The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Calcium regulation of neuronal gene expression
Open accessAbstract
Plasticity is a remarkable feature of the brain, allowing neuronal structure and function to accommodate to patterns of electrical activity. One component of these long-term changes is the activity-driven induction of new gene expression, which is required for both the long-lasting long-term potentiation of synaptic transmission associated with learning and memory, and the activitydependent survival events that help to shape and wire the brain during development. We have characterized molecular mechanisms by which neuronal membrane depolarization and subsequent calcium influx into the cytoplasm lead to the induction of new gene transcription. We have identified three points within this cascade of events where the specificity of genes induced by different types of stimuli can be regulated. By using the induction of the gene that encodes brain-derived neurotrophic factor (BDNF) as a model, we have found that the ability of a calcium influx to induce transcription of this gene is regulated by the route of calcium entry into the cell, by the pattern of phosphorylation induced on the transcription factor cAMP-response element (CRE) binding protein (CREB), and by the complement of active transcription factors recruited to the BDNF promoter. These results refine and expand the working model of activity-induced gene induction in the brain, and help to explain how different types of neuronal stimuli can activate distinct transcriptional responses.
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Cites
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Cited by
Function and regulation of CREB family transcription factors in the nervous system
Lonze, B. E., & Ginty, D. D. (2002) · Neuron · doi:10.1016/s0896-6273(02)00828-0 · Cited by 2,127
HDAC2 negatively regulates memory formation and synaptic plasticity
Guan, J.-S., Haggarty, S. J., Giacometti, E., Dannenberg, J.-H., Joseph, N., Gao, J., Nieland, T. J. F., Zhou, Y., Wang, X., Mazitschek, R., et al. (2009) · Nature · doi:10.1038/nature07925 · Cited by 1,644
DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation
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Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2
Chen, W. G., Chang, Q., Lin, Y., Meissner, A., West, A. E., Griffith, E. C., Jaenisch, R., & Greenberg, M. E. (2003) · Science · doi:10.1126/science.1086446 · Cited by 1,232
Self-citationNew insights into BDNF function in depression and anxiety
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Metadata
- Authors
- West, A. E., Chen, W. G., Dalva, M. B., Dolmetsch, R. E., Kornhauser, J. M., Shaywitz, A. J., Takasu, M. A., Tao, X., & Greenberg, M. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-09-25
- Volume
- 98
- Issue
- 20
- Pages
- 11024-11031
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2058861807
- Cited by
- 1,034
- References
- 14
- FWCI
- 18.91
- Type
- journal article
- Language
- en
- Open access
- bronze
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- West, A. E., Chen, W. G., Dalva, M. B., Dolmetsch, R. E., Kornhauser, J. M., Shaywitz, A. J., Takasu, M. A., Tao, X., & Greenberg, M. E. (2001). Calcium regulation of neuronal gene expression. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.191352298
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