The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Induction of a metastatogenic tumor cell type by neurotransmitters and its pharmacological inhibition by established drugs
Open accessAbstract
The active migration of tumor cells, a crucial requirement for metastasis development and cancer progression, is regulated by signal substances including neurotransmitters. We investigated the migration of tumor cells within a three‐dimensional collagen matrix using time‐lapse videomicroscopy and computer‐assisted analysis of the migration path. Tumor cell migration is induced by norepinephrine, dopamine and substance P. We show that this induced migration, using MDA‐MB‐468 breast and PC‐3 prostate carcinoma cells, can be inhibited by using specific, clinically established receptor antagonists to the β2‐adrenoceptor, the D2 receptor, or the neurokinin‐1 receptor, respectively. All of the investigated neurotransmitters significantly activated the cyclic adenosine‐monophosphate response element binding protein (CREB). Furthermore, microarray analysis revealed changes of gene expression toward a highly motile tumor cell type, including an upregulation of the α2 integrin, which is an essential adhesion receptor for collagen in migration. The gene for the tumor suppressor gelsolin was downregulated. These 2 critical alterations were confirmed on the protein level by flow‐cytometry and immunoblotting, respectively. Neurotransmitters thus induce a metastatogenic tumor cell type by directly regulating gene expression and increased migratory activity, which can be prevented by established neurotransmitter antagonists. © 2004 Wiley‐Liss, Inc.
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The sympathetic nervous system induces a metastatic switch in primary breast cancer
Sloan, E. K., Priceman, S. J., Cox, B. F., Yu, S., Pimentel, M. A., Tangkanangnukul, V., Arevalo, J. M. G., Morizono, K., Karanikolas, B. D. W., Wu, L., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0522 · Cited by 930
Sympathetic nervous system regulation of the tumour microenvironment
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“Interestingly, non-selective β1/2-receptor antagonists like propranolol have shown to decrease tumor growth and migration of cancer cells [68, 70, 72, 176].”
BackgroundTargeting key steps in metastatic tumour progression
Eccles, S. A. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2004.12.001 · Cited by 73
Metadata
- Authors
- Lang, K., Drell, T. L., Lindecke, A., Niggemann, B., Kaltschmidt, C., Zaenker, K. S., & Entschladen, F.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2004-08-17
- Volume
- 112
- Issue
- 2
- Pages
- 231-238
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2165157874
- Cited by
- 256
- References
- 44
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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