Overexpression of Tbx3 Predicts Poor Prognosis of Patients with Resectable Pancreatic Carcinoma
Open accessAbstract
BACKGROUND: To determine the expressions of Tbx3, a member of subgroup belonging to T-box family, and its prognostic value in pancreatic carcinoma. MATERIALS AND METHODS: We determined the expression levels of Tbx3 on both mRNA and protein levels in 30 pairs of fresh tumor tissues and paratumor tissues by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting, respectively. In addition, protein level of Tbx3 were identified using immunochemistry in 80 pairs of paraffin-embedded specimen. The correlations between Tbx3 expression and various clinicopathological parameters as well as overall survival were evaluated. RESULTS: Tbx3 mRNA and protein levels in tumor tissues were significantly higher than in the paratumor tissues by qRT-PCR (0.05 ±0.007 vs. 0.087±0.001, p<0.001) and western blotting (1.134±0.043 vs. 0.287±0.017, p<0.001). The statistical analysis based on immunohistochemical evaluation suggested that Tbx3 aberrant expression was significantly associated with several conventional clinicopathological variables, such as gender, age, tumor position, preoperative CA19-9 level, pathological T staging and N staging. Univariate and multivariate analyses revealed that Tbx3 expression was an independent prognostic factor for overall survival (<0.001). CONCLUSIONS: Our results suggest that overexpression of Tbx3 is associated with poor prognosis of pancreatic cancer patients. However, additional clinical trials are needed to accurately validate this observation.
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TBX3 has been reported to be abnormally expressed in various carcinomas, including breast, bladder, liver, and pancreatic carcinomas.
“TBX3 has been reported to be abnormally expressed in various carcinomas, including breast, bladder, liver, and pancreatic carcinomas 25-28.”
From TBX3 shapes an immunosuppressive microenvironment and induces immunotherapy resistance (2025) · cites this paper as [27]
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- Authors
- Wang, H.-C., Meng, Q.-C., Shan, Z.-Z., Yuan, Z., & Huang, X.-Y.
- ORCID
- Yuan, Zhou
- Venue
- Asian Pacific Journal of Cancer Prevention
- Published
- 2015-03-09
- Volume
- 16
- Issue
- 4
- Pages
- 1397-1401
- ISSN
- 1513-7368 (ISSN-L)
- OpenAlex
- W2154406642
- Cited by
- 12
- References
- 32
- Citations by year
- 2025: 2 · 2023: 2 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 2
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Asian Pacific Journal of Cancer Prevention (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Science and Technology Commission of Shanghai Municipality
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Health Sciences › Medicine › Surgery › Cholangiocarcinoma and Gallbladder Cancer Studies
- Keywords
- TBX3, pancreatic cancer, prognostic factors, gene overexpression, overall survival, clinicopathological features, T-box transcription factor, resectable pancreatic cancer
- MeSH terms
- Adenocarcinoma, Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Immunoenzyme Techniques, Male, Middle Aged, Neoplasm Staging, Pancreatic Neoplasms, Prognosis, RNA, Messenger, Biomarkers, Tumor, Blotting, Western, Survival Rate, Reverse Transcriptase Polymerase Chain Reaction, T-Box Domain Proteins, Carcinoma, Pancreatic Ductal, Real-Time Polymerase Chain Reaction
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