Emerging molecular markers of cancer

A genetic model for colorectal tumorigenesis

Fearon, E. R., & Vogelstein, B. (1990) · Cell · doi:10.1016/0092-8674(90)90186-i · Cited by 12,132 · see citing works

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

Herman, J. G., Graff, J. R., Myöhänen, S., Nelkin, B. D., & Baylin, S. B. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9821 · Cited by 5,609 · see citing works

Serial Analysis of Gene Expression

Velculescu, V. E., Zhang, L., Vogelstein, B., & Kinzler, K. W. (1995) · Science · doi:10.1126/science.270.5235.484 · Cited by 3,713 · see citing works

Use of proteomic patterns in serum to identify ovarian cancer

Petricoin, E. F., Ardekani, A. M., Hitt, B. A., Levine, P. J., Fusaro, V. A., Steinberg, S. M., Mills, G. B., Simone, C., Fishman, D. A., Kohn, E. C., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07746-2 · Cited by 3,236 · see citing works

Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

Nakamura, T. M., Morin, G. B., Chapman, K. B., Weinrich, S. L., Andrews, W. H., Lingner, J., Harley, C. B., & Cech, T. R. (1997) · Science · doi:10.1126/science.277.5328.955 · Cited by 2,256 · see citing works

A gene hypermethylation profile of human cancer.

Esteller, M., Corn, P. G., Baylin, S. B., & Herman, J. G. (2001) · PubMed · Cited by 2,032 · see citing works

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

Merlo, A. U., Herman, J. G., Mao, L., Lee, D. J., Gabrielson, E. W., Burger, P. C., Baylin, S. B., & Sidransky, D. (1995) · Nature Medicine · doi:10.1038/nm0795-686 · Cited by 1,986 · see citing works

Hepatogastroenterology

Xu, D., He, X., Chang, Y., Sun, S., Xu, C., & Lin, J. (2012) · Hepatogastroenterology · doi:10.5754/hge12458 · Cited by 1,977 · see citing works

Untitled work

(1977) · PubMed · Cited by 1,801 · see citing works

DNA hypermethylation in tumorigenesis: epigenetics joins genetics

Baylin, S. B., & Herman, J. G. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(99)01971-x · Cited by 1,628 · see citing works

Parallel human genome analysis: microarray-based expression monitoring of 1000 genes.

Schena, M., Shalon, D., Heller, R. A., Chai, A., Brown, P. O., & Davis, R. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.20.10614 · Cited by 1,599 · see citing works

Genome-wide analysis of DNA copy-number changes using cDNA microarrays

Pollack, J. R., Perou, C. M., Alizadeh, A. A., Eisen, M. B., Pergamenschikov, A., Williams, C. F., Jeffrey, S. S., Botstein, D., & Brown, P. O. (1999) · Nature Genetics · doi:10.1038/12640 · Cited by 1,416 · see citing works

Aberrant methylation of p16 INK4a is an early event in lung cancer and a potential biomarker for early diagnosis

Belinsky, S. A., Nikula, K. J., Palmisano, W. A., Michels, R., Saccomanno, G., Gabrielson, E. W., Baylin, S. B., & Herman, J. G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11891 · Cited by 957 · see citing works

Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients.

Esteller, M., Sánchez‐Céspedes, M., Rosell, R., Sidransky, D., Baylin, S. B., & Herman, J. G. (1999) · PubMed · Cited by 921 · see citing works

Identification of p53 Gene Mutations in Bladder Cancers and Urine Samples

Sidransky, D., von Eschenbach, A., Tsai, Y., Jones, P. A., Summerhayes, I. C., Marshall, F. F., Paul, M., Green, P., Hamilton, S. R., Frost, P., et al. (1991) · Science · doi:10.1126/science.2024123 · Cited by 875 · see citing works

Somatic mutations of the mitochondrial genome in human colorectal tumours

Polyák, K., Li, Y., Zhu, H., Christoph Lengauer, C., Willson, J. K. V., Markowitz, S. D., Trush, M. A., Kinzler, K. W., & Vogelstein, B. (1998) · Nature Genetics · doi:10.1038/3108 · Cited by 834 · see citing works

Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.

Salonga, D. S., Danenberg, K. D., Johnson, M. R., Metzger, R., Groshen, S. G., Tsao-Wei, D. D., Lenz, H.-J., Leichman, C. G., Leichman, L., Diasio, R. B., et al. (2000) · PubMed · Cited by 829 · see citing works

Facile Detection of Mitochondrial DNA Mutations in Tumors and Bodily Fluids

Fliss, M., Usadel, H., Caballero, O. L., Wu, L. J., Buta, M. R., Eleff, S. M., Jen, J., & Sidransky, D. (2000) · Science · doi:10.1126/science.287.5460.2017 · Cited by 821 · see citing works

Predicting lung cancer by detecting aberrant promoter methylation in sputum.

Palmisano, W. A., Divine, K. K., Saccomanno, G., Gilliland, F. D., Baylin, S. B., Herman, J. G., & Belinsky, S. A. (2000) · PubMed · Cited by 816 · see citing works

Molecular Assessment of Histopathological Staging in Squamous-Cell Carcinoma of the Head and Neck

Brennan, J. A., Mao, L., Hruban, R. H., Boyle, J. O., Eby, Y. J., Koch, W. M., Goodman, S. N., & Sidransky, D. (1995) · New England Journal of Medicine · doi:10.1056/nejm199502163320704 · Cited by 749 · see citing works

Cochrane review on screening for breast cancer with mammography

Olsen, O., & Gøtzsche, P. C. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06449-2 · Cited by 714 · see citing works

Identification of ras Oncogene Mutations in the Stool of Patients with Curable Colorectal Tumors

Sidransky, D., Tokino, T., Hamilton, S. R., Kinzler, K. W., Levin, B., Frost, P., & Vogelstein, B. (1992) · Science · doi:10.1126/science.1566048 · Cited by 696 · see citing works

Microsatellite alterations in serum DNA of head and neck cancer patients

Nawroz, H., Koch, W. M., Anker, P., Stroun, M., & Sidransky, D. (1996) · Nature Medicine · doi:10.1038/nm0996-1035 · Cited by 656 · see citing works

Microsatellite alterations in plasma DNA of small cell lung cancer patients

Chen, X. Q., Stroun, M., Magnenat, J.-L., Nicod, L. P., Kurt, A.-M., Lyautey, J., Lederrey, C., & Anker, P. (1996) · Nature Medicine · doi:10.1038/nm0996-1033 · Cited by 647 · see citing works

Detection of melanoma cells in peripheral blood by means of reverse transcriptase and polymerase chain reaction

Smith, B., Selby, P. J., Southgate, J., Pittman, K. B., Bradley, C., & Blair, G. E. (1991) · The Lancet · doi:10.1016/0140-6736(91)92100-g · Cited by 630 · see citing works

HER-2 tyrosine kinase pathway targets estrogen receptor and promotes hormone-independent growth in human breast cancer cells.

Pietras, R. J., Arboleda, J., Dm, R., Wongvipat, N., Pegram, M. D., Ramos, L., Cm, G., Mg, P., Sliwkowski, M. X., & Dj, S. (1995) · PubMed · Cited by 603 · see citing works

Micrometastases and Survival in Stage II Colorectal Cancer

Liefers, G., Cleton-Jansen, A., van de Velde, C. J. �., Hermans, J., van Krieken, J. H. J. M., Cornelisse, C. J., & Tollenaar, R. A. �. �. (1998) · New England Journal of Medicine · doi:10.1056/nejm199807233390403 · Cited by 586 · see citing works

Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE).

Argani, P., Iacobuzio–Donahue, C. A., Ryu, B., Rosty, C., Goggins, M., Wilentz, R. E., Murugesan, S. R., Leach, S. D., Jaffee, E. M., Yeo, C. J., et al. (2001) · PubMed · Cited by 574 · see citing works

Gene promoter hypermethylation in tumors and serum of head and neck cancer patients.

Sánchez‐Céspedes, M., Esteller, M., Wu, L. J., Nawroz-Danish, H., Yoo, G., Koch, W. M., Jen, J., Herman, J. G., & Sidransky, D. (2000) · PubMed · Cited by 540 · see citing works

Colorectal cancer screening by detection of altered human DNA in stool: Feasibility of a multitarget assay panel

Ahlquist, D. A., Skoletsky, J., Boynton, K. A., Harrington, J. J., Mahoney, D. W., Pierceall, W. E., Thibodeau, S. N., & Shuber, A. P. (2000) · Gastroenterology · doi:10.1053/gast.2000.19580 · Cited by 526 · see citing works

Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity

Wright, W. E., Shay, J. W., & Piatyszek, M. A. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.18.3794 · Cited by 475 · see citing works

Microsatellite alterations as clonal markers for the detection of human cancer.

Mao, L., Lee, D. J., Tockman, M. S., Erozan, Y. S., Askin, F. B., & Sidransky, D. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.9871 · Cited by 447 · see citing works

Sensitive detection of occult breast cancer by the reverse-transcriptase polymerase chain reaction.

Datta, Y. H., Adams, P., Drobyski, W. R., Ethier, S. P., Terry, V. H., & Roth, M. S. (1994) · Journal of Clinical Oncology · doi:10.1200/jco.1994.12.3.475 · Cited by 417 · see citing works

Promoter hypermethylation patterns of p16, O6-methylguanine-DNA-methyltransferase, and death-associated protein kinase in tumors and saliva of head and neck cancer patients.

Rosas, S. L. B., Koch, W. M., Carvalho, M. D. G., Wu, L., Califano, J. A., Westra, W. H., Jen, J., & Sidransky, D. (2001) · PubMed · Cited by 409 · see citing works

Determination of circulating DNA levels in patients with benign or malignant gastrointestinal disease

Shapiro, B., Chakrabarty, M., Cohn, E. M., & Leon, S. A. (1983) · Cancer · doi:10.1002/1097-0142(19830601)51:11 · Cited by 398 · see citing works

Quantitative and temporal correlation between circulating cell-free Epstein-Barr virus DNA and tumor recurrence in nasopharyngeal carcinoma.

Lo, Y. M. D., Chan, L. Y. S., Chan, A. T. �., Leung, S. F., Lo, K. W., Zhang, J., Lee, J. C., Hjelm, N. M., Johnson, P. J., & Huang, D. P. (1999) · PubMed · Cited by 389 · see citing works

Vasculogenesis, Angiogenesis, and Growth Factors: Ephrins Enter the Fray at the Border

Yancopoulos, G. D., Klagsbrun, M., & Folkman, J. (1998) · Cell · doi:10.1016/s0092-8674(00)81426-9 · Cited by 383 · see citing works

Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonucleotide arrays

Hacia, J. G., Fan, J., Ryder, O. A., Li, J., Edgemon, K., Ghandour, G., Mayer, R. A., Sun, B. K., Hsie, L., Robbins, C. M., et al. (1999) · Nature Genetics · doi:10.1038/9674 · Cited by 380 · see citing works

Molecular Detection of Primary Bladder Cancer by Microsatellite Analysis

Mao, L., Schoenberg, M., Scicchitano, M. S., Erozan, Y. S., Merlo, A. U., Schwab, D., & Sidransky, D. (1996) · Science · doi:10.1126/science.271.5249.659 · Cited by 377 · see citing works

Hypermethylated APC DNA in Plasma and Prognosis of Patients With Esophageal Adenocarcinoma

Kawakami, K. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.22.1805 · Cited by 376 · see citing works

Specific detection of carcinoembryonic antigen-expressing tumor cells in bone marrow aspirates by polymerase chain reaction.

Gerhard, M., Juhl, H., Kalthoff, H., Schreiber, H. W., Wagener, C., & Neumaier, M. (1994) · Journal of Clinical Oncology · doi:10.1200/jco.1994.12.4.725 · Cited by 369 · see citing works

Molecular prognostication of nasopharyngeal carcinoma by quantitative analysis of circulating Epstein-Barr virus DNA.

Lo, Y. M. D., Chan, A. T. �., Chan, L. Y. S., Leung, S. F., Lam, C., Huang, D. P., & Johnson, P. J. (2000) · PubMed · Cited by 341 · see citing works

Molecular Detection of Tumor Cells in Bronchoalveolar Lavage Fluid From Patients With Early Stage Lung Cancer

Ahrendt, S. A., Chow, J. T., Xu, L., Yang, S., Eisenberger, C. F., Esteller, M., Herman, J. G., Wu, L. J., Decker, P. A., Jen, J., et al. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.4.332 · Cited by 341 · see citing works

Detecting Colorectal Cancer in Stool With the Use of Multiple Genetic Targets

Dong, S. M., Traverso, G., Johnson, C., Geng, L., Favis, R., Boynton, K. A., Hibi, K., Goodman, S. N., D’Allessio, M., Paty, P. B., et al. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.11.858 · Cited by 338 · see citing works

Detection ofAPCMutations in Fecal DNA from Patients with Colorectal Tumors

Traverso, G., Shuber, A. P., Levin, B., Johnson, C., Olsson, L., Schoetz, D. J., Hamilton, S. R., Boynton, K. A., Kinzler, K. W., & Vogelstein, B. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012294 · Cited by 325 · see citing works

Serum p53 antibodies as early markers of lung cancer

Lubin, R., Zalcman, G., Bouchet, L., Trédaniel, J., Legros, Y., Cazals-Hatem, D. L., Hirsch, A., & Soussi, T. (1995) · Nature Medicine · doi:10.1038/nm0795-701 · Cited by 317 · see citing works

Quantitation of GSTP1 Methylation in Non-neoplastic Prostatic Tissue and Organ-Confined Prostate Adenocarcinoma

Jerónimo, C., Usadel, H., Henrique, R., Oliveira, J., Lopes, C., Nelson, W. G., & Sidransky, D. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.22.1747 · Cited by 306 · see citing works

Proteomics-based identification of RS/DJ-1 as a novel circulating tumor antigen in breast cancer.

Naour, F. L., Misek, D. E., Krause, M. C., Deneux, L., Giordano, T. J., Scholl, S., & Hanash, S. (2001) · PubMed · Cited by 306 · see citing works

Quantitative adenomatous polyposis coli promoter methylation analysis in tumor tissue, serum, and plasma DNA of patients with lung cancer.

Usadel, H., Brabender, J., Danenberg, K. D., Jerónimo, C., Harden, S., Engles, J. M., Danenberg, P. V., Yang, S. S., & Sidransky, D. (2002) · PubMed · Cited by 302 · see citing works

Limitations of reverse-transcriptase polymerase chain reaction analyses for detection of micrometastatic epithelial cancer cells in bone marrow.

Zippelius, A., Kufer, P., Honold, G., Köllermann, M. W., Oberneder, R., Schlimok, G., Riethmüller, G., & Pantel, K. (1997) · Journal of Clinical Oncology · doi:10.1200/jco.1997.15.7.2701 · Cited by 274 · see citing works

Detection of bladder cancer recurrence by microsatellite analysis of urine

Steiner, G., Schoenberg, M., Linn, J. F., Mao, L., & Sidransky, D. (1997) · Nature Medicine · doi:10.1038/nm0697-621 · Cited by 270 · see citing works

Proteomics in Early Detection of Cancer

Srinivas, P. R., Srivastava, S., Hanash, S., & Wright, G. L. (2001) · Clinical Chemistry · doi:10.1093/clinchem/47.10.1901 · Cited by 252 · see citing works

Identification of a mononucleotide repeat as a major target for mitochondrial DNA alterations in human tumors.

Sánchez‐Céspedes, M., Parrella, P., Nomoto, S., Cohen, D., Xiao, Y. Q., Esteller, M., Jerónimo, C., Jordan, R. C. K., Nicol, T. L., Koch, W. M., et al. (2001) · PubMed · Cited by 236 · see citing works

Rapid p53 sequence analysis in primary lung cancer using an oligonucleotide probe array

Ahrendt, S. A., Halachmi, S., Chow, J. T., Li, W., Halachmi, N., Yang, S. C., Wehage, S. L., Jen, J., & Sidransky, D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7382 · Cited by 228 · see citing works

Detection of aberrantly methylated hMLH1 promoter DNA in the serum of patients with microsatellite unstable colon cancer

Grady, W. M., Raiput, A., Lutterbaugh, J., & Markowitz, S. D. (2001) · Gastroenterology · doi:10.1016/s0016-5085(01)81443-8 · Cited by 224 · see citing works

Isoelectric Focusing Nonporous RP HPLC: A Two-Dimensional Liquid-Phase Separation Method for Mapping of Cellular Proteins with Identification Using MALDI-TOF Mass Spectrometry

Wall, D. B., Kachman, M. T., Gong, S., Hinderer, R., Parus, S., Misek, D. E., Hanash, S., & Lubman, D. M. (2000) · Analytical Chemistry · doi:10.1021/ac991332t · Cited by 211 · see citing works

Proteomics-based identification of protein gene product 9.5 as a tumor antigen that induces a humoral immune response in lung cancer.

Brichory, F., Beer, D., Naour, F. L., Giordano, T. J., & Hanash, S. (2001) · PubMed · Cited by 204 · see citing works

Detection and quantitation of human papillomavirus (HPV) DNA in the sera of patients with HPV-associated head and neck squamous cell carcinoma.

Capone, R. B., Pai, S. I., Koch, W. M., Gillison, M. L., Nawroz-Danish, H., Westra, W. H., Daniel, R. W., Shah, K. V., & Sidransky, D. (2000) · PubMed · Cited by 188 · see citing works

Low specificity of cytokeratin 19 reverse transcriptase-polymerase chain reaction analyses for detection of hematogenous lung cancer dissemination.

Krismann, M., Todt, B., Schröder, J., Gareis, D., Müller, K., Seeber, S., & Schütte, J. (1995) · Journal of Clinical Oncology · doi:10.1200/jco.1995.13.11.2769 · Cited by 186 · see citing works

Detection of head and neck squamous cell carcinoma among exfoliated oral mucosal cells by microsatellite analysis.

Spafford, M. F., Koch, W. M., Reed, A. L., Califano, J. A., Xu, L., Eisenberger, C. F., Yip, L., Leong, P. L., Wu, L., Liu, S. X., et al. (2001) · PubMed · Cited by 170 · see citing works

The detection of melanoma cells in peripheral blood by reverse transcription-polymerase chain reaction

Foss, A. J. E., Guille, M., Occleston, N. L., Hykin, P. G., Hungerford, J. L., & Lightman, S. (1995) · British Journal of Cancer · doi:10.1038/bjc.1995.293 · Cited by 165 · see citing works

K-ras oncogene subtype mutations are associated with survival but not expression of p53, p16INK4A, p21WAF-1, cyclin D1, erbB-2 and erbB-3 in resected pancreatic ductal adenocarcinoma

Kawesha, A., Ghaneh, P., Andrén‐Sandberg, Å., Ögraed, D., Skar, R., Dawiskiba, S., Evans, J. D., Campbell, F., Lemoine, N. R., & Neoptolemos, J. P. (2000) · International Journal of Cancer · doi:10.1002/1097-0215(20001120)89:6 · Cited by 149 · see citing works

Detection of occult metastatic breast cancer cells in blood by a multimolecular marker assay: correlation with clinical stage of disease.

Taback, B., Chan, A. D., Kuo, C. T., Bostick, P. J., Wang, H.-J., Giuliano, A. E., & Hoon, D. S. �. (2001) · PubMed · Cited by 147 · see citing works

Cancer proteomics: from biomarker discovery to signal pathway profiling.

Bichsel, V. E., Liotta, L. A., & Petricoin, E. (2001) · PubMed · Cited by 127 · see citing works

A polymerase chain reaction-based semiquantitative assessment of malignant melanoma cells in peripheral blood.

Brossart, P., Schmier, J. W., Krüger, S., Willhauck, M., Scheibenbogen, C., Möhler, T., & Keilholz, U. (1995) · PubMed · Cited by 123 · see citing works

Protein based microarrays: A tool for probing the proteome of cancer cells and tissues

Madoz‐Gúrpide, J., Wang, H., Misek, D. E., Brichory, F., & Hanash, S. (2001) · PROTEOMICS · doi:10.1002/1615-9861(200110)1:10 · Cited by 122 · see citing works

New technologies for biomarker analysis of prostate cancer progression: Laser capture microdissection and tissue proteomics

Paweletz, C. P., Liotta, L. A., & Petricoin, E. F. (2001) · Urology · doi:10.1016/s0090-4295(00)00964-x · Cited by 120 · see citing works

Detection of K-ras Oncogene Mutations in Bronchoalveolar Lavage Fluid for Lung Cancer Diagnosis

Mills, N. E., Fishman, C. L., Scholes, J. V., Anderson, S. E., Rom, W. N., & Jacobson, D. R. (1995) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/87.14.1056 · Cited by 120 · see citing works

Osteogenic sarcoma of the extremity with detectable lung metastases at presentation

Bacci, G., Mercuri, M., Briccoli, A., Ferrari, S., Bertoni, F., Donati, D. M., Monti, C., Zanoni, A., Forni, C., & Manfrini, M. (1997) · Cancer · doi:10.1002/(sici)1097-0142(19970115)79:2 · Cited by 119 · see citing works

p16 is a major inactivation target in hepatocellular carcinoma

Baek, M. J., Piao, Z., Kim, N., Park, C., Shin, E., Park, J. H., Jung, H., Kim, C. G., & Kim, H. (2000) · Cancer · doi:10.1002/1097-0142(20000701)89:1 · Cited by 116 · see citing works

Detection of telomerase activity in oral rinses from head and neck squamous cell carcinoma patients.

Califano, J. A., Ahrendt, S. A., Meininger, G. R., Westra, W. H., Koch, W. M., & Sidransky, D. (1996) · PubMed · Cited by 109 · see citing works

Genetic diagnosis identifies occult lymph node metastases undetectable by the histopathological method.

Hayashi, N., Arakawa, H., Nagase, H., Yanagisawa, A., Kato, Y., Ohta, H., Takano, S., Ogawa, M., & Nakamura, Y. (1994) · PubMed · Cited by 106 · see citing works

Proteomic Approaches within the NCI Early Detection Research Network for the Discovery and Identification of Cancer Biomarkers

Verma, M., Wright, G. L., Hanash, S., Gopal-Srivastava, R., & Srivastava, S. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03870.x · Cited by 106 · see citing works

Specific p53 mutations detected in plasma and tumors of hepatocellular carcinoma patients by electrospray ionization mass spectrometry.

Jackson, P. E., Qian, G., Friesen, M. D., Zhu, Y. R., Lu, P., Wang, J. B., Wu, Y., Kensler, T. W., Vogelstein, B., & Groopman, J. D. (2001) · PubMed · Cited by 105 · see citing works

Detection of K-ras Mutation in Colonic Effluent Samples From Patients Without Evidence of Colorectal Carcinoma

Tohi, M., Luo, F., & Ronai, Z. A. (1994) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/86.13.1007 · Cited by 102 · see citing works

Comparison of Methods of Measuring HER-2 in Metastatic Breast Cancer Patients Treated With High-Dose Chemotherapy

Harris, L. N., Liotcheva, V. B., Broadwater, G., Ramirez, M. J., Maimonis, P. J., Anderson, S., Everett, T., Harpole, D. H., Moore, M. B., Berry, D. A., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.6.1698 · Cited by 96 · see citing works

Fine-needle aspiration of the adult kidney

Renshaw, A. A., Granter, S. R., & Cibas, E. S. (1997) · Cancer · doi:10.1002/(sici)1097-0142(19970425)81:2 · Cited by 96 · see citing works

Circulating nucleic acids in plasma or serum

Anker, P., Lyautey, J., Lederrey, C., & Stroun, M. (2001) · Clinica Chimica Acta · doi:10.1016/s0009-8981(01)00666-0 · Cited by 95 · see citing works

Entering the Postgenome Era

Nowak, R. (1995) · Science · doi:10.1126/science.270.5235.368 · Cited by 90 · see citing works

Detection of telomerase activity in exfoliated cancer cells in colonic luminal washings and its related clinical implications

Yoshida, K., Sugino, T., Steve Goodison, B., Warren, B., Nolan, D. J., Wadsworth, S. J., Mortensen, N., Toge, T., Tahara, E., & Tarin, D. (1997) · British Journal of Cancer · doi:10.1038/bjc.1997.96 · Cited by 80 · see citing works

Induction of thymidylate synthase associated with multidrug resistance in human breast and colon cancer cell lines.

Chu, E., Drake, J. C., Koeller, D. M., Zinn, S., Jamis‐Dow, C., Yeh, G. C., & Allegra, C. J. (1991) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10875-4 · Cited by 67 · see citing works

History of maternal fetal loss and increased risk of childhood acute leukemia at an early age. A report from the childrens cancer group

Yeazel, M. W., Woods, W. G., Robison, L. L., Buckley, J. D., & Ruccione, K. (1995) · Cancer · doi:10.1002/1097-0142(19950401)75:7 · Cited by 58 · see citing works

NCCN Practice Guidelines for Colorectal Cancer.

Benson, A. B., Choti, M. A., Cohen, A. M., Doroshow, J. H., Fuchs, C., Kiel, K. D., Martin, E., McGinn, C. J., Petrelli, N. J., Posey, J. A., et al. (2000) · PubMed · Cited by 58 · see citing works

Detection of tumor mutations in the presence of excess amounts of normal DNA

Sun, X., Hung, K., Wu, L. J., Sidransky, D., & Guo, B. (2002) · Nature Biotechnology · doi:10.1038/nbt0202-186 · Cited by 53 · see citing works

Loss of Heterozygosity Assay for Molecular Detection of Cancer Using Energy-transfer Primers and Capillary Array ElectrophoresisPreprint

Medintz, I. L., Lee, C. R., Wong, W. W., Pirkola, K., Sidransky, D., & Mathies, R. A. (2000) · Genome Research · doi:10.1101/gr.10.8.1211 · Cited by 53 · see citing works

Preoperative values of CA 15-3 and CEA as prognostic factors in breast cancer: a multivariate analysis.

izares, F. C. N., Sola, J. J., rez, M. P. E., Tovar, I., Heras, M. D. L., Salinas, J., afiel, R. P. N., & Nez, P. (2001) · Tumor Biology · doi:10.1159/000050627 · Cited by 50 · see citing works

Über Wachstum von Krebszellen in Medien, deren Glucose durch Galaktose ersetzt ist

Warburg, O. H., Geissler, A. W., & Lorenz, S. (1967) · Hoppe-Seyler´s Zeitschrift für physiologische Chemie · doi:10.1515/bchm2.1967.348.1.1686 · Cited by 46 · see citing works

Computational gene discovery and human disease

Rawlings, C., & Searls, D. B. (1997) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(97)80158-x · Cited by 36 · see citing works

Differences in Sensitivity of Biological Functions Mediated by Epidermal Growth Factor Receptor Activation with Respect to Endogenous and Exogenous Ligands

Sawhney, R. S., Zhou, G.-H. K., Humphrey, L. E., Ghosh, P., Kreisberg, J. I., & Brattain, M. G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m103268200 · Cited by 34 · see citing works

[On growth of cancer cells in media in which glucose is replaced by galactose].

Warburg, O. H., Geissler, A. W., & Lorenz, S. (1967) · PubMed · Cited by 32 · see citing works

Serum tumour markers CA 15-3, TPA, TPS, hCG β and TATI in the monitoring of chemotherapy response in metastatic breast cancer

Sjöström, J., Alfthan, H. V., Joensuu, H., Stenman, U., Lundin, J. E., & BLOMQVIST, C. P. (2001) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510152567068 · Cited by 30 · see citing works

Tests for carcinoembryonic antigen. Role in diagnosis and management of cancer

Gold, P. (1975) · JAMA · doi:10.1001/jama.234.2.190 · Cited by 23 · see citing works

2-D or not 2-D--is there a future for 2-D gels in proteomics? Insights from the York proteomics meeting.

Hanash, S. (2001) · PubMed · Cited by 21 · see citing works

Advances in the treatment of non-small cell lung cancer: Molecular markers take the stage

Rosell, R. (2001) · Seminars in Oncology · doi:10.1016/s0093-7754(01)90301-x · Cited by 20 · see citing works

Prospective evaluation of the contribution of K-ras mutational analysis and CA 19.9 measurement to cytological diagnosis in patients with clinical suspicion of pancreatic cancer

Urgell, E., Puig, P., Boadas, J., Capellá, G., Queraltó, J. M., Boluda, R., Antonijuan-Parés, A., Farré, A., Lluı́s, F., González‐Sastre, F., et al. (2000) · European Journal of Cancer · doi:10.1016/s0959-8049(00)00288-4 · Cited by 18 · see citing works

Serum p53 antibodies in small cell lung cancer: the lack of prognostic relevance

Jassem, E., Bigda, J., Dziadziuszko, R., Schlichtholz, B., Roux, D. L., Grodzki, T., Rzyman, W., Konopa, K., Pobereżna, M., Dobrzańska, Z., et al. (2001) · Lung Cancer · doi:10.1016/s0169-5002(00)00150-1 · Cited by 15 · see citing works

Tests for Carcinoembryonic Antigen

Gold, P. (1975) · JAMA · doi:10.1001/jama.1975.03260150060026 · Cited by 15 · see citing works

Diagnosis of localized prostate cancer: 10 years of progress

Feneley, M. R., & Partin, A. W. (2000) · Current Opinion in Urology · doi:10.1097/00042307-200007000-00006 · Cited by 13 · see citing works

Utility of serum CA 19-9 monitoring in preoperative radiotherapy for pancreatic cancer.

Ohara, K., Tatsuzaki, H., Molotkova, N. G., Oda, T., Yuzawa, K., Saida, Y., Matsuzaki, Y., Shimizu, W., Todoroki, T., Fukao, K., et al. (2001) · PubMed · Cited by 13 · see citing works

The fundamental role of epigenetic events in cancer

Jones, P. A., & Baylin, S. B. (2002) · Nature Reviews Genetics · doi:10.1038/nrg816 · Cited by 5,648 · see citing works

Cancer genes and the pathways they control

Vogelstein, B., & Kinzler, K. W. (2004) · Nature Medicine · doi:10.1038/nm1087 · Cited by 4,245 · see citing works

Circulating mutant DNA to assess tumor dynamics

Diehl, F., Schmidt, K., Choti, M. A., Romans, K. E., Goodman, S. N., Li, M., Thornton, K. A., Agrawal, N., Sokoll, L. J., Szabo, S., et al. (2008) · Nature Medicine · doi:10.1038/nm.1789 · Cited by 2,747 · see citing works

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

Yachida, S., Jones, S., Bozic, I., Antal, T., Leary, R., Fu, B., Kamiyama, M., Hruban, R. H., Eshleman, J. R., Nowak, M. A., et al. (2010) · Nature · doi:10.1038/nature09515 · Cited by 2,502 · see citing works

Multiplexed electrical detection of cancer markers with nanowire sensor arrays

Zheng, G., Patolsky, F., Cui, Y., Wang, W. U., & Lieber, C. M. (2005) · Nature Biotechnology · doi:10.1038/nbt1138 · Cited by 2,430 · see citing works

Radical causes of cancer

Hussain, S. P., Hofseth, L. J., & Harris, C. C. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1046 · Cited by 1,690 · see citing works

Biomarkers in Cancer Staging, Prognosis and Treatment Selection

Ludwig, J. A., & Weinstein, J. N. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1739 · Cited by 1,655 · see citing works

The power and the promise of DNA methylation markers

Laird, P. W. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1045 · Cited by 1,548 · see citing works

Multimodal biomedical AI

Acosta, J. N., Falcone, G. J., Rajpurkar, P., & Topol, E. J. (2022) · Nature Medicine · doi:10.1038/s41591-022-01981-2 · Cited by 1,365 · see citing works

Detection and quantification of mutations in the plasma of patients with colorectal tumors

Diehl, F., Li, M., Dressman, D., He, Y., Shen, D., Szabo, S., Diaz, L. A., Goodman, S. N., David, K. A., Juhl, H., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507904102 · Cited by 1,188 · see citing works

CpG island methylator phenotype in cancer

Issa, J. J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1507 · Cited by 1,107 · see citing works

Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles

Sugimoto, M., Wong, D. T., Hirayama, A., Soga, T., & Tomita, M. (2009) · Metabolomics · doi:10.1007/s11306-009-0178-y · Cited by 999 · see citing works

Proteomic applications for the early detection of cancer

Wulfkuhle, J. D., Liotta, L. A., & Petricoin, E. F. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1043 · Cited by 902 · see citing works

Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations

Dressman, D. C., Yan, H., Traverso, G., Kinzler, K. W., & Vogelstein, B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1133470100 · Cited by 845 · see citing works

An autonomous molecular computer for logical control of gene expression

Benenson, Y., Gil, B., Ben-Dor, U., Adar, R., & Shapiro, E. Y. (2004) · Nature · doi:10.1038/nature02551 · Cited by 816 · see citing works

Differential exoprotease activities confer tumor-specific serum peptidome patterns

Villanueva, J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26022 · Cited by 737 · see citing works

Salivary Transcriptome Diagnostics for Oral Cancer Detection

Li, Y., John, M. A. R. S., Zhou, X. C., Kim, Y., Sinha, U. K., Jordan, R. C., Eisele, D. W., Abemayor, E., Elashoff, D. A., Park, N., et al. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1167 · Cited by 629 · see citing works

Chip–NMR biosensor for detection and molecular analysis of cells

Lee, H., Sun, E., Ham, D., & Weissleder, R. (2008) · Nature Medicine · doi:10.1038/nm.1711 · Cited by 621 · see citing works

Mitochondrial DNA mutations in human cancer

Chatterjee, A., Mambo, E., & Sidransky, D. (2006) · Oncogene · doi:10.1038/sj.onc.1209604 · Cited by 586 · see citing works

The genetics and genomics of cancer

Balmain, A., Gray, J. W., & Ponder, B. A. J. (2003) · Nature Genetics · doi:10.1038/ng1107 · Cited by 573 · see citing works

Heteroplasmic mitochondrial DNA mutations in normal and tumour cells

He, Y., Wu, J., Dressman, D. C., Iacobuzio–Donahue, C. A., Markowitz, S. D., Velculescu, V. E., Diaz, L. A., Kinzler, K. W., Vogelstein, B., & Papadopoulos, N. (2010) · Nature · doi:10.1038/nature08802 · Cited by 516 · see citing works

MGMT Promoter Methylation and Field Defect in Sporadic Colorectal Cancer

Shen, L., Kondo, Y., Rosner, G. L., Xiao, L., Hernandez, N., Vilaythong, J. N., Houlihan, P., Krouse, R. S., Prasad, A. R., Einspahr, J. G., et al. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji275 · Cited by 492 · see citing works

Nanowire Sensors for Medicine and The Life Sciences

Patolsky, F., Zheng, G., & Lieber, C. M. (2006) · Nanomedicine · doi:10.2217/17435889.1.1.51 · Cited by 489 · see citing works

Biomarkers in Cancer Detection, Diagnosis, and Prognosis

Das, S., Dey, M. K., Devireddy, R. V., & Gartia, M. R. (2023) · Sensors · doi:10.3390/s24010037 · Cited by 445 · see citing works

Profiling early head and neck cancer

Hunter, K. D., Parkinson, E. K., & Harrison, P. R. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1549 · Cited by 436 · see citing works

Interleukin 6 and Interleukin 8 as Potential Biomarkers for Oral Cavity and Oropharyngeal Squamous Cell Carcinoma

John, M. A. R. S., Li, Y., Zhou, X. C., Denny, P., Ho, C., Montemagno, C. D., Shi, W., Qi, F., Wu, B. M., Sinha, U. K., et al. (2004) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archotol.130.8.929 · Cited by 424 · see citing works

Multiplexed Detection of Protein Cancer Markers with Biobarcoded Nanoparticle Probes

Stoeva, S. I., Lee, J., Smith, J., Rosen, S. T., & Mirkin, C. A. (2006) · Journal of the American Chemical Society · doi:10.1021/ja0613106 · Cited by 420 · see citing works

Cellular Traction Stresses Increase with Increasing Metastatic Potential

Kraning-Rush, C. M., Califano, J. P., & Reinhart‐King, C. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032572 · Cited by 393 · see citing works

Oral Cavity and Esophageal Carcinogenesis Modeled in Carcinogen-Treated Mice

Tang, X., Knudsen, B. S., Bemis, D. L., Tickoo, S. K., & Gudas, L. J. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-0999-3 · Cited by 390 · see citing works

Sensitive digital quantification of DNA methylation in clinical samples

Li, M., Chen, W.-D., Papadopoulos, N., Goodman, S. N., Bjerregaard, N. C., Laurberg, S., Levin, B., Juhl, H., Arber, N., Moinova, H., et al. (2009) · Nature Biotechnology · doi:10.1038/nbt.1559 · Cited by 341 · see citing works

Epigenetic changes in colorectal cancer

Kondo, Y., & Issa, J. J. (2003) · Cancer and Metastasis Reviews · doi:10.1023/a:1025806911782 · Cited by 335 · see citing works

Nanotechnology for Early Cancer Detection

Choi, Y., Kwak, J., & Park, J. W. (2010) · Sensors · doi:10.3390/s100100428 · Cited by 329 · see citing works

Discovery of novel targets for aberrant methylation in pancreatic carcinoma using high-throughput microarrays.

Sato, N., Fukushima, N., Maitra, A., Matsubayashi, H., Yeo, C. J., Cameron, J. L., Hruban, R. H., & Goggins, M. (2003) · PubMed · Cited by 328 · see citing works

DNA methylation markers in colorectal cancer

Kim, M. S., Lee, J., & Sidransky, D. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9207-6 · Cited by 302 · see citing works

Tumor Cell-Specific BRCA1 and RASSF1A Hypermethylation in Serum, Plasma, and Peritoneal Fluid from Ovarian Cancer Patients

de Cáceres, I. I., Battagli, C., Esteller, M., Herman, J. G., Dulaimi, E., Edelson, M. I., Bergman, C. A., Ehya, H., Eisenberg, B. L., & Cairns, P. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1529 · Cited by 280 · see citing works

Predictive and prognostic biomarkers in colorectal cancer: A systematic review of recent advances and challenges

Das, V., Kalita, J., & Pal, M. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.12.064 · Cited by 276 · see citing works

Immunohistochemical Detection of EGFRvIII in High Malignancy Grade Astrocytomas and Evaluation of Prognostic Significance

Aldape, K., Ballman, K. V., Furth, A. F., Buckner, J. C., Giannini, C., Burger, P. C., Scheithauer, B. W., Jenkins, R. B., & James, C. D. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.7.700 · Cited by 275 · see citing works

Progress in Chemoprevention Drug Development: The Promise of Molecular Biomarkers for Prevention of Intraepithelial Neoplasia and Cancer—A Plan to Move Forward

Kelloff, G. J., Lippman, S. M., Dannenberg, A. J., Sigman, C. C., Pearce, H. L., Reid, B. J., Szabo, E. M., Jordan, V. C., Spitz, M. R., Mills, G. B., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1104 · Cited by 269 · see citing works

Silicon nanowire biosensor and its applications in disease diagnostics: A review

Zhang, G., & Ning, Y. (2012) · Analytica Chimica Acta · doi:10.1016/j.aca.2012.08.035 · Cited by 267 · see citing works

A Quantitative Promoter Methylation Profile of Prostate Cancer

Jerónimo, C., Henrique, R., Hoque, M. O., Mambo, E., Ribeiro, F. R., Varzim, G., Oliveira, J., Teixeira, M. R., Lopes, C., & Sidransky, D. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0894 · Cited by 259 · see citing works

RNA Profiling of Cell-free Saliva Using Microarray Technology

Li, Y., Zhou, X. C., John, M., & Wong, D. T. (2004) · Journal of Dental Research · doi:10.1177/154405910408300303 · Cited by 255 · see citing works

Cancer biomarkers: selecting the right drug for the right patient

Kelloff, G. J., & Sigman, C. C. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3651 · Cited by 253 · see citing works

Targeted Modulation of MGMT: Clinical Implications

Liu, L., & Gerson, S. L. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2543 · Cited by 245 · see citing works

Profiling epigenetic inactivation of tumor suppressor genes in tumors and plasma from cutaneous melanoma patients

Hoon, D. S. �., Spugnardi, M., Kuo, C. T., Huang, S. K., Morton, D. L., & Taback, B. (2004) · Oncogene · doi:10.1038/sj.onc.1207505 · Cited by 242 · see citing works

Cancer Biomarkers: Are We Ready for the Prime Time?

Mishra, A., & Verma, M. (2010) · Cancers · doi:10.3390/cancers2010190 · Cited by 241 · see citing works

Nanobiosensors: optofluidic, electrical and mechanical approaches to biomolecular detection at the nanoscale

Erickson, D., Mandal, S., Yang, A. H. J., & Cordovez, B. (2007) · Microfluidics and Nanofluidics · doi:10.1007/s10404-007-0198-8 · Cited by 241 · see citing works

Cancer biomarkers - current perspectives.

Bhatt, A. N., Mathur, R., Farooque, A., Verma, A., & Dwarakanath, B. S. R. (2010) · PubMed · Cited by 238 · see citing works

Predictive value of the EphA2 receptor tyrosine kinase in lung cancer recurrence and survival.

Kinch, M. S., Moore, M.-B. H., & Harpole, D. H. (2003) · PubMed · Cited by 235 · see citing works

Diagnostic and Prognostic Epigenetic Biomarkers in Cancer

Costa‐Pinheiro, P., Montezuma, D., Henrique, R., & Jerónimo, C. (2015) · Epigenomics · doi:10.2217/epi.15.56 · Cited by 232 · see citing works

Surface Plasmon Resonance (SPR) Sensor for Cancer Biomarker Detection

Das, S., Devireddy, R. V., & Gartia, M. R. (2023) · Biosensors · doi:10.3390/bios13030396 · Cited by 230 · see citing works

Tumor Suppressor Gene Promoter Hypermethylation in Serum of Breast Cancer Patients

Dulaimi, E., Hillinck, J., de Cáceres, I. I., Al‐Saleem, T., & Cairns, P. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0597 · Cited by 229 · see citing works

The fundamental role of epigenetics in hematopoietic malignancies

Galm, O., Herman, J. G., & Baylin, S. B. (2005) · Blood Reviews · doi:10.1016/j.blre.2005.01.006 · Cited by 229 · see citing works

Two-dimensional transition metal dichalcogenide nanomaterials for biosensing applications

Hu, Y., Huang, Y., Tan, C., Zhang, X., Lu, Q., Sindoro, M., Huang, X. B., Huang, W., Wang, L., & Zhang, H. (2016) · Materials Chemistry Frontiers · doi:10.1039/c6qm00195e · Cited by 221 · see citing works

Versatile Fluorescence Resonance Energy Transfer-Based Mesoporous Silica Nanoparticles for Real-Time Monitoring of Drug Release

Lai, J., Shah, B. P., Garfunkel, E. L., & Lee, K. (2013) · ACS Nano · doi:10.1021/nn400199t · Cited by 211 · see citing works

PCR-Based Methods for Detecting Single-Locus DNA Methylation Biomarkers in Cancer Diagnostics, Prognostics, and Response to Treatment

Kristensen, L. S., & Hansen, L. L. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2008.121962 · Cited by 210 · see citing works

Correlation of BRAF Mutation Status in Circulating-Free DNA and Tumor and Association with Clinical Outcome across Four BRAFi and MEKi Clinical Trials

Santiago-Walker, A., Gagnon, R., Mazumdar, J., Casey, M., Long, G. V., Schadendorf, D., Flaherty, K. T., Kefford, R. F., Hauschild, A., Hwu, P., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-0321 · Cited by 209 · see citing works

Predicting Hepatocellular Carcinoma by Detection of Aberrant Promoter Methylation in Serum DNA

Zhang, Y., Wu, H., Shen, J., Ahsan, H., Tsai, W. Y., Yang, H., Wang, L., Chen, S., Chen, C., & Santella, R. M. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1900 · Cited by 192 · see citing works

Novel Methylation Biomarker Panel for the Early Detection of Pancreatic Cancer

Yi, J. M., Guzzetta, A. A., Bailey, V. J., Downing, S. R., Neste, L. V., Chiappinelli, K. B., Keeley, B. P., Stark, A., Herrera, A., Wolfgang, C. L., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-3224 · Cited by 188 · see citing works

Streptavidin‐Functionalized Silver‐Nanoparticle‐Enriched Carbon Nanotube Tag for Ultrasensitive Multiplexed Detection of Tumor Markers

Lai, G., Wu, J., Ju, H., & Yan, F. (2011) · Advanced Functional Materials · doi:10.1002/adfm.201100396 · Cited by 183 · see citing works

Silicon Nanowires for Biosensing, Energy Storage, and Conversion

Wang, Y., Wang, T., Da, P., Xu, M., Wu, H., & Zheng, G. (2013) · Advanced Materials · doi:10.1002/adma.201301943 · Cited by 175 · see citing works

Establishment of tumor‐specific copy number alterations from plasma DNA of patients with cancer

Heitzer, E., Auer, M., Hoffmann, E. M., Pichler, M., Gasch, C., Ulz, P., Lax, S., Waldispuehl‐Geigl, J., Mauermann, O., Mohan, S., et al. (2013) · International Journal of Cancer · doi:10.1002/ijc.28030 · Cited by 174 · see citing works

Microarray-Based Multiplexed Scanometric Immunoassay for Protein Cancer Markers Using Gold Nanoparticle Probes

Kim, D., Daniel, W. L., & Mirkin, C. A. (2009) · Analytical Chemistry · doi:10.1021/ac9018389 · Cited by 174 · see citing works

Biomarker-Driven Early Clinical Trials in Oncology

Tan, D. S. W., THOMAS, G. V., Garrett, M. D., Banerji, U., Bono, J. S. D., Kaye, S. B., & Workman, P. (2009) · The Cancer Journal · doi:10.1097/ppo.0b013e3181bd0445 · Cited by 171 · see citing works

PGP9.5 Promoter Methylation Is an Independent Prognostic Factor for Esophageal Squamous Cell Carcinoma

Mandelker, D. L., Yamashita, K., Tokumaru, Y., Mimori, K., Howard, D. L., Tanaka, Y., Carvalho, A. L., Jiang, W.-W., Park, H. L., Kim, M. S., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3923 · Cited by 167 · see citing works

Predictive Utility of Circulating Methylated DNA in Serum of Melanoma Patients Receiving Biochemotherapy

Mori, T., O'Day, S. J., Umetani, N., Martinez, S. R., Kitago, M., Koyanagi, K., Kuo, C. T., Takeshima, T., Milford, R., Wang, H.-J., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.02.9876 · Cited by 165 · see citing works

Cancers of the Oral Cavity and Pharynx

Mayne, S. T., Morse, D. E., & Winn, D. M. (2006) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195149616.003.0035 · Cited by 163 · see citing works

Identification of Tumor-associated Autoantigens for the Diagnosis of Colorectal Cancer in Serum Using High Density Protein Microarrays

Babel, I., Barderas, R., Díaz‐Uriarte, R., Martinez-Torrecuadrada, J. L., Sänchez‐Carbayo, M., & Casal, J. I. (2009) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m800596-mcp200 · Cited by 162 · see citing works

Molecular Detection of Prostate Cancer: A Role for GSTP1 Hypermethylation

Henrique, R., & Jerónimo, C. (2004) · European Urology · doi:10.1016/j.eururo.2004.06.014 · Cited by 162 · see citing works

Serum levels of interleukin-6 in patients with primary head and neck squamous cell carcinoma.

Riedel, F., Zaiss, I., Herzog, D., Götte, K., Naim, R., & Hörmann, K. (2005) · PubMed · Cited by 162 · see citing works

Serum Circulating Human mRNA Profiling and Its Utility for Oral Cancer Detection

Li, Y., Elashoff, D. A., Oh, M., Sinha, U. K., John, M. A. R. S., Zhou, X. C., Abemayor, E., & Wong, D. T. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.03.7598 · Cited by 160 · see citing works

DNA methylation and microRNA biomarkers for noninvasive detection of gastric and colorectal cancer

Toiyama, Y., Okugawa, Y., & Goel, A. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.08.001 · Cited by 157 · see citing works

Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma

Jiang, Z., Li, X., Jin, H., Zhou, W., Jiang, Y., Li, G., & Lu, D. (2006) · Neuroscience Research · doi:10.1016/j.neures.2006.09.006 · Cited by 155 · see citing works

Aberrant methylation of secreted frizzled‐related protein genes in esophageal adenocarcinoma and Barrett's esophagus

Zou, H., Molina, J. R., Harrington, J. J., Osborn, N. K., Klatt, K. K., Romero, Y., Burgart, L. J., & Ahlquist, D. A. (2005) · International Journal of Cancer · doi:10.1002/ijc.21045 · Cited by 154 · see citing works

Chemoprevention of hepatocellular carcinoma in aflatoxin endemic areas

Kensler, T. W., Egner, P. A., Wang, J.-B., Zhu, Y.-R., Zhang, B.-C., Lu, P., Chen, J., Qian, G.-S., Kuang, S.-Y., Jackson, P. E., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.09.046 · Cited by 153 · see citing works

Epigenetic inactivation of RAS association domain family protein 1 (RASSF1A) in malignant cutaneous melanoma.

Spugnardi, M., Tommasi, S., Dammann, R., Pfeifer, G. P., & Hoon, D. S. �. (2003) · PubMed · Cited by 153 · see citing works

Single-Wall Carbon Nanotube Forest Arrays for Immunoelectrochemical Measurement of Four Protein Biomarkers for Prostate Cancer

Chikkaveeraiah, B. V., Bhirde, A. A., Malhotra, R., Patel, V., Gutkind, J. S., & Rusling, J. F. (2009) · Analytical Chemistry · doi:10.1021/ac9018022 · Cited by 151 · see citing works

Magnetic nanochain integrated microfluidic biochips

Xiong, Q., Lim, C. Y., Ren, J., Zhou, J., Pu, K., Chan‐Park, M. B. E., Mao, H. Z., Lam, Y. C., & Duan, H. (2018) · Nature Communications · doi:10.1038/s41467-018-04172-1 · Cited by 151 · see citing works

Controlled Trapping and Release of Quantum Dots in a DNA‐Switchable Hydrogel

Liedl, T., Dietz, H., Yurke, B., & Simmel, F. C. (2007) · Small · doi:10.1002/smll.200700366 · Cited by 150 · see citing works

Cancer Prevention: From 1727 to Milestones of the Past 100 Years

Lippman, S. M., & Hawk, E. T. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1750 · Cited by 148 · see citing works

Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling

Beck, A. H., Lee, C.-H., Witten, D., Gleason, B., Edris, B., Espinosa, Í., Zhu, S., Li, R., Montgomery, K. D., Marinelli, R. J., et al. (2009) · Oncogene · doi:10.1038/onc.2009.381 · Cited by 147 · see citing works

Minireview: Epigenetic Alterations in Human Prostate Cancers

Nelson, W. G., Marzo, A. M. D., & Yegnasubramanian, S. (2009) · Endocrinology · doi:10.1210/en.2009-0573 · Cited by 143 · see citing works

Inverse Correlation between Cyclin A1 Hypermethylation and p53 Mutation in Head and Neck Cancer Identified by Reversal of Epigenetic Silencing

Tokumaru, Y., Yamashita, K., Osada, M., Nomoto, S., Sun, D., Xiao, Y., Hoque, M. O., Westra, W. H., Califano, J. A., & Sidransky, D. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0993 · Cited by 142 · see citing works

CpG island methylation in gastroenterologic neoplasia: A maturing field

Rashid, A., & Issa, J. J. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.09.007 · Cited by 142 · see citing works

Dual targeting of epigenetic therapy in cancer

Hellebrekers, D. M. E. I., Griffioen, A. W., & van Engeland, M. (2006) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2006.07.003 · Cited by 141 · see citing works

Circulating Nucleosomes Predict the Response to Chemotherapy in Patients with Advanced Non–Small Cell Lung Cancer

Holdenrieder, S., Stieber, P., von Pawel, J., Raith, H., Nagel, D., Feldmann, K., & Seidel, D. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0625 · Cited by 140 · see citing works

Raman spectroscopy of serum: an exploratory study for detection of oral cancers

Sahu, A., Sawant, S., Mamgain, H., & Krishna, C. M. (2013) · The Analyst · doi:10.1039/c3an00308f · Cited by 135 · see citing works

Epigenetic regulation of gene expression in cancer: techniques, resources and analysis

Kagohara, L. T., Stein-O’Brien, G., Kelley, D. Z., Flam, E. L., Wick, H. C., Danilova, L., Easwaran, H., Favorov, A. V., Qian, J. X., Gaykalova, D. A., et al. (2017) · Briefings in Functional Genomics · doi:10.1093/bfgp/elx018 · Cited by 135 · see citing works

Promoter Hypermethylation as an Independent Prognostic Factor for Relapse in Patients with Prostate Cancer Following Radical Prostatectomy

Rosenbaum, E., Hoque, M. O., Cohen, Y., ZAHURAK, M. L., Eisenberger, M. A., Epstein, J. I., Partin, A. W., & Sidransky, D. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1183 · Cited by 134 · see citing works

Epigenetic Changes in Solid and Hematopoietic Tumors

Toyota, M., & Issa, J. J. (2005) · Seminars in Oncology · doi:10.1053/j.seminoncol.2005.07.003 · Cited by 133 · see citing works

A Quantitative Proteomic Approach of the Different Stages of Colorectal Cancer Establishes OLFM4 as a New Nonmetastatic Tumor Marker

Besson, D., Pavageau, A.-H., Valo, I., Bourreau, A., Bélanger, A., Eymerit-Morin, C., Moulière, A., Chassevent, A., Boisdron-Celle, M., Morel, A., et al. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.009712 · Cited by 128 · see citing works

Abnormal DNA methylation, epigenetics, and prostate cancer

William, G. N. (2007) · Frontiers in bioscience · doi:10.2741/2385 · Cited by 128 · see citing works

TP53 and progression from Barrett’s metaplasia to oesophageal adenocarcinoma in a UK population cohort

Murray, L. J., Sedo, A., Scott, M., McManus, D., Sloan, J. M., Hardie, L. J., Forman, D., & Wild, C. P. (2006) · Gut · doi:10.1136/gut.2005.083295 · Cited by 127 · see citing works

Vascular Endothelial Growth Factor Expression is Up-Regulated by EWS-ETS Oncoproteins and Sp1 and May Represent an Independent Predictor of Survival in Ewing’s Sarcoma

Fuchs, B., Inwards, C. Y., & Janknecht, R. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0038 · Cited by 124 · see citing works

Apoptotic markers in cancer

Holdenrieder, S., & Stieber, P. (2004) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2004.05.003 · Cited by 123 · see citing works

IRX1 hypomethylation promotes osteosarcoma metastasis via induction of CXCL14/NF-κB signaling

Lu, J., Song, G., Tang, Q., Zou, C., Han, F., Zhao, Z., Yong, B., Yin, J., Xu, H., Xie, X., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78437 · Cited by 122 · see citing works

High Histone Deacetylase 7 (HDAC7) Expression Is Significantly Associated with Adenocarcinomas of the Pancreas

Ouaïssi, M., Sielezneff, I., Silvestre, R., Sastre, B., Bernard, J., Simony-Lafontaine, J., Payan, M. J., Dahan, L., Pirró, N., Seitz, J. F., et al. (2008) · Annals of Surgical Oncology · doi:10.1245/s10434-008-9940-z · Cited by 122 · see citing works

Development of Natural Protein Microarrays for Diagnosing Cancer Based on an Antibody Response to Tumor Antigens

Qiu, J., Madoz‐Gúrpide, J., Misek, D. E., Kuick, R. D., Brenner, D. E., Michailidis, G. C., Haab, B. B., Omenn, G. S., & Hanash, S. (2004) · Journal of Proteome Research · doi:10.1021/pr049971u · Cited by 122 · see citing works

Discovery and Identification of α-Defensins as Low Abundant, Tumor-Derived Serum Markers in Colorectal Cancer

Melle, C., Ernst, G., Schimmel, B., Bleul, A., Thieme, H., Kaufmann, R., Mothes, H. K., Settmacher, U., Claussen, U., Kj, H., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.05.014 · Cited by 121 · see citing works

Proteome analysis of human liver tumor tissue by two‐dimensional gel electrophoresis and matrixassisted laser desorption/ionization‐mass spectrometry for identification of disease‐related proteins

Kim, J., Kim, S. H., Lee, S. U., Ha, G., Kang, D. G., Ha, N., Ahn, J. S., Cho, H. Y., Kang, S., Lee, Y., et al. (2002) · Electrophoresis · doi:10.1002/elps.200290032 · Cited by 117 · see citing works

Dynamics of mitochondrial heteroplasmy in three families investigated via a repeatable re-sequencing study

Goto, H., Dickins, B., Afgan, E., Paul, I. M., Taylor, J., Makova, K. D., & Nekrutenko, A. (2011) · Genome biology · doi:10.1186/gb-2011-12-6-r59 · Cited by 116 · see citing works

Cancer molecular markers: A guide to cancer detection and management

Nair, M., Sandhu, S. S., & Sharma, A. K. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.02.002 · Cited by 85 · see citing works

Nucleic acid based molecular markers in the diagnosis of cancer

Kumari, A., & Kumar, V. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-22300-6.00048-6

Cancer Diagnosis with Molecular Markers

Sahoo, S. (2020) · doi:10.37421/mbl.2020.09.255

Molecular markers for cancer prognosis and treatment: Have we struck gold?

Nowsheen, S., Aziz, K., Panayiotidis, M. I., & Georgakilas, A. G. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.11.022 · Cited by 41 · see citing works

Clinical Application of Genetic, Oncogenic, and Differentiation Markers of Cancer

Sell, S., & Garrett, C. T. (1995) · Humana Press eBooks · doi:10.1007/978-1-4757-2381-6_1