Sympathetic nervous system regulation of the tumour microenvironment
Open accessAbstract
The peripheral autonomic nervous system (ANS) is known to regulate gene expression in primary tumours and their surrounding microenvironment. Activation of the sympathetic division of the ANS in particular modulates gene expression programmes that promote metastasis of solid tumours by stimulating macrophage infiltration, inflammation, angiogenesis, epithelial-mesenchymal transition and tumour invasion, and by inhibiting cellular immune responses and programmed cell death. Haematological cancers are modulated by sympathetic nervous system (SNS) regulation of stem cell biology and haematopoietic differentiation programmes. In addition to identifying a molecular basis for physiologic stress effects on cancer, these findings have also identified new pharmacological strategies to inhibit cancer progression in vivo.
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Findings from animal and in vitro studies back up the human data on psychosocial factors and tumor progression.
“Parallel findings in animal and in vitro models support these data [11, 16–22].”
From Living Well: Protocol for a web-based program to improve quality of life in rural and urban ovarian cancer survivors (2024) · cites this paper as [22]
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Microenvironmental regulation of tumor progression and metastasis
Quail, D. F., & Joyce, J. A. (2013) · Nature Medicine · doi:10.1038/nm.3394 · Cited by 7,994 · see citing works
Cytokine-mediated regulation of CXCR4 expression in human neutrophils
Nagase, H., Miyamasu, M., Yamaguchi, M., Imanishi, M., Tsuno, N. H., Matsushima, K., Yamamoto, K., Morita, Y., & Hirai, K. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.4.711 · Cited by 4,713 · see citing works
Elenkov, I. J., Wilder, R. L., Chrousos, G. P., & Vizi, E. S. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01470-4 · Cited by 2,252 · see citing works
Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow
Katayama, Y., Battista, M., Kao, W.-M., Hidalgo, A., Peired, A. J., Thomas, S. A., & Frenette, P. S. (2006) · Cell · doi:10.1016/j.cell.2005.10.041 · Cited by 1,412 · see citing works
Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
Thaker, P. H., Han, L. Y., Kamat, A. A., Arevalo, J. M., Takahashi, R., Lu, C., Jennings, N. B., Armaiz-Pena, G., Bankson, J. A., Ravoori, M., et al. (2006) · Nature Medicine · doi:10.1038/nm1447 · Cited by 1,320 · see citing works
Self-citationHaematopoietic stem cell release is regulated by circadian oscillations
Méndez‐Ferrer, S., Lucas, D., Battista, M., & Frenette, P. S. (2008) · Nature · doi:10.1038/nature06685 · Cited by 1,310 · see citing works
Autonomic nerve development contributes to prostate cancer progression
Magnon, C., Hall, S. J., Lin, J., Xue, X., Gerber, L., Freedland, S. J., & Frenette, P. S. (2013) · Science · doi:10.1126/science.1236361 · Cited by 1,287 · see citing works
Circadian control of the immune system
Scheiermann, C., Kunisaki, Y., & Frenette, P. S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3386 · Cited by 1,135 · see citing works
Myocardial infarction accelerates atherosclerosis
Dutta, P., Courties, G., Wei, Y., Leuschner, F., Gorbatov, R., Robbins, C. S., Iwamoto, Y., Thompson, B. D., Carlson, A. L., Heidt, T., et al. (2012) · Nature · doi:10.1038/nature11260 · Cited by 1,084 · see citing works
Do stress-related psychosocial factors contribute to cancer incidence and survival?
Chida, Y., Hamer, M., Wardle, J., & Steptoe, A. (2008) · Nature Clinical Practice Oncology · doi:10.1038/ncponc1134 · Cited by 1,072 · see citing works
The influence of bio-behavioural factors on tumour biology: pathways and mechanisms
Antoni, M. H., Lutgendorf, S. K., Cole, S. W., Dhabhar, F. S., Sephton, S. E., McDonald, P. G., Stefanek, M., & Sood, A. K. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1820 · Cited by 981 · see citing works
Self-citationHuman Physiology : From Cells to Systems
Sherwood, L. (1989) · Cited by 968 · see citing works
The sympathetic nervous system induces a metastatic switch in primary breast cancer
Sloan, E. K., Priceman, S. J., Cox, B. F., Yu, S., Pimentel, M. A., Tangkanangnukul, V., Arevalo, J. M. G., Morizono, K., Karanikolas, B. D. W., Wu, L., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0522 · Cited by 930 · see citing works
Self-citationReciprocal regulation of the neural and innate immune systems
Irwin, M. R., & Cole, S. W. (2011) · Nature Reviews Immunology · doi:10.1038/nri3042 · Cited by 910 · see citing works
Self-citationChronic variable stress activates hematopoietic stem cells
Heidt, T., Sager, H. B., Courties, G., Dutta, P., Iwamoto, Y., Zaltsman, A., von zur Muhlen, C., Bode, C., Fricchione, G. L., Denninger, J., et al. (2014) · Nature Medicine · doi:10.1038/nm.3589 · Cited by 803 · see citing works
Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia
Rosas‐Ballina, M., Ochani, M., Parrish, W. R., Ochani, K., Harris, Y., Huston, J. M., Chavan, S. S., & Tracey, K. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803237105 · Cited by 757 · see citing works
Molecular Pathways: Beta-Adrenergic Signaling in Cancer
Cole, S. W., & Sood, A. K. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0641 · Cited by 691 · see citing works
Self-citationDenervation suppresses gastric tumorigenesis
Zhao, C., Hayakawa, Y., Kodama, Y., Muthupalani, S., Westphalen, C. B., Andersen, G. T., Flatberg, A., Johannessen, H., Friedman, R. A., Renz, B. W., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009569 · Cited by 674 · see citing works
Powell, N. D., Sloan, E. K., Bailey, M. T., Arevalo, J. M. G., Miller, G. E., Chen, E., Kobor, M. S., Reader, B. F., Sheridan, J. F., & Cole, S. W. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310655110 · Cited by 588 · see citing works
Self-citationSchommer, N. C., Hellhammer, D. H., & Kirschbaum, C. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000035721.12441.17 · Cited by 561 · see citing works
Beta Blockers and Breast Cancer Mortality: A Population- Based Study
Barron, T. I., Connolly, R. M., Sharp, L., Bennett, K., & Visvanathan, K. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.33.5422 · Cited by 532 · see citing works
Stress hormone-mediated invasion of ovarian cancer cells
Sood, A. K., Bhatty, R., Kamat, A. A., Landen, C. N., Han, L., Thaker, P. H., Li, Y., Gershenson, D. M., Lutgendorf, S., & Cole, S. W. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1698 · Cited by 491 · see citing works
Self-citationExploiting the critical perioperative period to improve long-term cancer outcomes
Horowitz, M., Neeman, E., Sharon, E., & Ben-Eliyahu, S. (2015) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2014.224 · Cited by 487 · see citing works
Phagocyte-derived catecholamines enhance acute inflammatory injury
Flierl, M. A., Rittirsch, D., Nadeau, B. A., Chen, A. J., Sarma, J. V., Zetoune, F. S., McGuire, S. R., List, R. P., Day, D. E., Hoesel, L. M., et al. (2007) · Nature · doi:10.1038/nature06185 · Cited by 475 · see citing works
Melhem‐Bertrandt, A., Chávez‐MacGregor, M., Lei, X. J., Brown, E. N., Lee, R. T., Meric‐Bernstam, F., Sood, A. K., Conzen, S. D., Hortobágyi, G. N., & Gonzalez-Angulo, A. M. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.33.4441 · Cited by 467 · see citing works
Self-citationPowe, D. G., Voss, M. J., Zänker, K. S., Habashy, H. O., Green, A. R., Ellis, I. O., & Entschladen, F. (2010) · Oncotarget · doi:10.18632/oncotarget.197 · Cited by 462 · see citing works
Why Zebras Don't Get Ulcers: An Updated Guide to Stress, Stress Related Diseases, and Coping
Sapolsky, R. M. (1998) · Medical Entomology and Zoology · Cited by 444 · see citing works
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
Hara, M. R., Kovacs, J. J., Whalen, E. J., Rajagopal, S., Strachan, R. T., Grant, W., Towers, A. J., Williams, B., Lam, C. M., Xiao, K., et al. (2011) · Nature · doi:10.1038/nature10368 · Cited by 420 · see citing works
Cole, S. W. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004601 · Cited by 415 · see citing works
Self-citationYang, E. V., Sood, A. K., Chen, M., Li, Y., Eubank, T. D., Marsh, C. B., Jewell, S., Flavahan, N. A., Morrison, C., Yeh, P.-E., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2496 · Cited by 407 · see citing works
Self-citationKohm, A. P., & Sanders, V. M. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01510-2 · Cited by 397 · see citing works
Hanoun, M., Zhang, D., Mizoguchi, T., Pinho, S., Pierce, H., Kunisaki, Y., Lacombe, J., Armstrong, S. A., Dührsen, U., & Frenette, P. S. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.06.020 · Cited by 381 · see citing works
Cancer-Related Axonogenesis and Neurogenesis in Prostate Cancer
Ayala, G. E., Dai, H., Powell, M., Li, R., Ding, Y., Wheeler, T. M., Shine, D., Kadmon, D., Thompson, T., Miles, B. J., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1164 · Cited by 380 · see citing works
Cortisol and epinephrine control opposing circadian rhythms in T cell subsets
Dimitrov, S., Benedict, C., Heutling, D., Westermann, J., Born, J., & Lange, T. (2009) · Blood · doi:10.1182/blood-2008-11-190769 · Cited by 368 · see citing works
Cao, L., Liu, X., Lin, E.-J. D., Wang, C., Choi, E., Riban, V., Lin, B., & During, M. J. (2010) · Cell · doi:10.1016/j.cell.2010.05.029 · Cited by 368 · see citing works
Kohm, A. P., & Sanders, V. M. (2001) · PubMed · Cited by 357 · see citing works
Sterling, P. (2004) · Allostasis, Homeostasis, and the Costs of Physiological Adaptation · doi:10.1017/cbo9781316257081.004 · Cited by 353 · see citing works
Yang, E. V., Kim, S.-J., Donovan, E. L., Chen, M., Gross, A. C., Marketon, J. I. W., Barsky, S. H., & Glaser, R. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.10.005 · Cited by 320 · see citing works
Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration
Lucas, D., Scheiermann, C., Chow, A. T., Kunisaki, Y., Bruns, I., Barrick, C. A., Tessarollo, L., & Frenette, P. S. (2013) · Nature Medicine · doi:10.1038/nm.3155 · Cited by 300 · see citing works
Palm, D., Lang, K., Niggemann, B., Drell, T. L., Masur, K., Zaenker, K. S., & Entschladen, F. (2005) · International Journal of Cancer · doi:10.1002/ijc.21723 · Cited by 298 · see citing works
Control of lymphocyte egress from lymph nodes through β2-adrenergic receptors
Nakai, A., Hayano, Y., Furuta, F., Noda, M., & Suzuki, K. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20141132 · Cited by 290 · see citing works
Kim-Fuchs, C., Le, C. P., Pimentel, M. A., Shackleford, D., Ferrari, D., Angst, E., Hollande, F., & Sloan, E. K. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.02.019 · Cited by 287 · see citing works
Perturbing the organism: the biology of stressful experience
(1993) · Choice Reviews Online · doi:10.5860/choice.30-2669 · Cited by 285 · see citing works
Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis
Sood, A. K., Armaiz-Pena, G. N., Halder, J., Nick, A. M., Stone, R. L., Hu, W., Carroll, A. R., Spannuth, W. A., Deavers, M. T., Allen, J. K., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40802 · Cited by 283 · see citing works
Self-citationDrell, T. L., Joseph, J., Lang, K. S., Niggemann, B., Zaenker, K. S., & Entschladen, F. (2003) · Breast Cancer Research and Treatment · doi:10.1023/a:1024491219366 · Cited by 277 · see citing works
Neural Regulation of Hematopoiesis, Inflammation, and Cancer
Hanoun, M., Maryanovich, M., Arnal-Estapé, A., & Frenette, P. S. (2015) · Neuron · doi:10.1016/j.neuron.2015.01.026 · Cited by 265 · see citing works
Improving Postoperative Immune Status and Resistance to Cancer Metastasis
Goldfarb, Y., Sorski, L., Benish, M., Levi, B. Z., Melamed, R., & Ben‐Eliyahu, S. (2011) · Annals of Surgery · doi:10.1097/sla.0b013e318211d7b5 · Cited by 262 · see citing works
Allostasis, Homeostasis, and the Costs of Physiological Adaptation
(2004) · Cambridge University Press eBooks · doi:10.1017/cbo9781316257081 · Cited by 261 · see citing works
Computational identification of gene–social environment interaction at the human <i>IL6</i> locus
Cole, S. W., Arevalo, J. M. G., Takahashi, R., Sloan, E. K., Lutgendorf, S. K., Sood, A. K., Sheridan, J. F., & Seeman, T. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911515107 · Cited by 256 · see citing works
Self-citationLang, K., Drell, T. L., Lindecke, A., Niggemann, B., Kaltschmidt, C., Zaenker, K. S., & Entschladen, F. (2004) · International Journal of Cancer · doi:10.1002/ijc.20410 · Cited by 256 · see citing works
Grytli, H. H., Fagerland, M. W., Fosså, S. D., & Taskén, K. A. (2013) · European Urology · doi:10.1016/j.eururo.2013.01.007 · Cited by 254 · see citing works
Why zebras don't get ulcers : a guide to stress, stress related diseases, and coping
Sapolsky, R. M. (1994) · W.H. Freeman eBooks · Cited by 252 · see citing works
Social isolation is associated with elevated tumor norepinephrine in ovarian carcinoma patients
Lutgendorf, S. K., DeGeest, K., Dahmoush, L., Farley, D. B., Penedo, F. J., Bender, D., Goodheart, M. J., Buekers, T., Méndez, L., Krueger, G., et al. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.10.012 · Cited by 242 · see citing works
Self-citationGlasner, A., Avraham, R., Rosenne, E., Benish, M., Zmora, O., Shemer, S., Meiboom, H., & Ben‐Eliyahu, S. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903301 · Cited by 239 · see citing works
Pasquier, E., Ciccolini, J., Carre, M., Giacometti, S., Fanciullino, R., Pouchy, C., Montero, M.-P., Serdjebi, C., Kavallaris, M., & André, N. (2011) · Oncotarget · doi:10.18632/oncotarget.343 · Cited by 234 · see citing works
Behavioral stress accelerates prostate cancer development in mice
Hassan, S., Karpova, Y., Baiz, D., Yancey, D., Pullikuth, A., Flores, A., Register, T. C., Cline, J. M., D’Agostino, R., Danial, N. N., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci63324 · Cited by 231 · see citing works
Cole, S. W., Korin, Y. D., Fahey, J. L., & Zack, J. A. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.2.610 · Cited by 228 · see citing works
Self-citationSocial regulation of human gene expression: mechanisms and implications for public health
Cole, S. W. (2013) · American Journal of Public Health · doi:10.2105/ajph.2012.301183 · Cited by 225 · see citing works
Self-citationSastry, K. S., Karpova, Y., Prokopovich, S., Smith, A. J., Essau, B., Gersappe, A., Carson, J. P., Weber, M. J., Register, T. C., Chen, Y. Q., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611370200 · Cited by 225 · see citing works
Dar, A., Schajnovitz, A., Lapid, K., Kalinkovich, A., Itkin, T., Ludin, A., Kao, W.-M., Battista, M., Tesio, M., Kollet, Ó., et al. (2011) · Leukemia · doi:10.1038/leu.2011.62 · Cited by 220 · see citing works
Depression, social support, and beta-adrenergic transcription control in human ovarian cancer
Lutgendorf, S. K., DeGeest, K., Sung, C. Y., Arevalo, J. M., Penedo, F., Lucci, J., Goodheart, M., Lubaroff, D., Farley, D. M., Sood, A. K., et al. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.04.155 · Cited by 215 · see citing works
Self-citationSurgical Stress Promotes Tumor Growth in Ovarian Carcinoma
Lee, J., Shahzad, M. M. K., Lin, Y. G., Armaiz-Peña, G. N., Mangala, L. S., Han, H., Kim, H., Nam, E. J., Jennings, N. B., Halder, J., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2966 · Cited by 213 · see citing works
Self-citationSrc activation by β-adrenoreceptors is a key switch for tumour metastasis
Armaiz-Pena, G. N., Allen, J. K., Cruz, A., Stone, R. L., Nick, A. M., Lin, Y. G., Han, L. Y., Mangala, L. S., Villares, G. J., Vivas-Mejia, P., et al. (2013) · Nature Communications · doi:10.1038/ncomms2413 · Cited by 212 · see citing works
Self-citationLemeshow, S. A., Sørensen, H. T., Phillips, G. S., Yang, E. V., Antonsen, S., Riis, A. H., Lesinski, G. B., Jackson, R., & Glaser, R. (2011) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-11-0249 · Cited by 208 · see citing works
Campbell, J. P., Karolak, M. R., Ma, Y., Perrien, D. S., Masood-Campbell, S. K., Penner, N. L., Munoz, S. A., Zijlstra, A., Yang, X., Sterling, J. A. R., et al. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001363 · Cited by 203 · see citing works
Wang, H. M., Liao, Z. X., Komaki, R. U., Welsh, J. W., OʼReilly, M., Chang, J. Y., Zhuang, Y., Levy, L. B., Lu, C., & Gomez, D. R. (2013) · Annals of Oncology · doi:10.1093/annonc/mds616 · Cited by 202 · see citing works
Watkins, J. L., Thaker, P. H., Nick, A. M., Ramondetta, L. M., Kumar, S., Urbauer, D. L., Matsuo, K., Squires, K. C., Coleman, R. L., Lutgendorf, S. K., et al. (2015) · Cancer · doi:10.1002/cncr.29392 · Cited by 198 · see citing works
Self-citationCooperation of β 2 ‐ and β 3 ‐adrenergic receptors in hematopoietic progenitor cell mobilization
Méndez‐Ferrer, S., Battista, M., & Frenette, P. S. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05390.x · Cited by 194 · see citing works
Stress Effects on FosB- and Interleukin-8 (IL8)-driven Ovarian Cancer Growth and Metastasis
Shahzad, M. M. K., Arevalo, J. M. G., Armaiz-Peña, G. N., Lu, C., Stone, R. L., Moreno‐Smith, M., Nishimura, M., Lee, J., Jennings, N. B., Bottsford-Miller, J. N., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.109579 · Cited by 189 · see citing works
Self-citationCatecholamines Regulate Tumor Angiogenesis
Chakroborty, D., Sarkar, C., Basu, B., Dasgupta, P., & Basu, S. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4289 · Cited by 180 · see citing works
Sloan, E. K., Capitanio, J. P., Tarara, R. P., Mendoza, S. P., Mason, W. A., & Cole, S. W. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1247-07.2007 · Cited by 170 · see citing works
Self-citationHuman Physiology From Cells to Systems
Sophie, W. (2016) · Cited by 170 · see citing works
Treatment With β-Blockers and Reduced Disease Progression in Patients With Thick Melanoma
GIORGI, V. D., Grazzini, M., Gandini, S., Benemei, S., Lotti, T., Marchionni, N., & Geppetti, P. (2011) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.131 · Cited by 167 · see citing works
Infections Causing Human Cancer
Hausen, H. Z. (2006) · Wiley eBooks · doi:10.1002/3527609318 · Cited by 164 · see citing works
Pasquier, E., Street, J. A., Pouchy, C., Carre, M., Gifford, A. J., Murray, J. E., Norris, M. D., Trahair, T. N., André, N., & Kavallaris, M. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.205 · Cited by 161 · see citing works
Nilsson, M. B., Armaiz-Peña, G. N., Takahashi, R., Lin, Y. G., Trevino, J. G., Li, Y., Jennings, N., Arevalo, J. M. G., Lutgendorf, S. K., Gallick, G. E., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611539200 · Cited by 158 · see citing works
Self-citationEng, J. W. ‐., Reed, C. B., Kokolus, K. M., Pitoniak, R., Utley, A. T., Bucsek, M. J., Ma, W. W., Repasky, E. A., & Hylander, B. L. (2015) · Nature Communications · doi:10.1038/ncomms7426 · Cited by 157 · see citing works
Madden, K. S., Szpunar, M. J., & Brown, E. B. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1348-y · Cited by 156 · see citing works
Impact of beta blockers on epithelial ovarian cancer survival
Diaz, E. S., Karlan, B. Y., & Li, A. J. (2012) · Gynecologic Oncology · doi:10.1016/j.ygyno.2012.07.102 · Cited by 151 · see citing works
Neuroendocrine influences on cancer progression
Armaiz-Pena, G. N., Cole, S. W., Lutgendorf, S. K., & Sood, A. K. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.06.005 · Cited by 145 · see citing works
Self-citationNeuroendocrine modulation of signal transducer and activator of transcription-3 in ovarian cancer
Landen, C. N., Lin, Y. G., Armaiz Pena, G. N., Das, P. D., Arevalo, J. M., Kamat, A. A., Han, L. Y., Jennings, N. B., Spannuth, W. A., Thaker, P. H., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0858 · Cited by 144 · see citing works
Self-citationGrytli, H. H., Fagerland, M. W., Fosså, S. D., Taskén, K. A., & Håheim, L. L. (2012) · The Prostate · doi:10.1002/pros.22564 · Cited by 144 · see citing works
Chronic stress enhances progression of acute lymphoblastic leukemia via β-adrenergic signaling
Lamkin, D. M., Sloan, E. K., Patel, A. J., Chiang, B. S., Pimentel, M. A., Ma, J. C. Y., Arevalo, J. M. G., Morizono, K., & Cole, S. W. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.01.013 · Cited by 136 · see citing works
Self-citationTherapeutic effect of β-blockers in triple-negative breast cancer postmenopausal women
Botteri, E., Munzone, E., Rotmensz, N., Cipolla, C. M., GIORGI, V. D., Santillo, B., Zanelotti, A., Adamoli, L., Colleoni, M. A., Viale, G., et al. (2013) · Breast Cancer Research and Treatment · doi:10.1007/s10549-013-2654-3 · Cited by 130 · see citing works
The β2-adrenergic receptor and Her2 comprise a positive feedback loop in human breast cancer cells
Shi, M., Liu, D., Duan, H., Lu, Q., Wang, L., Niu, L., Zhang, H., Yong, Z., Gong, Z., Song, L., et al. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-0822-2 · Cited by 127 · see citing works
Inbar, S., Neeman, E., Avraham, R., Benish, M., Rosenne, E., & Ben‐Eliyahu, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019246 · Cited by 121 · see citing works
Moretti, S., Massi, D., Farini, V., Baroni, G., Parri, M., Innocenti, S., Cecchi, R., & Chiarugi, P. (2013) · Laboratory Investigation · doi:10.1038/labinvest.2012.175 · Cited by 117 · see citing works
Guo, K., Ma, Q., Li, J., Wang, Z., Shan, T., Li, W., Xu, Q., & Xie, K. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-0809 · Cited by 117 · see citing works
Neeman, E., Zmora, O., & Ben‐Eliyahu, S. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-1087 · Cited by 113 · see citing works
Calvani, M., Pelon, F., Comito, G., Taddei, M. L., Moretti, S., Innocenti, S., Nassini, R., Gerlini, G., Borgognoni, L., Bambi, F., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2652 · Cited by 107 · see citing works
Time kinetics of the endocrine response to acute psychological stress
Richter, S., Schürmeyer, T. H., Schedlowski, M., Hädicke, A., Tewes, U., Schmidt, R. E., & Wagner, T. O. F. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.5.8626864 · Cited by 107 · see citing works
Beta-adrenergic modulation of NNK-induced lung carcinogenesis in hamsters
Schuller, H. M., Porter, B., & Riechert, A. (2000) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/pl00008474 · Cited by 106 · see citing works
Armaiz-Peña, G. N., González-Villasana, V., Nagaraja, A. S., Rodriguez‐Aguayo, C., Sadaoui, N. C., Stone, R. L., Matsuo, K., Dalton, H. J., Previs, R. A., Jennings, N. B., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2887 · Cited by 105 · see citing works
Self-citationSzpunar, M. J., Burke, K. A., Dawes, R. P., Brown, E. B., & Madden, K. S. (2013) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0079 · Cited by 98 · see citing works
Functional involvement of β3-adrenergic receptors in melanoma growth and vascularization
Monte, M. D., Casini, G., Filippi, L., Nicchia, G. P., Svelto, M., & Bagnoli, P. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1073-6 · Cited by 93 · see citing works
Reeder, A., Attar, M. A., Nazario, L. A., Bathula, C. S., Zhang, A., Hochbaum, D., Roy, E., Cooper, K. L., Oesterreich, S., Davidson, N. E., et al. (2015) · British Journal of Cancer · doi:10.1038/bjc.2015.133 · Cited by 93 · see citing works
Psychosocial Stress Augments Tumor Development through β‐Adrenergic Activation in Mice
Hasegawa, H., & Saiki, I. (2002) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.2002.tb01313.x · Cited by 92 · see citing works
Xu, Q., Wang, Z., Chen, X., Duan, W., Lei, J., Zong, L., Li, X., Sheng, L., Ma, J., Han, L., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.3069 · Cited by 87 · see citing works
Hara, M. R., Sachs, B. D., Caron, M. G., & Lefkowitz, R. J. (2013) · Cell Cycle · doi:10.4161/cc.23368 · Cited by 85 · see citing works
Beta-adrenergic and arachidonic acid-mediated growth regulation of human breast cancer cell lines
Cakir, Y., Plummer, H., Tithof, P. K., & Schuller, H. (2002) · International Journal of Oncology · doi:10.3892/ijo.21.1.153 · Cited by 83 · see citing works
Schofl, C., Becker, C., Prank, K., von zur Muhlen, A., & Brabant, G. (1997) · European Journal of Endocrinology · doi:10.1530/eje.0.1370675 · Cited by 83 · see citing works
Using β-blockers to inhibit breast cancer progression
Powe, D. G., & Entschladen, F. (2011) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2011.123 · Cited by 82 · see citing works
Wingenfeld, K., Whooley, M. A., Neylan, T. C., Otte, C., & Cohen, B. E. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.10.023 · Cited by 81 · see citing works
Anti-tumor activity of the beta-adrenergic receptor antagonist propranolol in neuroblastoma
Wolter, J. K., Wolter, N. E., Blanch, A., Partridge, T., Cheng, L. S., Morgenstern, D. A., Podkowa, M., Kaplan, D. R., & Irwin, M. S. (2013) · Oncotarget · doi:10.18632/oncotarget.1083 · Cited by 79 · see citing works
Effect of β-Blockers and Other Antihypertensive Drugs On the Risk of Melanoma Recurrence and Death
GIORGI, V. D., Gandini, S., Grazzini, M., Benemei, S., Marchionni, N., & Geppetti, P. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.09.001 · Cited by 75 · see citing works
Collado-Hidalgo, A., Sung, C., & Cole, S. (2006) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2006.01.005 · Cited by 69 · see citing works
Self-citationα2-Adrenergic blockade mimics the enhancing effect of chronic stress on breast cancer progression
Lamkin, D. M., Sung, H. Y., Yang, G. S., David, J., Ma, J. C. Y., Cole, S. W., & Sloan, E. K. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.10.004 · Cited by 67 · see citing works
Self-citationImpact of beta-blockers on prostate cancer mortality: a meta-analysis of 16,825 patients
Lu, H., Liu, X., Guo, F., Tan, S., Wang, G., Liu, H., Wang, J., He, X., Mo, Y., & Shi, B. (2015) · OncoTargets and Therapy · doi:10.2147/ott.s78836 · Cited by 67 · see citing works
Stress-induced remodeling of lymphoid innervation
Sloan, E. K., Capitanio, J. P., & Cole, S. W. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.06.011 · Cited by 62 · see citing works
Self-citationWhat Is the Brain-Cancer Connection?
Cao, L., & During, M. J. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150546 · Cited by 62 · see citing works
Flint, M. S., Baum, A. E., Episcopo, B., Knickelbein, K. Z., Dougall, A. L., Chambers, W. H., & Jenkins, F. J. (2012) · Stress · doi:10.3109/10253890.2012.686075 · Cited by 61 · see citing works
The effect of chronic stress on anti-angiogenesis of sunitinib in colorectal cancer models
Liu, J., Deng, G.-H., Zhang, J., Wang, Y., Xia, X.-Y., Luo, X., Deng, Y., He, S., Mao, Y., Peng, X., et al. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.11.008 · Cited by 60 · see citing works
Effect of Chronic Restraint Stress on Human Colorectal Carcinoma Growth in Mice
Lin, Q., Wang, F., Yang, R., Zheng, X., Gao, H.-B., & Zhang, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061435 · Cited by 59 · see citing works
Shan, T., Ma, Q., Zhang, D., Guo, K., Liu, H., Wang, F., & Wu, E. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.04.055 · Cited by 57 · see citing works
Chang, M., Brown, H. J., Collado-Hidalgo, A., Arevalo, J. M. G., Galić, Z., Symensma, T. L., Tanaka, L., Deng, H., Zack, J. A., Sun, R., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.21.13538-13547.2005 · Cited by 56 · see citing works
Self-citationHori, Y., Ishii, K., Kanda, H., Iwamoto, Y., Nishikawa, K., Soga, N., Kise, H., Arima, K., & Sugimura, Y. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-10-0189 · Cited by 53 · see citing works
Protein Kinase A Activation Confers Resistance to Trastuzumab in Human Breast Cancer Cell Lines
Gu, L., Lau, S. K., Loera, S., Somlo, G., & Kane, S. E. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0585 · Cited by 53 · see citing works
Aydıner, A., Çiftçi, R., Karabulut, S., & Kılıç, L. (2013) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2013.14.10.6109 · Cited by 48 · see citing works
Bruzzone, A., Piñero, C. P., Rojas, P. A., Romanato, M., Gass, H., Lanari, C., & Lüthy, I. A. (2011) · Current Cancer Drug Targets · doi:10.2174/156800911796191051 · Cited by 46 · see citing works
Social temperament and lymph node innervation
Sloan, E. K., Capitanio, J. P., Tarara, R. P., & Cole, S. W. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.10.010 · Cited by 44 · see citing works
Self-citationThe role of adrenergic signaling in breast cancer biology
Obeid, E. I., & Conzen, S. D. (2013) · Cancer Biomarkers · doi:10.3233/cbm-130347 · Cited by 42 · see citing works
Exogenous norepinephrine attenuates the efficacy of sunitinib in a mouse cancer model
Deng, G.-H., Liu, J., Zhang, J., Wang, Y., Peng, X., Wei, Y.-Q., & Jiang, Y. (2014) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-33-21 · Cited by 42 · see citing works
Nervous system regulation of the cancer genome
Cole, S. W. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.11.008 · Cited by 41 · see citing works
Self-citationStress-related hormone norepinephrine induces interleukin-6 expression in GES-1 cells
Yang, R., Lin, Q., Gao, H., & Zhang, P. (2014) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20133346 · Cited by 40 · see citing works
Norepinephrine antagonists and cancer risk
FRIEDMAN, G. D., Udaltsova, N. V., & Habel, L. A. (2010) · International Journal of Cancer · doi:10.1002/ijc.25351 · Cited by 30 · see citing works
Expanding Our Therapeutic Options: Beta Blockers for Breast Cancer?
Ganz, P. A., & Cole, S. W. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.35.8820 · Cited by 30 · see citing works
Self-citationMagnon, C., Lucas, D., & Frenette, P. S. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-145-1_1 · Cited by 27 · see citing works
Tumor interactions with soluble factors and the nervous system
Voss, M. J., & Entschladen, F. (2010) · Cell Communication and Signaling · doi:10.1186/1478-811x-8-21 · Cited by 25 · see citing works
Infections Causing Human Cancer
Stein, R. A. (2008) · JAMA · doi:10.1001/jama.299.7.837 · Cited by 24 · see citing works
Boucek, R. J., Kirsh, A. L., Majesky, M. W., & Perkins, J. A. (2013) · Otolaryngology · doi:10.1177/0194599813503445 · Cited by 15 · see citing works
堀, 靖. (2011) · Institutional Repositories DataBase (IRDB) · Cited by 12 · see citing works
Gastric cancer gets a red carpet treatment
Villanueva, M. T. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3825 · Cited by 8 · see citing works
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The updated landscape of tumor microenvironment and drug repurposing
Jin, M.-Z., & Jin, W.-L. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00280-x · Cited by 1,262 · see citing works
Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa
Dantzer, R. (2018) · Physiological Reviews · doi:10.1152/physrev.00039.2016 · Cited by 1,073 · see citing works
Mechanisms and Therapeutic Relevance of Neuro-immune Communication
Chavan, S. S., Pavlov, V. A., & Tracey, K. J. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.008 · Cited by 661 · see citing works
An energetic view of stress: Focus on mitochondria
Picard, M. A., McEwen, B. S., Epel, E. S., & Sandi, C. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.01.001 · Cited by 565 · see citing works
Adrenergic nerves activate an angio-metabolic switch in prostate cancer
Zahalka, A. H., Arnal-Estapé, A., Maryanovich, M., Nakahara, F., Cruz, C. D., Finley, L. W. S., & Frenette, P. S. (2017) · Science · doi:10.1126/science.aah5072 · Cited by 548 · see citing works
Loneliness, Social Isolation, and Cardiovascular Health
Xia, N., & Li, H. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7312 · Cited by 508 · see citing works
Zahalka, A. H., & Frenette, P. S. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0237-2 · Cited by 470 · see citing works
Chronic Stress Promotes Cancer Development
Dai, S., Mo, Y., Wang, Y., Xiang, B., Liao, Q., Zhou, M., Li, X., Li, Y., Xiong, W., Li, G., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01492 · Cited by 405 · see citing works
“Catecholamines can regulate the tumor microenvironment (30).”
Stress and cancer: mechanisms, significance and future directions
Eckerling, A., Ricon-Becker, I., Sorski, L., Sandbank, E., & Ben-Eliyahu, S. (2021) · Nature Reviews Cancer · doi:10.1038/s41568-021-00395-5 · Cited by 348 · see citing works
Psychological Stress and Mitochondria: A Systematic Review
Picard, M. A., & McEwen, B. S. (2018) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000545 · Cited by 339 · see citing works
Adrover, J. M., McDowell, S. A. C., He, X., Quail, D. F., & Egeblad, M. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.001 · Cited by 349 · see citing works
Mohammadpour, H., MacDonald, C. R., Qiao, G., Chen, M., Dong, B., Hylander, B. L., McCarthy, P. L., Abrams, S. I., & Repasky, E. A. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129502 · Cited by 328 · see citing works
Mechanisms of cancer dissemination along nerves
Amit, M., Na’ara, S., & Gil, Z. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.38 · Cited by 314 · see citing works
Bucsek, M. J., Qiao, G., MacDonald, C. R., Giridharan, T., Evans, L., Niedzwecki, B., Liu, H., Kokolus, K. M., Eng, J. W.-L., Messmer, M. N., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0546 · Cited by 294 · see citing works
Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies
Cervantes‐Villagrana, R. D., Albores‐García, D., Cervantes-Villagrana, A. R., & García-Acevez, S. J. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0205-z · Cited by 299 · see citing works
Nerve Dependence: From Regeneration to Cancer
Boilly, B., Faulkner, S., Jobling, P., & Hondermarck, H. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.02.005 · Cited by 295 · see citing works
Kamiya, A., Hayama, Y., Kato, S., Shimomura, A., Shimomura, T., Irie, K., Kaneko, R., Yanagawa, Y., Kobayashi, K., & Ochiya, T. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0430-3 · Cited by 285 · see citing works
RetractedSurgical stress and cancer progression: the twisted tango
Chen, Z., Zhang, P., Xu, Y., Yan, J., Liu, Z., Lau, W. B., Lau, B., Li, Y., Zhao, X., Wei, Y., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1058-3 · Cited by 223 · see citing works
Wall, T., Sherwin, A., Ma, D., & Buggy, D. J. (2019) · British Journal of Anaesthesia · doi:10.1016/j.bja.2019.04.062 · Cited by 215 · see citing works
The immune microenvironment in gastric adenocarcinoma
Zavros, Y. L., & Merchant, J. L. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00591-0 · Cited by 198 · see citing works
Critical Neurotransmitters in the Neuroimmune Network
Hodo, T., de Aquino, M. T. P., Shimamoto, A., & Shanker, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01869 · Cited by 187 · see citing works
de Boer, R. A., Hulot, J., Tocchetti, C. G., Aboumsallem, J. P., Ameri, P., Anker, S. D., Bauersachs, J. K., Bertero, E., Coats, A. J. S., Čelutkienė, J., et al. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.2029 · Cited by 186 · see citing works
Linking Heart Failure to Cancer
Bertero, E., Canepa, M., Maack, C., & Ameri, P. (2018) · Circulation · doi:10.1161/circulationaha.118.033603 · Cited by 182 · see citing works
Modulation of anti-tumor immunity by the brain’s reward system
Ben-Shaanan, T. L., Schiller, M., Azulay‐Debby, H., Korin, B., Boshnak, N., Koren, T., Krot, M., Shakya, J., Rahat, M. A., Hakim, F., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05283-5 · Cited by 174 · see citing works
Adrenergic Signaling: A Targetable Checkpoint Limiting Development of the Antitumor Immune Response
Qiao, G., Chen, M., Bucsek, M. J., Repasky, E. A., & Hylander, B. L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00164 · Cited by 168 · see citing works
The role of oxidative stress in cardiovascular disease caused by social isolation and loneliness
Li, H., & Xia, N. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101585 · Cited by 159 · see citing works
Dietary Fat and Cancer—Which Is Good, Which Is Bad, and the Body of Evidence
Bojková, B., Winklewski, P. J., & Wszędybył-Winklewska, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114114 · Cited by 158 · see citing works
Fjæstad, K. Y., Rømer, A. M. A., Goitea, V. E., Johansen, A. Z., Thorseth, M., Carretta, M., Engelholm, L. H., Grøntved, L., Junker, N., & Madsen, D. H. (2022) · Oncogene · doi:10.1038/s41388-021-02170-0 · Cited by 157 · see citing works
Social Stress Mobilizes Hematopoietic Stem Cells to Establish Persistent Splenic Myelopoiesis
McKim, D. B., Yin, W., Wang, Y., Cole, S. W., Godbout, J. P., & Sheridan, J. F. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.102 · Cited by 153 · see citing works
Self-citationRyder, A. L., Azcarate, P. M., & Cohen, B. E. (2018) · Current Psychiatry Reports · doi:10.1007/s11920-018-0977-9 · Cited by 155 · see citing works
Zhou, X., Ma, Z., Zhang, L., Zhou, S., Wang, J., Wang, B., & Fu, W. (2016) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2016.08.004 · Cited by 149 · see citing works
How cancer hijacks the body’s homeostasis through the neuroendocrine system
Slominski, R. M., Raman, C., Chen, J. Y., & Slominski, A. T. (2023) · Trends in Neurosciences · doi:10.1016/j.tins.2023.01.003 · Cited by 156 · see citing works
Chen, X., & Song, E. (2022) · 癌症：英文版 · doi:10.1002/cac2.12316 · Cited by 144 · see citing works
Work Stress and the Risk of Cancer: A Meta-Analysis of Observational Studies
Yang, T., Qiao, Y., Xiang, S., Li, W., Gan, Y., & Chen, Y. (2019) · International Journal of Cancer · doi:10.1002/ijc.31955 · Cited by 145 · see citing works
Chen, H., Liu, D., Guo, L., Cheng, X., Guo, N., & Shi, M. (2017) · The Journal of Pathology · doi:10.1002/path.4988 · Cited by 143 · see citing works
Neurons generated from carcinoma stem cells support cancer progression
Lu, R., Fan, C., Shangguan, W., Liu, Y., Li, Y., Shang, Y., Yin, D., Zhang, S., Huang, Q., Li, X., et al. (2017) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2016.36 · Cited by 132 · see citing works
Obesity, Dietary Factors, Nutrition, and Breast Cancer Risk
Seiler, A., Chen, M. A., Brown, R. L., & Fagundes, C. P. (2018) · Current Breast Cancer Reports · doi:10.1007/s12609-018-0264-0 · Cited by 131 · see citing works
Antoni, M. H., Moreno, P. I., & Penedo, F. J. (2023) · Annual Review of Psychology · doi:10.1146/annurev-psych-030122-124119 · Cited by 132 · see citing works
Nerves in the Tumor Microenvironment: Origin and Effects
Wang, W., Li, L., Chen, N., Niu, C. S., Li, Z., Hu, J., & Cui, J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.601738 · Cited by 126 · see citing works
Beyond the tumour microenvironment
Laplane, L., Duluc, D., Bikfalvi, A., Larmonier, N., & Pradeu, T. (2019) · International Journal of Cancer · doi:10.1002/ijc.32343 · Cited by 123 · see citing works
The embodied mind: A review on functional genomic and neurological correlates of mind-body therapies
Muehsam, D. J., Lutgendorf, S. K., Mills, P. J., Rickhi, B., Chevalier, G., Bat, N., Chopra, D., & Gurfein, B. T. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.027 · Cited by 123 · see citing works
Self-citationHunyor, I., & Cook, K. M. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00036.2018 · Cited by 121 · see citing works
Haldar, R., Ricon‐Becker, I., Radin, A., Gutman, M., Cole, S. W., Zmora, O., & Ben‐Eliyahu, S. (2020) · Cancer · doi:10.1002/cncr.32950 · Cited by 122 · see citing works
Self-citationThe role of nerve fibers and their neurotransmitters in regulating intervertebral disc degeneration
Sun, K., Jiang, J., Wang, Y., Sun, X., Zhu, J., Xu, X., Sun, J., & Shi, J. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101733 · Cited by 119 · see citing works
Repurposing Drugs in Oncology (ReDO)—Propranolol as an anti-cancer agent
Pantziarka, P., Bouche, G., Sukhatme, V. V., Meheus, L., Rooman, I., & Sukhatme, V. P. (2016) · ecancermedicalscience · doi:10.3332/ecancer.2016.680 · Cited by 117 · see citing works
An overview of cancer health disparities: new approaches and insights and why they matter
Minas, T. Z., Bailey‐Whyte, M., Ajao, A., & Ambs, S. (2020) · Carcinogenesis · doi:10.1093/carcin/bgaa121 · Cited by 117 · see citing works
Kohrt, B. A., Worthman, C. M., Adhikari, R. P., Luitel, N. P., Arevalo, J. M. G., Ma, J., McCreath, H., Seeman, T. E., Crimmins, E. M., & Cole, S. W. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1601301113 · Cited by 110 · see citing works
Self-citationBlockade of β-Adrenergic Receptors Improves CD8+ T-cell Priming and Cancer Vaccine Efficacy
Daher, C., Vimeux, L., Stoeva, R., Peranzoni, E., Bismuth, G., Wieduwild, É., Lucas, B., Donnadieu, E., Bercovici, N., Trautmann, A., et al. (2019) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0833 · Cited by 108 · see citing works
Thermoneutrality, mice, and cancer: a heated opinion
Hylander, B. L., & Repasky, E. A. (2016) · Trends in cancer · doi:10.1016/j.trecan.2016.03.005 · Cited by 107 · see citing works
Sympathetic and parasympathetic innervation in cancer: therapeutic implications
Kamiya, A., Hiyama, T. Y., Fujimura, A., & Yoshikawa, S. (2020) · Clinical Autonomic Research · doi:10.1007/s10286-020-00724-y · Cited by 113 · see citing works
Perineural invasion in colorectal cancer: mechanisms of action and clinical relevance
Wang, H., Huo, R., He, K., Li, C., Zhang, S., Yu, M., Zhao, W., Li, H., & Xue, J. (2023) · Cellular Oncology · doi:10.1007/s13402-023-00857-y · Cited by 114 · see citing works
Seiler, A., von Känel, R., & Slavich, G. M. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.565239 · Cited by 110 · see citing works
Can Stopping Nerves, Stop Cancer?
Saloman, J. L., Albers, K. M., Rhim, A. D., & Davis, B. M. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.10.002 · Cited by 105 · see citing works
Melanoma-Induced Reprogramming of Schwann Cell Signaling Aids Tumor Growth
Shurin, G. V., Kruglov, O., Ding, F., Lin, Y., Hao, X., Keskinov, A. A., You, Z., Lokshin, A. E., LaFramboise, W. A., Falo, L. D., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3872 · Cited by 105 · see citing works
Harnessing cancer immunotherapy during the unexploited immediate perioperative period
Matzner, P., Sandbank, E., Neeman, E., Zmora, O., Gottumukkala, V. N. R., & Ben‐Eliyahu, S. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0319-9 · Cited by 103 · see citing works
Differentiation and transdifferentiation potentials of cancer stem cells
Huang, Z.-J., Wu, T., Liu, A. Y., & Ouyang, G. (2015) · OncoTarget · doi:10.18632/oncotarget.6098 · Cited by 92 · see citing works
Catecholamines contribute to the neovascularization of lung cancer via tumor-associated macrophages
Xia, Y., Wei, Y., Li, Z.-Y., Cai, X.-Y., Zhang, L.-L., Dong, X.-R., Zhang, S., Zhang, R.-G., Meng, R., Zhu, F., et al. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.06.004 · Cited by 103 · see citing works
β-Adrenergic modulation of cancer cell proliferation: available evidence and clinical perspectives
Coelho, M., Soares-Silva, C., Abreu, D. B., Marino, F., Cosentino, M., & Ribeiro, L. V. P. T. (2016) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-016-2278-1 · Cited by 96 · see citing works
Chen, M., Qiao, G., Hylander, B. L., Mohammadpour, H., Wang, X., Subjeck, J. R., Singh, A. K., & Repasky, E. A. (2020) · Nature Communications · doi:10.1038/s41467-020-15676-0 · Cited by 95 · see citing works
Chronic Stress Effects on Tumor: Pathway and Mechanism
Hong, H., Ji, M. J., & Lai, D. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.738252 · Cited by 95 · see citing works
β-Adrenergic-stimulated macrophages: Comprehensive localization in the M1-M2 spectrum
Lamkin, D. M., Ho, H.-Y., Ong, T. H., Kawanishi, C. K., Stoffers, V. L., Ahlawat, N., Ma, J. C. Y., Arevalo, J. M. G., Cole, S. W., & Sloan, E. K. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.07.162 · Cited by 94 · see citing works
Self-citationSzpunar, M. J., Belcher, E. K., Dawes, R. P., & Madden, K. S. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.12.014 · Cited by 92 · see citing works
Cancer Incidence and Mortality According to Pre-Existing Heart Failure in a Community-Based Cohort
Bertero, E., Robusto, F., Rulli, E., D'Ettorre, A., Bisceglia, L., Staszewsky, L. I., Maack, C., Lepore, V. L., Latini, R., & Ameri, P. (2022) · JACC CardioOncology · doi:10.1016/j.jaccao.2021.11.007 · Cited by 91 · see citing works
Stress and coping in women with breast cancer:unravelling the mechanisms to improve resilience
Borgi, M., Collacchi, B., Ortona, E., & Cirulli, F. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.10.011 · Cited by 90 · see citing works
Antoni, M. H., Bouchard, L. C., Jacobs, J. M., Lechner, S. C., Jutagir, D. R., Gudenkauf, L. M., Carver, C. S., Lutgendorf, S., Cole, S. W., Lippman, M., et al. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.09.012 · Cited by 89 · see citing works
Self-citationHow Comorbidities Shape Cancer Biology and Survival
Panigrahi, G., & Ambs, S. (2021) · Trends in cancer · doi:10.1016/j.trecan.2020.12.010 · Cited by 88 · see citing works
Haldar, R., Shaashua, L., Lavon, H., Lyons, Y. A., Zmora, O., Sharon, E., Birnbaum, Y., Allweis, T. M., Sood, A. K., Barshack, I., et al. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.05.014 · Cited by 88 · see citing works
Self-citationSorski, L., Melamed, R., Matzner, P., Lavon, H., Shaashua, L., Rosenne, E., & Ben-Eliyahu, S. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.05.017 · Cited by 85 · see citing works
Barquilla, A., Lamberto, I., Noberini, R., Heynen‐Genel, S., Brill, L. M., & Pasquale, E. B. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-01-0048 · Cited by 82 · see citing works
Zimmaro, L., Sephton, S. E., Siwik, C. J., Phillips, K. M., Rebholz, W., Kraemer, H., Giese-Davis, J., Wilson, L. D., Bumpous, J., & Cash, E. D. (2018) · Cancer · doi:10.1002/cncr.31109 · Cited by 86 · see citing works
Wrobel, L. J., Bod, L., Lengagne, R., Kato, M., Prévost‐Blondel, A., & Gal, F. L. (2016) · Oncotarget · doi:10.18632/oncotarget.12833 · Cited by 83 · see citing works
Targeting tumor innervation: premises, promises, and challenges
Li, X., Peng, X., Yang, S., Wei, S., Fan, Q., Liu, J., Yang, L., & Li, H. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-00930-9 · Cited by 83 · see citing works
Nerve input to tumours: Pathophysiological consequences of a dynamic relationship
Hutchings, C., Phillips, J. A., & Djamgoz, M. B. A. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188411 · Cited by 79 · see citing works
The Behavioral Medicine Research Council: Its origins, mission, and methods.
Freedland, K. E. (2019) · Health Psychology · doi:10.1037/hea0000731 · Cited by 76 · see citing works
Gillis, R. D., Botteri, E., Chang, A., Ziegler, A. I., Chung, N.-C., Pon, C. K., Shackleford, D. M., Andreassen, B. K., Halls, M. L., Baker, J. G., et al. (2021) · European Journal of Cancer · doi:10.1016/j.ejca.2021.01.029 · Cited by 76 · see citing works
Chronic stress in solid tumor development: from mechanisms to interventions
Yan, J., Chen, Y., Luo, M., Hu, X., Li, H., Liu, Q., & Zou, Z. (2023) · Journal of Biomedical Science · doi:10.1186/s12929-023-00903-9 · Cited by 84 · see citing works
Role of stress in the pathogenesis of cancer (Review)
Lempesis, I. G., GEORGAKOPOULOU, V. E., Papalexis, P., Chrousos, G. P., & Spandidos, D. A. (2023) · International Journal of Oncology · doi:10.3892/ijo.2023.5572 · Cited by 80 · see citing works
Liu, C., Yang, Y., Chen, C., Li, L., Li, J., Wang, X., Chu, Q., Qiu, L., Ba, Q., Li, X., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25967-9 · Cited by 74 · see citing works
Kesler, S. R., Adams, M., Packer, M., Rao, V., Henneghan, A. M., Blayney, D. W., & Palesh, O. (2017) · Brain and Behavior · doi:10.1002/brb3.643 · Cited by 77 · see citing works
Adverse childhood experiences (ACEs), cell-mediated immunity, and survival in the context of cancer
Steel, J., Antoni, M., Pathak, R., Butterfield, L., Vodovotz, Y., Savkova, A., Wallis, M., Wang, Y.-S., Jing, H., Grammer, E., et al. (2020) · Brain, behavior, and immunity · doi:10.1016/j.bbi.2020.04.050 · Cited by 26 · see citing works
Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target
Nguyen, T. M., & Lee, C. H. (2020) · Cancers · doi:10.3390/cancers12061600 · Cited by 67 · see citing works
Mravec, B., Tibenský, M., Horváthová, Ľ., & Babál, P. (2019) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-19-0346 · Cited by 70 · see citing works
Epinephrine promotes COX-2-dependent immune suppression in myeloid cells and cancer tissues
Muthuswamy, R., Okada, N. J., Jenkins, F. J., McGuire, K. P., McAuliffe, P. F., Zeh, H. J., Bartlett, D. L., Wallace, C. T., Watkins, S. C., Henning, J. D., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.02.008 · Cited by 69 · see citing works
Brown, L. C., Murphy, A. R., Lalonde, C. S., Subhedar, P. D., Miller, A. H., & Stevens, J. S. (2020) · Cancer · doi:10.1002/cncr.32934 · Cited by 68 · see citing works
Sympathetic activity in breast cancer and metastasis: partners in crime
Conceição, F., Sousa, D. M., Paredes, J., & Lamghari, M. (2021) · Bone Research · doi:10.1038/s41413-021-00137-1 · Cited by 68 · see citing works
The Emerging Role of Nerves and Glia in Colorectal Cancer
Schonkeren, S. L., Thijssen, M. S., Vaes, N., Boesmans, W., & Melotte, V. (2021) · Cancers · doi:10.3390/cancers13010152 · Cited by 68 · see citing works
Ricon, I., Hanalis‐Miller, T., Haldar, R., Jacoby, R., & Ben‐Eliyahu, S. (2019) · Cancer · doi:10.1002/cncr.31594 · Cited by 71 · see citing works
Neighborhood Disadvantage and Breast Cancer–Specific Survival
Goel, N., Hernandez, A. E., Thompson, C., Choi, S., Westrick, A. C., Stoler, J. B., Antoni, M. H., Rojas, K. E., Kesmodel, S. B., Figueroa, M. E., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.8908 · Cited by 67 · see citing works
Self-citationβ 3 ‐Adrenoceptor as a potential immuno‐suppressor agent in melanoma
Calvani, M., Bruno, G., Monte, M. D., Nassini, R., Fontani, F., Casini, A., Cavallini, L., Becatti, M., Bianchini, F., Logu, F. D., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14660 · Cited by 66 · see citing works
Obstructive Sleep Apnea and Incident Cancer: A Large Retrospective Multicenter Clinical Cohort Study
Kendzerska, T., Povitz, M., Leung, R. S. T., Boulos, M. I., McIsaac, D. I., Murray, B. J., Bryson, G. L., Talarico, R., Hilton, J. F., Malhotra, A., et al. (2020) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-20-0975 · Cited by 69 · see citing works
Chronic stress accelerates the development of endometriosis in mouse through adrenergic receptor β2
Long, Q., Liu, X., Qi, Q.-M., & Guo, S. (2016) · Human Reproduction · doi:10.1093/humrep/dew237 · Cited by 67 · see citing works
Jiang, W., Yu, L., Li, Z., Sun, J., Li, J.-W., Wei, W., Li, L., Zhang, C., Huang, C., Yang, S., et al. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.05.031 · Cited by 66 · see citing works
Adrenergic-mediated increases in INHBA drive CAF phenotype and collagens
Nagaraja, A. S., Dood, R. L., Armaiz-Peña, G. N., Kang, Y., Wu, S. Y., Allen, J. K., Jennings, N. B., Mangala, L. S., Pradeep, S., Lyons, Y., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.93076 · Cited by 63 · see citing works
Self-citationStress, inflammation, and eicosanoids: an emerging perspective
Umamaheswaran, S., Dasari, S. K., Yang, P., Lutgendorf, S. K., & Sood, A. K. (2018) · Cancer and Metastasis Reviews · doi:10.1007/s10555-018-9741-1 · Cited by 64 · see citing works
Self-citationThe Neuroimmune Axis in the Tumor Microenvironment
Shurin, M. R., Shurin, G. V., Zlotnikov, S. B., & Bunimovich, Y. L. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1900828 · Cited by 61 · see citing works
Hijacking of the nervous system in cancer: mechanism and therapeutic targets
Zhang, Y., Liao, Q., Wen, X., Fan, J., Yuan, T., Tong, X., Jia, R., Chai, P., & Fan, X. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02246-5 · Cited by 64 · see citing works
Falcinelli, M., Thaker, P. H., Lutgendorf, S. K., Conzen, S. D., Flaherty, R. L., & Flint, M. S. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-0684 · Cited by 65 · see citing works
Self-citationLinks between inflammation, amygdala reactivity, and social support in breast cancer survivors
Muscatell, K. A., Eisenberger, N. I., Dutcher, J. M., Cole, S. W., & Bower, J. E. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.09.008 · Cited by 60 · see citing works
Self-citationLinking Structural Racism and Discrimination and Breast Cancer Outcomes: A Social Genomics Approach
Carlos, R. C., Obeng‐Gyasi, S., Cole, S. W., Zebrack, B. J., Pisano, E. D., Troester, M. A., Timsina, L., Wagner, L. I., Steingrimsson, J. A., Gareen, I. F., et al. (2022) · Journal of Clinical Oncology · doi:10.1200/jco.21.02004 · Cited by 61 · see citing works
Self-citationThe Risk of Psychological Stress on Cancer Recurrence: A Systematic Review
Oh, H.-M., & Son, C. (2021) · Cancers · doi:10.3390/cancers13225816 · Cited by 60 · see citing works
- Authors
- Cole, S. W., Nagaraja, A. S., Lutgendorf, S. K., Green, P. A., & Sood, A. K.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- University of Iowa (US)
- National Cancer Institute (US)
- Venue
- Nature Reviews Cancer
- Published
- 2015-08-24
- Volume
- 15
- Issue
- 9
- Pages
- 563-572
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- PMC
- PMC4828959
- OpenAlex
- W1959055352
- Cited by
- 576
- References
- 132
- Citations by year
- 2026: 66 · 2025: 53 · 2024: 47 · 2023: 63 · 2022: 66 · 2021: 57 · 2020: 67 · 2019: 57 · 2018: 43 · 2017: 32 · 2016: 22 · 2015: 3
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG017265, R37AG033590, AG033590, R01AG033590, P30AG017265)
- National Cancer Institute (CA 109298, CA177909, P50CA098258, U54CA151668, R01CA177909, CA083639, CA-104825, R01CA109298, CA140933, R01CA116778, R01CA104825, CA151668, CA-116778, R01CA140933, P50CA083639, CA098258, P30CA016672)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- sympathetic nervous system, tumor microenvironment, peripheral autonomic nervous system, beta-adrenergic signaling, physiological stress, metastasis, macrophage infiltration, tumor inflammation, angiogenesis, epithelial-mesenchymal transition, tumor invasion, antitumor immunity, hematologic cancer, cancer stem cells, hematopoietic differentiation
- MeSH terms
- Cell Differentiation, Humans, Neoplasms, Neovascularization, Pathologic, Sympathetic Nervous System, Gene Expression Regulation, Neoplastic, Epithelial-Mesenchymal Transition, Tumor Microenvironment
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