Increased expression of cSHMT, Tbx3 and utrophin in plasma of ovarian and breast cancer patients
Abstract
Plasma samples of ovarian and breast cancer patients were used to search for markers of cancer using 2-dimensional gel electrophoresis and matrix-assisted laser desorption/ionization time of flight mass spectrometry. Truncated forms of cytosolic serine hydroxymethyl transferase (cSHMT), T-box transcription factor 3 (Tbx3) and utrophin were aberrantly expressed in samples from cancer patients as compared to samples from noncancerous cases. Aberrant expression of proteins was validated by immunoblotting of plasma samples with specific antibodies to cSHMT, Tbx3 and utrophin. A cohort of 79 breast and 39 ovarian cancer patients and 31 individuals with noncancerous conditions was studied. We observed increased expression of truncated cSHMT, Tbx3 and utrophin in plasma samples obtained from patients at early stages of disease. Our data suggest that cSHMT, Tbx3 and utrophin can be used as components of multiparameter monitoring of ovarian and breast cancer (supplementary material for this article can be found on the International Journal of Cancer website at http://www.interscience.wiley.com/jpages/0020-7136/suppmat/index.html).
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The importance of TBX3 in relation to proliferation is underpinned by studies of its role in oncogenesis.
“The importance of TBX3 in relation to proliferation is underpinned by studies of its role in oncogenesis [24, 25, 58, 59].”
From The oncoprotein TBX3 is controlling severity in experimental arthritis (2019) · cites this paper as [24]
Cites
Use of proteomic patterns in serum to identify ovarian cancer
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Emerging molecular markers of cancer
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“Overexpression of Tbx3 is not restricted to liver cancer because it has been described in breast and ovarian cancer (30, 48 ) and in ovarian endometrioid adenocarcinomas characterized with respect to mutations affecting the Wnt/hcatenin pathway (49).”
BackgroundThe oncogenic TBX3 is a downstream target and mediator of the TGF-β1 signaling pathway
Li, J., Weinberg, M. S., Zerbini, L., & Prince, S. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-05-0273 · Cited by 56 · see citing works
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The oncoprotein TBX3 is controlling severity in experimental arthritis
Sardar, S., Kerr, A., Vaartjes, D., Moltved, E. R., Karosiene, E., Gupta, R., & Andersson, Å. (2019) · Arthritis Research & Therapy · doi:10.1186/s13075-018-1797-3 · Cited by 13 · see citing works
“The importance of TBX3 in relation to proliferation is underpinned by studies of its role in oncogenesis [24, 25, 58, 59].”
BackgroundOverexpression of Tbx3 Predicts Poor Prognosis of Patients with Resectable Pancreatic Carcinoma
Wang, H.-C., Meng, Q.-C., Shan, Z.-Z., Yuan, Z., & Huang, X.-Y. (2015) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2015.16.4.1397 · Cited by 12 · see citing works
- Authors
- Lomnytska, M., Dubrovska, A., Hellman, U., Volodko, N., & Souchelnytskyi, S.
- Affiliations
- Uppsala University (SE)
- Danylo Halytsky Lviv National Medical University (UA)
- Corresponding author
- Souchelnytskyi, Serhiy
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2006-01-15
- Volume
- 118
- Issue
- 2
- Pages
- 412-421
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2085304717
- Cited by
- 83
- References
- 3
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 6 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 10 · 2012: 4
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Keywords
- ovarian cancer, breast cancer, plasma biomarkers, TBX3, utrophin, truncated protein isoform, early cancer detection, cancer monitoring, serum protein expression
- MeSH terms
- Breast Neoplasms, Cytosol, Female, Humans, Neoplasm Staging, Ovarian Neoplasms, Glycine Hydroxymethyltransferase, Mass Spectrometry, Biomarkers, Tumor, Electrophoresis, Gel, Two-Dimensional, Case-Control Studies, T-Box Domain Proteins, Gene Expression Profiling, Utrophin
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