The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Origins and consequences of centrosome aberrations in human cancers
Abstract
Recent years have seen a revival of interest in the possible contribution of centrosomes to the development of human cancers. The underlying hypothesis, formulated almost 100 years ago (Boveri T. The origin of malignant tumors; Baltimore, MD: Williams and Wilkins, 1929.), states that numerical and/or structural centrosome abnormalities will cause me missegregation. In addition, centrosome abnormalities are expected to affect cell shape, polarity, and motility. Thus, deregulation of centrosome number and function may foster both chromosomal instability and loss of tissue architecture—2 of the most common phenotypes associated with solid human tumors. In support of the role of centrosome deregulation in tumorigenesis, centrosome aberrations have been observed in early, premalignant lesions. Moreover, they are frequent in many different types of common tumors and their prominence often correlates with poor clinical outcome. This review addresses the origins of centrosome aberrations in human tumors as well as the expected impact of centrosome aberrations on cell fate and tumor development. © 2006 Wiley‐Liss, Inc.
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Cites
Proteomic characterization of the human centrosome by protein correlation profiling
Andersen, J. S., Wilkinson, C. J., Mayor, T., Mortensen, P., Nigg, E. A., & Mann, M. (2003) · Nature · doi:10.1038/nature02166 · Cited by 1,319
Self-citationBlangy, A., Lane, H. A., d'Hérin, P., Harper, M., Kress, M., & Niggt, E. A. (1995) · Cell · doi:10.1016/0092-8674(95)90142-6 · Cited by 952
Opposing motor activities are required for the organization of the mammalian mitotic spindle pole.
Gaglio, T., Saredi, A., Bingham, J. B., Hasbani, M. J., Gill, S. R., Schroer, T. A., & Compton, D. A. (1996) · The Journal of cell biology · doi:10.1083/jcb.135.2.399 · Cited by 290
Cited by
Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis
Holland, A. J., & Cleveland, D. W. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2718 · Cited by 859
Centrosome Amplification Can Initiate Tumorigenesis in Flies
Basto, R., Brunk, K., Vinadogrova, T., Peel, N., Franz, A., Khodjakov, A., & Raff, J. W. (2008) · Cell · doi:10.1016/j.cell.2008.05.039 · Cited by 560
Holland, A. J., & Cleveland, D. W. (2012) · EMBO reports · doi:10.1038/embor.2012.55 · Cited by 288
Human Papillomavirus Type 16 E7 Oncoprotein Associates with the Centrosomal Component γ-Tubulin
Nguyen, C. L., Eichwald, C., Nibert, M. L., & Münger, K. (2007) · Journal of Virology · doi:10.1128/jvi.01669-07 · Cited by 59
Structural insights into SSNA1 self-assembly and its microtubule binding for centriole maintenance
Agostini, L., Pfister, J. A., Basnet, N., Ding, J., Zhang, R., Biertümpfel, C., O’Connell, K. F., & Mizuno, N. (2025) · Nature Communications · doi:10.1038/s41467-025-62696-9 · Cited by 10
Metadata
- Authors
- Nigg, E. A.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2006-10-26
- Volume
- 119
- Issue
- 12
- Pages
- 2717-2723
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2060225984
- Cited by
- 223
- References
- 3
- FWCI
- 7.74
- Type
- journal article
- Language
- en
- Open access
- closed
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