levels have also been found to predict insulin resistance and the future development of type 2 diabetes (3-5).”
From Clinical and Biochemical Assessment of Hypogonadism in Men With Type 2 Diabetes (2007) · cites this paper as [4]
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- Authors
- Stellato, R. K., Feldman, H. A., Hamdy, O., Horton, E. S., & McKinlay, J. B.
- Affiliations
- New England Research Institutes (US)
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2000-04-01
- Volume
- 23
- Issue
- 4
- Pages
- 490-494
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2086247313
- Cited by
- 618
- References
- 0
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 12 · 2023: 9 · 2022: 10 · 2021: 16 · 2020: 16 · 2019: 13 · 2018: 20 · 2017: 32 · 2016: 34 · 2015: 37 · 2014: 36 · 2013: 40 · 2012: 38
- FWCI
- 8.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (7p01ag004673-05)
- National Institute on Aging (AG 04673)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 51345, R01DK044995, DK44995, R01DK051345)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- testosterone, sex hormone-binding globulin, type 2 diabetes, free testosterone, insulin resistance, middle-aged men, Massachusetts Male Aging Study, diabetes risk factors, older men
- MeSH terms
- Adult, Aged, Aging, Diabetes Mellitus, Type 2, Heart Diseases, Humans, Hypertension, Longitudinal Studies, Male, Massachusetts, Middle Aged, Predictive Value of Tests, Sex Hormone-Binding Globulin, Testosterone, Time Factors, Cohort Studies, Health Behavior, Racial Groups
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