Immunosuppressive effects of melanoma-derived heavy-chain ferritin are dependent on stimulation of IL-10 production
Abstract
Cultured melanoma cells release soluble factors that influence immune responses. Screening of a cDNA library with anti-sera from a melanoma patient identified an immunoreactive plaque, which encoded heavy-chain ferritin (H-ferritin). Previous studies have drawn attention to the immunosuppressive effects of this molecule and prompted further studies on its biochemical and functional properties in human melanoma. These studies demonstrated, firstly, that H-ferritin appeared to be secreted by melanoma cells, as shown by immunoprecipitation of a 21.5 kDa band from supernatants. It was also detected in extracts of melanoma cells by Western blotting as 43 and 64 kDa dimers and trimers of the 21.5 kDa fraction. Secondly, flow-cytometric analysis of H- and light-chain ferritin (L-ferritin) expression on melanoma showed a wide variation in L-ferritin expression and consequently of the ratio of H- to L-ferritin expression. Suppression of mitogenic responses of lymphocytes to anti-CD3 showed a correlation with the ratio of H- to L-ferritin in the supernatants and was specific for H-ferritin, as shown by inhibition studies with a monoclonal antibody (MAb) against H-ferritin. Similar results were obtained with H- and L-ferritin from other sources. Suppression of mitogenic responses of lymphocytes to anti-CD3 by H-ferritin was inhibited using a MAb against IL-10, which suggested that the immunosuppressive effect of H-ferritin was mediated by IL-10. Assays of cytokine production from anti-CD3-stimulated lymphocytes showed that H-ferritin markedly increased production of IL-10 and IFN-gamma and had only slight effects on IL-2 and IL-4 production. Our results suggest that melanoma cells may be a major source of H-ferritin and that production of the latter may account for some of the immunosuppressive effects of melanoma.
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Iron present in FTH affects the function of Tregs, as demonstrated in malignant melanoma patients.
“Indirectly, iron present in FTH affects the function of T regs as demonstrated in malignant melanoma patients.”
From Iron in infection and immunity (2020) · cites this paper as Gray et al., 2001
FTH-induced effects result in Treg activation and IL-10 secretion, mediated via CTLA-4 and PD-1.
“This results in T reg activation and IL-10 secretion, consequently, mediated via CTLA-4 (for cytotoxic Tlymphocyte-associated antigen-4) and PD-1 (for programmed death-1) (Gray et al., 2001).”
From Iron in infection and immunity (2020) · cites this paper as Gray et al., 2001
Cites
Needleman, S. B., & Wunsch, C. D. (1970) · Journal of Molecular Biology · doi:10.1016/0022-2836(70)90057-4 · Cited by 11,288 · see citing works
Jaffe, E. A., Nachman, R., Becker, C. G., & Minick, C. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107470 · Cited by 7,146 · see citing works
A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
Groux, H., O’Garra, A., Bigler, M., Rouleau, M., Antonenko, S. V., de Vries, J. E., & Roncarolo, M. G. (1997) · Nature · doi:10.1038/39614 · Cited by 3,588 · see citing works
Malefyt, R. D. W., Haanen, J. B. A. G., Spits, H., Roncarolo, M., Velde, A. A. T., Figdor, C. G., Johnson, K., KASTELEIN, R. A., Yssel, H., & de Vries, J. E. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.174.4.915 · Cited by 1,930 · see citing works
FERRITIN: STRUCTURE, GENE REGULATION, AND CELLULAR FUNCTION IN ANIMALS, PLANTS, AND MICROORGANISMS
Theil, E. C. (1987) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.56.070187.001445 · Cited by 1,337 · see citing works
Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells
Groux, H., Bigler, M., de Vries, J. D., & Roncarolo, M. (1996) · Journal of Experimental Medicine · doi:10.1084/jem.184.1.19 · Cited by 876 · see citing works
The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand.
O’Connell, J., O’Sullivan, G. C., Collins, J. K., & Shanahan, F. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.3.1075 · Cited by 873 · see citing works
Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein.
Shuai, K., Schindler, C., Prezioso, V., & Darnell, J. (1992) · Science · doi:10.1126/science.1281555 · Cited by 784 · see citing works
IL-6 and APPs: anti-inflammatory and immunosuppressive mediators.
Tilg, H., Dinarello, C., & Mier, J. (1997) · Immunology today (Amsterdam. Regular ed.) · doi:10.1016/s0167-5699(97)01103-1 · Cited by 687 · see citing works
Current protocols in immunology
Wisdom, G. B. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80333-p · Cited by 590 · see citing works
On ferritin heterogeneity. Further evidence for heteropolymers.
Arosio, P., Adelman, T. G., & Drysdale, J. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34741-5 · Cited by 457 · see citing works
Self-citationBodmer, S., Strommer, K., Frei, K., Siepl, C., de Tribolet, N., Heid, I., & Fontana, A. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.143.10.3222 · Cited by 386 · see citing works
Zhang, X. D., Franco, A., Myers, K., Gray, C. P., Nguyen, T., & Hersey, P. (1999) · PubMed · Cited by 385 · see citing works
Self-citationKono, K., Salazar‐Onfray, F., Petersson, M., Hansson, J., Masucci, G. V., Wasserman, K., Nakazawa, T., Anderson, P., & Kiessling, R. W. (1996) · European Journal of Immunology · doi:10.1002/eji.1830260620 · Cited by 360 · see citing works
Matsuda, M., Salazar, F., Petersson, M., Masucci, G. V., Hansson, J., Pisa, P., Zhang, Q. J., Masucci, M. G., & Kiessling, R. W. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.6.2371 · Cited by 306 · see citing works
Structural and functional relationships of human ferritin H and L chains deduced from cDNA clones.
Boyd, D. H., Vecoli, C., Belcher, D. M., Jain, S. K., & Drysdale, J. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39094-4 · Cited by 240 · see citing works
Modulation of T-cell function by gliomas
Roszman, T. L., Elliott, L. H., & Brooks, W. H. (1991) · Immunology Today · doi:10.1016/0167-5699(91)90068-5 · Cited by 239 · see citing works
Chen, Q., Daniel, V. C., Maher, D. W., & Hersey, P. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910560524 · Cited by 234 · see citing works
Self-citationCavani, A., Nasorri, F., Prezzi, C., Sebastiani, S., Albanesi, C., & Girolomoni, G. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00881.x · Cited by 232 · see citing works
T-regulatory 1 cells: A novel subset of CD4+ T cells with immunoregulatory properties
Levings, M. K., & Roncarolo, M. (2000) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2000.106635 · Cited by 176 · see citing works
Production and characterization of recombinant heteropolymers of human ferritin H and L chains
Santambrogio, P., Levi, S., Cozzi, A., Rovida, E., Albertini, A., & Arosio, P. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31451-0 · Cited by 161 · see citing works
Self-citationHAZARD, J. T., & Drysdale, J. W. (1977) · Nature · doi:10.1038/265755a0 · Cited by 161 · see citing works
Suppressive Effect of Ferritin on in Vitro Lymphocyte Function
Matzner, Y., Hershko, C., Polliack, A., Konijn, A. M., & Izak, G. (1979) · British Journal of Haematology · doi:10.1111/j.1365-2141.1979.tb01142.x · Cited by 158 · see citing works
Serum ferritin as a guide to therapy in neuroblastoma.
HANN, H.-W. L., Levy, H. M., & Evans, A. E. (1980) · PubMed · Cited by 135 · see citing works
Structure of gene and pseudogenes of human apoferritin H
Costanzo, F. S., Colombo, M. P., Staempfli, S., Santoro, C., Marone, M., Frank, R., Delius, H., & Cortese, R. (1986) · Nucleic Acids Research · doi:10.1093/nar/14.2.721 · Cited by 126 · see citing works
Curry, B. J., Myers, K., & Hersey, P. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.5.1760 · Cited by 120 · see citing works
Self-citationGoto, S., Sato, M., Kaneko, R., Itoh, M., Sato, S., & Takeuchi, S. (1999) · Cancer Immunology Immunotherapy · doi:10.1007/s002620050620 · Cited by 105 · see citing works
Costanzo, F. S., Santoro, C., Colantuoni, V., Bensi, G., Raugei, G., Romano, V., & Cortese, R. (1984) · The EMBO Journal · doi:10.1002/j.1460-2075.1984.tb01756.x · Cited by 89 · see citing works
Inhibition of interleukin 2 production by factors released from tumor cells.
Hersey, P., Bindon, C. I., Czerniecki, M., Spurling, A., Wass, J. A. H., & McCarthy, W. H. (1983) · The Journal of Immunology · doi:10.4049/jimmunol.131.6.2837 · Cited by 84 · see citing works
Self-citationFargion, S., Fracanzani, A. L., Brando, B., Arosio, P., Levi, S., & Fiorelli, G. (1991) · Blood · doi:10.1182/blood.v78.4.1056.1056 · Cited by 78 · see citing works
Self-citationBroxmeyer, H., Lu, L., BICKNELL, D. S., Williams, D. E., Cooper, S. H., Levi, S., Salfeld, J., & Arosio, P. (1986) · Blood · doi:10.1182/blood.v68.6.1257.1257 · Cited by 71 · see citing works
Self-citationAnti-melanoma effects of R24, a monoclonal antibody against GD3 ganglioside
Nasi, M. L., Meyers, M. L., Livingston, P. O., Houghton, A. N., & Chapman, P. B. (1997) · Melanoma Research · doi:10.1097/00008390-199708001-00024 · Cited by 68 · see citing works
Linnemeyer, P. A., & Pollack, S. B. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.9.3747 · Cited by 67 · see citing works
Functional roles of the ferritin receptors of human liver, hepatoma, lymphoid and erythroid cells
Moss, D., Powell, L. W., Halliday, J. W., Fargion, S. R., Cappellini, M. D., Fracanzani, A. L., Levi, S., & Arosio, P. (1992) · Journal of Inorganic Biochemistry · doi:10.1016/0162-0134(92)84067-w · Cited by 63 · see citing works
Self-citationDifferential effect of isolated placental isoferritins on in vitro T‐lymphocyte function
Matzner, Y., Konijn, A. M., Shlomai, Z., & Ben‐Bassat, H. (1985) · British Journal of Haematology · doi:10.1111/j.1365-2141.1985.tb07331.x · Cited by 58 · see citing works
Roth, J. A., Grimm, E. A., Gupta, R., & Ames, R. S. (1982) · The Journal of Immunology · doi:10.4049/jimmunol.128.5.1955 · Cited by 54 · see citing works
Neuroblastomas contain iron-rich ferritin
Iancu, T. C., Shiloh, H., & Kedar, A. (1988) · Cancer · doi:10.1002/1097-0142(19880615)61:12 · Cited by 53 · see citing works
Serum ferritin as a clinical marker for renal cell carcinoma: influence of tumor volume
Partin, A. W., Criley, S. R., Steiner, M. S., Hsieh, K., Simons, J. W., Lumadue, J. A., Carter, H. B., & Marshall, F. F. (1995) · Urology · doi:10.1016/0090-4295(95)80007-7 · Cited by 47 · see citing works
Human ferritin H and L sequences lie on ten different chromosomes
McGill, J., Naylor, S. L., Sakaguchi, A. Y., Moore, C., Boyd, D. H., Barrett, K., Shows, T. B., & Drysdale, J. (1987) · Human Genetics · doi:10.1007/bf00283053 · Cited by 46 · see citing works
Transient overexpression of human H- and L-ferritin chains in COS cells
Corsi, B., Perrone, F., Bourgeois, M., Beaumont, C., Panzeri, C., Cozzi, A., Sangregorio, R., Santambrogio, P., Albertini, A., Arosio, P., et al. (1998) · Biochemical Journal · doi:10.1042/bj3300315 · Cited by 43 · see citing works
Self-citationAusubel, F. M. (1999) · Cited by 42 · see citing works
A Role for Ferritin in Hematopoiesis and the Immune System
Morikawa, K., Oseko, F., & Morikawa, S. (1995) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428199509059641 · Cited by 39 · see citing works
Integration of receptor-mediated signals in T cells by transmembrane adaptor proteins
Schraven, B. L., Marie‐Cardine, A., Hübener, C., Bruyns, E., & Ding, I. (1999) · Immunology Today · doi:10.1016/s0167-5699(99)01519-4 · Cited by 36 · see citing works
Cavanna, F., Ruggeri, G., Iacobello, C., Chieregatti, G., Murador, E., Albertini, A., & Arosio, P. (1983) · Clinica Chimica Acta · doi:10.1016/0009-8981(83)90373-x · Cited by 32 · see citing works
Self-citationAnalysis of Flow Cytometry Data
Sharrow, S. O. (1991) · Current Protocols in Immunology · doi:10.1002/0471142735.im0502s00 · Cited by 30 · see citing works
Rosén, H., Ausch, C., Reinerova, M., Zaspin, E., Renner, K., Rosen, A. C., Schiessel, R., & Moroz, C. (1998) · Cancer Letters · doi:10.1016/s0304-3835(98)00017-2 · Cited by 25 · see citing works
Serial Determination of Serum Ferritin Levels in Patients with Malignant Melanoma
Luger, T. A., Linkesch, W., Knobler, R., & Kokoschka, E. M. (2009) · Oncology · doi:10.1159/000225740 · Cited by 21 · see citing works
Elevated Expression of Ferritin H-Chain mRNA in Metastatic Ovarian Tumor
Tripathi, P., & Chatterjee, S. K. (1996) · Cancer Investigation · doi:10.3109/07357909609076897 · Cited by 21 · see citing works
Wigginton, J. M. (1995) · Medical Hypotheses · doi:10.1016/0306-9877(95)90075-6 · Cited by 20 · see citing works
Sequence of a cDNA encoding the ferritin h-chain from an 11-week-old human fetal brain
Dhar, M. S., Chauthaiwale, V. M., & Joshi, J. G. (1993) · Gene · doi:10.1016/0378-1119(93)90380-l · Cited by 20 · see citing works
Post-transcriptional Regulation of H-ferritin mRNA
Ai, L.-S., & Chau, L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.30209 · Cited by 16 · see citing works
Dezza, L., Cazzola, M., Bergamaschi, G., Carlo‐Stella, C., Pedrazzoli, P., & Recalde, H. R. (1988) · British Journal of Haematology · doi:10.1111/j.1365-2141.1988.tb04216.x · Cited by 14 · see citing works
Immunogenicity of CD63 in a patient with melanoma
Smith, M., Bleijs, R., Radford, K. J., & Hersey, P. (1997) · Melanoma Research · doi:10.1097/00008390-199708001-00025 · Cited by 12 · see citing works
Self-citationMoroz, C., Shterman, N., Kupfer, B., & Ginzburg, I. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.9.3282 · Cited by 10 · see citing works
Shterman, N., Kupfer, B., & Moroz, C. (1989) · PubMed · Cited by 8 · see citing works
Brotherick, I., Shenton, B. K., Kirby, J. A., Rigg, K., Palmer, J., Yeaman, S. J., & Lennard, T. W. J. (1993) · Surgical Oncology · doi:10.1016/0960-7404(93)90013-o · Cited by 4 · see citing works
Inhibition of Lymphocyte Function by Head and Neck Carcinoma Cell Line Soluble Factors
Bailet, J. W., Lichtenstein, A. K., Chen, G., & Mickel, R. A. (1997) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archotol.1997.01900080089011 · Cited by 4 · see citing works
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Ferritins: A family of molecules for iron storage, antioxidation and more
Arosio, P., Ingrassia, R., & Cavadini, P. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.09.004 · Cited by 886 · see citing works
Self-citationSerum ferritin: Past, present and future
Wang, W., Knovich, M. A., Coffman, L. G., Torti, F. M., & Torti, S. V. (2010) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2010.03.011 · Cited by 882 · see citing works
Rosário, C., Zandman‐Goddard, G., Meyron‐Holtz, E. G., D’Cruz, D. P., & Shoenfeld, Y. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-185 · Cited by 466 · see citing works
Iron in infection and immunity
Nairz, M., & Weiss, G. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100864 · Cited by 359 · see citing works
Iron-withholding strategy in innate immunity
Ong, S. T., Shan Ho, J. Z., Ho, B., & Ding, J. L. (2006) · Immunobiology · doi:10.1016/j.imbio.2006.02.004 · Cited by 269 · see citing works
New functions for an iron storage protein: The role of ferritin in immunity and autoimmunity
Recalcati, S., Invernizzi, P., Arosio, P., & Cairo, G. (2008) · Journal of Autoimmunity · doi:10.1016/j.jaut.2007.11.003 · Cited by 259 · see citing works
Self-citationThe significance of ferritin in cancer: Anti-oxidation, inflammation and tumorigenesis
Alkhateeb, A. A., & Connor, J. R. (2013) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2013.07.002 · Cited by 247 · see citing works
Overcoming Immune Evasion in Melanoma
Eddy, K., & Chen, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21238984 · Cited by 230 · see citing works
Ferritin – from iron, through inflammation and autoimmunity, to COVID-19
Mahroum, N., Alghory, A., Kiyak, Z., Alwani, A., Seida, R., Alrais, M., & Shoenfeld, Y. (2021) · Journal of Autoimmunity · doi:10.1016/j.jaut.2021.102778 · Cited by 208 · see citing works
Regulated secretion of glycosylated human ferritin from hepatocytes
Ghosh, S., Hevi, S., & Chuck, S. L. (2003) · Blood · doi:10.1182/blood-2003-09-3050 · Cited by 130 · see citing works
Heavy chain ferritin activates regulatory T cells by induction of changes in dendritic cells
Gray, C. P., Arosio, P., & Hersey, P. (2002) · Blood · doi:10.1182/blood.v99.9.3326 · Cited by 118 · see citing works
Self-citationEmerging and Dynamic Biomedical Uses of Ferritin
Chiou, B., & Connor, J. R. (2018) · Pharmaceuticals · doi:10.3390/ph11040124 · Cited by 119 · see citing works
Chemnitz, J. M., Driesen, J., Claßen, S., Riley, J. L., Debey, S., Beyer, M., Popov, A., Zander, T., & Schultze, J. L. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3252 · Cited by 100 · see citing works
Iron Uptake Mediated by Binding of H-Ferritin to the TIM-2 Receptor in Mouse Cells
Han, J., Seaman, W. E., Di, X., Wang, W., Willingham, M. C., Torti, F. M., & Torti, S. V. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023800 · Cited by 93 · see citing works
Macrophage and epithelial cell H-ferritin expression regulates renal inflammation
Bolisetty, S., Zarjou, A., Hull, T. D., Traylor, A., Perianayagam, A., Joseph, R., Kamal, A., Arosio, P., Soares, M. P., Jeney, V., et al. (2015) · Kidney International · doi:10.1038/ki.2015.102 · Cited by 90 · see citing works
Self-citationThe role of iron in tumour cell proliferation
Steegmann-Olmedillas, J. L. (2011) · Clinical and Translational Oncology · doi:10.1007/s12094-011-0621-1 · Cited by 84 · see citing works
Baldi, A., Lombardi, D., Russo, P., Palescandolo, E., Luca, A. D., Santini, D., Baldi, F., Rossiello, L., Dell’Anna, M. L., Mastrofrancesco, A., et al. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0631 · Cited by 82 · see citing works
Liu, X., Madhankumar, A. B., Slagle‐Webb, B., Sheehan, J. M., Surguladze, N., & Connor, J. R. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-1375 · Cited by 76 · see citing works
Vallejo, A. N., Yang, H., Klimiuk, P. A., Weyand, C. M., & Goronzy, J. J. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.4.1732 · Cited by 75 · see citing works
Laskar, A., Ghosh, M., Khattak, S. I., Li, W., & Yuan, X. (2012) · Nanomedicine · doi:10.2217/nnm.11.148 · Cited by 75 · see citing works
Zoll, J., Melchers, W. J. G., Galama, J. M. D., & van Kuppeveld, F. J. M. (2002) · Journal of Virology · doi:10.1128/jvi.76.19.9664-9672.2002 · Cited by 74 · see citing works
Sengupta, R., Burbassi, S., Shimizu, S., Cappello, S., Vallee, R. B., Rubin, J. B., & Meucci, O. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5865-08.2009 · Cited by 73 · see citing works
A novel view of ferritin in cancer
Pandya, B., & Connor, J. R. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188917 · Cited by 72 · see citing works
Macrophage activation syndrome: Serological markers and treatment with anti-thymocyte globulin
Coca, A., Bundy, K. W., Marston, B. A., Huggins, J., & Looney, R. J. (2009) · Clinical Immunology · doi:10.1016/j.clim.2009.02.005 · Cited by 69 · see citing works
COVID-19—A Theory of Autoimmunity Against ACE-2 Explained
McMillan, P., Dexhiemer, T., Neubig, R. R., & Uhal, B. D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.582166 · Cited by 63 · see citing works
Iron-mediated oxidative stress plays an essential role in ferritin-induced cell death
Bresgen, N., Jaksch, H., Lacher, H., Ohlenschläger, I., Uchida, K., & Eckl, P. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.02.019 · Cited by 62 · see citing works
Cancer Biomarker Discovery: The Entropic Hallmark
Berretta, R. E., & Moscato, P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012262 · Cited by 53 · see citing works
Chen, T., Song, D., Min, Z., Wang, X., Gu, Y. X., Wei, B., Yao, J., Chen, K., Jiang, Z., Xie, H., et al. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-14 · Cited by 48 · see citing works
Ruscitti, P., Cipriani, P., Benedetto, P. D., Liakouli, V., Carubbi, F., Berardicurti, O., Ciccia, F., Guggino, G., Triolo, G., & Giacomelli, R. (2017) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2017.1372194 · Cited by 44 · see citing works
Sakamoto, S., Kawabata, H., Masuda, T., Uchiyama, T., Mizumoto, C., Ohmori, K., Koeffler, H. P., Kadowaki, N., & Takaori‐Kondo, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139915 · Cited by 40 · see citing works
Tesfay, L., Huhn, A. J., Hatcher, H., Torti, F. M., & Torti, S. V. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040030 · Cited by 39 · see citing works
Ruscitti, P., Ciccia, F., Cipriani, P., Guggino, G., Benedetto, P. D., Rizzo, A., Liakouli, V., Berardicurti, O., Carubbi, F., Triolo, G., et al. (2015) · Clinical & Experimental Immunology · doi:10.1111/cei.12738 · Cited by 32 · see citing works
Prognostic evaluation of serum ferritin in acute exacerbation of idiopathic pulmonary fibrosis
Enomoto, N., Oyama, Y., Enomoto, Y., Mikamo, M., Karayama, M., Hozumi, H., Suzuki, Y., Kono, M., Furuhashi, K., Fujisawa, T., et al. (2018) · The Clinical Respiratory Journal · doi:10.1111/crj.12918 · Cited by 32 · see citing works
A transcriptomic investigation of handicap models in sexual selection
Wenzel, M. A., Webster, L. M. I., Paterson, S., Mougeot, F., Martínez‐Padilla, J., & Piertney, S. B. (2012) · Behavioral Ecology and Sociobiology · doi:10.1007/s00265-012-1442-0 · Cited by 31 · see citing works
Ferritin—a mediator of apoptosis?
Bresgen, N., Ohlenschläger, I., Fiedler, B., Wacht, N., Zach, S., Dunkelmann, B., Arosio, P., Kuffner, E., Lottspeich, F., & Eckl, P. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21009 · Cited by 29 · see citing works
Self-citationFerritin heavy chain supports stability and function of the regulatory T cell lineage
Wu, Q., Carlos, A. R., Braza, F., Bergman, M., Kitoko, J. Z., Bastos-Amador, P., Cuadrado, E., Martins, R., de Oliveira, B. S. P., Martins, V. C., et al. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00064-x · Cited by 29 · see citing works
Ferritin and FasL (CD95L) mediate density dependent apoptosis in primary rat hepatocytes
Bresgen, N., Ohlenschläger, I., Wacht, N., Afazel, S., Ladurner, G., & Eckl, P. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21555 · Cited by 28 · see citing works
Sakamoto, S., Kawabata, H., Kanda, J., Uchiyama, T., Mizumoto, C., Kondo, T., Yamashita, K., Ichinohe, T., Ishikawa, T., Kadowaki, N., et al. (2012) · International Journal of Hematology · doi:10.1007/s12185-012-1229-0 · Cited by 28 · see citing works
Serrano, I., Luque, A., & Aran, J. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00892 · Cited by 28 · see citing works
Chao, K., Chang, C.-C., Chiou, H., & Chang, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144238 · Cited by 26 · see citing works
Immune Regulation by the TIM Gene Family
de Souza, A. J., & Kane, L. (2006) · Immunologic Research · doi:10.1385/ir:36:1:147 · Cited by 19 · see citing works
Predicting chemotherapy-induced thrombocytopenia in cancer patients with solid tumors or lymphoma
Razzaghdoust, A., Mofid, B., & Zangeneh, M. (2019) · Journal of Oncology Pharmacy Practice · doi:10.1177/1078155219861423 · Cited by 17 · see citing works
Effect of Heme Oxygenase-1 on Melanoma Development in Mice—Role of Tumor-Infiltrating Immune Cells
Waś, H., Cichoń, T., Smolarczyk, R., Lackowska, B., Mazur-Biały, A. I., Mazur, M., Szade, A., Dominik, P., Mazan, M. M., Kotlinowski, J., et al. (2020) · Antioxidants · doi:10.3390/antiox9121223 · Cited by 14 · see citing works
Bouwhuis, M. G., Collette, S., Suciu, S., de Groot, E. R., Kruit, W. H. J., ten Hagen, T. L. M., Aarden, L. A., Eggermont, A. M. M., & Swaak, A. J. G. (2011) · Melanoma Research · doi:10.1097/cmr.0b013e328346c17f · Cited by 13 · see citing works
Neonatal Pulmonary Host Defense
Good, M. L., Kolls, J. K., & Empey, K. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-35214-7.00130-x · Cited by 13 · see citing works
Reikvam, H., Rolfsnes, M. G., Rolsdorph, L. Å., Sandnes, M., Selheim, F., Hernandez-Valladares, M., & Bruserud, Ø. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125744 · Cited by 12 · see citing works
SARS–CoV-2 Mediated Hyperferritinemia and Cardiac Arrest: Preliminary Insights
VasanthiDharmalingam, P., Karuppagounder, V., Watanabe, K., Karmouty‐Quintana, H., Palaniyandi, S. S., Guha, A., & Thandavarayan, R. A. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.01.014 · Cited by 13 · see citing works
Zahalka, M. A., Barak, V., Traub, L., & Moroz, C. (2003) · The FASEB Journal · doi:10.1096/fj.02-0960fje · Cited by 12 · see citing works
Aspects of cancer immunotherapy
McKenzie, I. F. C., Apostolopoulos, V., Plebanski, M., Pietersz, G. A., & Loveland, B. E. (2003) · Immunology and Cell Biology · doi:10.1046/j.0818-9641.2002.01140.x · Cited by 10 · see citing works
Foka, P., Dimitriadis, A., Karamichali, E., Kochlios, E., Eliadis, P., Valiakou, V., Koskinas, J. S., Mamalaki, A., & Georgopoulou, U. (2021) · Cells · doi:10.3390/cells10092251 · Cited by 8 · see citing works
Hohaus, S., Giachelia, M., Cuccaro, A., Voso, M. T., & Leone, G. G. M. (2013) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.2013007765 · Cited by 8 · see citing works
Messmer, D., Telusma, G., Wasil, T., Messmer, B. T., Allen, S. L., Rai, K. R., & Chiorazzi, N. (2004) · Molecular Medicine · doi:10.2119/2005-00011.messmer · Cited by 7 · see citing works
Absmaier-Kijak, M., Iuliano, C., Kaesler, S., Biedermann, T., Posch, C., & Brockow, K. (2024) · Cancers · doi:10.3390/cancers16061226 · Cited by 6 · see citing works
Paiva, N. F., Rios, W. M., Antonio, G. P., Umino, G. M., Ferreira, M. P., Brandão, I. T., Ciampo, J. O. D., Bentley, M. V. L. B., Casagrande, R., Verri, W. A., Jr., et al. (2024) · BioNanoScience · doi:10.1007/s12668-024-01676-7 · Cited by 6 · see citing works
Yaacob, E. N., Geest, B. G. D., Goethals, J., Bajek, A., Dierckens, K. R., Bossier, P., & Vanrompay, D. C. G. (2018) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2018.09.001 · Cited by 6 · see citing works
Liu, X., Liang, Y., Shen, Z., Wei, L., Yang, J., Piao, Y., Sang, W., Li, P., & Wang, L. (2023) · Cancer Medicine · doi:10.1002/cam4.5820 · Cited by 3 · see citing works
Liu, W., Chen, Q., Mao, M., Han, R., Liu, Y., & Wang, X. (2020) · Translational Cancer Research · doi:10.21037/tcr-20-966 · Cited by 2 · see citing works
Neonatal Pulmonary Host Defense
Empey, K. M., & Kolls, J. K. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-3479-7.10159-4 · Cited by 2 · see citing works
Ferritin and hiperferritinemic syndrome: Its impact on the seriously ill; current concepts
Esper, R. C., Pérez, C. P., Mendoza, A. D. Z., Márquez, J. M. M., Maldonado, R. N., Meza-Ayala, C. M., Córdova, D. M. C., & Córdova, C. A. C. (2015) · Medicina Crítica · Cited by 2 · see citing works
Relação entre os níveis de ferritina e o prognóstico da COVID-19
Júnior, E. C. S. D. S., Medeiros, A. P. D. F., Silva, I. V. E., & Silva, R. D. F. E. (2022) · Revista de Medicina · doi:10.11606/issn.1679-9836.v101i1e-190974 · Cited by 1 · see citing works
Majid, S., Khan, M. S., Nisar, N., Bhat, J. A., Haq, I., & Khan, M. S. (2023) · Journal of Circulating Biomarkers · doi:10.33393/jcb.2023.2480 · Cited by 1 · see citing works
Development and appraisal of MRI contrast agents for the in vivo analysis of stem cell grafts
Williams, S. (2012) · ORCA Online Research @Cardiff (Cardiff University) · Cited by 1 · see citing works
Non-transferrin-bound iron in hematopoietic stem cell transplantation
Sahlstedt, L. (2015) · Työväentutkimus Vuosikirja
Cell response to imaging contrast agents suggested for atherosclerotic plaque imaging
Laskar, A. (2013) · DiVA (Linkoping University)
Armani, A. L. C., Prado, S. B. R., & Malachias, V. T. (2014) · CRC Press eBooks · doi:10.1201/b16653-31
(2001) · doi:10.1201/b14262-1
Martínez, W. A. R., & Casanova, M. (2024) · Revista Médicas UIS · doi:10.18273/revmed.v37n2-2024009
Zhong, P., Sang, X., Yu, Y., & wang, Z. (2026) · Immunity Inflammation and Disease · doi:10.1002/iid3.70358
Hyperferritinemic Syndromes and Long COVID
Stoian, M. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1014823
(2003) · PubMed · Cited by 110 · see citing works
Self-citation
- Authors
- Gray, C. P., Franco, A. V., Arosio, P., & Hersey, P.
- Corresponding author
- Hersey, Peter
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2001
- Volume
- 92
- Issue
- 6
- Pages
- 843-850
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2048961365
- Cited by
- 70
- References
- 59
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 6 · 2014: 1 · 2013: 4 · 2012: 6
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Cancer (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- heavy chain ferritin, melanoma, immunosuppression, IL-10, lymphocyte mitogen response, anti-CD3 stimulation, interferon-gamma, cytokine production
- MeSH terms
- Antibodies, Monoclonal, Base Sequence, Dose-Response Relationship, Drug, Ferritins, Flow Cytometry, Humans, Immunosuppressive Agents, Interferon-gamma, Interleukin-2, Liver, Lymphocytes, Melanoma, Molecular Sequence Data, Myocardium, Plasmids, Precipitin Tests, Recombinant Proteins, Sequence Homology, Nucleic Acid, T-Lymphocytes, Tissue Distribution, Tumor Cells, Cultured, Blotting, Western, Interleukin-4, Interleukin-10, CD3 Complex, Sequence Analysis, DNA, DNA, Complementary, Dimerization
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