Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis
Open accessAbstract
The mitotic checkpoint is a major cell cycle control mechanism that guards against chromosome missegregation and the subsequent production of aneuploid daughter cells. Most cancer cells are aneuploid and frequently missegregate chromosomes during mitosis. Indeed, aneuploidy is a common characteristic of tumours, and, for over 100 years, it has been proposed to drive tumour progression. However, recent evidence has revealed that although aneuploidy can increase the potential for cellular transformation, it also acts to antagonize tumorigenesis in certain genetic contexts. A clearer understanding of the tumour suppressive function of aneuploidy might reveal new avenues for anticancer therapy.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Chromosome missegregation can also be an inhibitor of tumorigenesis.
“However, there is now an expanding body of evidence suggesting that chromosome missegregation can also be an inhibitor of tumorigenesis56585960.”
From Mitotic Spindle Disruption by Alternating Electric Fields Leads to Improper Chromosome Segregation and Mitotic Catastrophe in Cancer Cells (2015) · cites this paper as [56]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The spindle-assembly checkpoint in space and time
Musacchio, A., & Salmon, E. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2163 · Cited by 2,227 · see citing works
Genetic instability in colorectal cancers
Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/386623a0 · Cited by 1,995 · see citing works
Mutations of mitotic checkpoint genes in human cancers
Cahill, D. P., Christoph Lengauer, C., Yu, J., Riggins, G. J., Willson, J. K. V., Markowitz, S. D., Kinzler, K. W., & Vogelstein, B. (1998) · Nature · doi:10.1038/32688 · Cited by 1,485 · see citing works
A mechanism linking extra centrosomes to chromosomal instability
Ganem, N. J., Godinho, S. A., & Pellman, D. S. (2009) · Nature · doi:10.1038/nature08136 · Cited by 1,427 · see citing works
On the road to cancer: aneuploidy and the mitotic checkpoint
Kops, G. J. P. L., Weaver, B. A. A., & Cleveland, D. W. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1714 · Cited by 1,188 · see citing works
Self-citationFeedback control of mitosis in budding yeast
Li, R., & Murray, A. W. (1991) · Cell · doi:10.1016/0092-8674(81)90015-5 · Cited by 1,174 · see citing works
S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function
Hoyt, M. A., Totis, L., & Roberts, B. T. (1991) · Cell · doi:10.1016/0092-8674(81)90014-3 · Cited by 1,138 · see citing works
Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells
Fujiwara, T., Bandi, M., Nitta, M., Ivanova, E. V., Bronson, R. T., & Pellman, D. (2005) · Nature · doi:10.1038/nature04217 · Cited by 1,067 · see citing works
Effects of Aneuploidy on Cellular Physiology and Cell Division in Haploid Yeast
Torres, E. M., Sokolsky, T., Tucker, C. M., Chan, L. Y., Boselli, M., Dunham, M. J., & Amon, A. (2007) · Science · doi:10.1126/science.1142210 · Cited by 935 · see citing works
Risks of leukaemia and solid tumours in individuals with Down's syndrome
Hasle, H., Clemmensen, I. H., & Mikkelsen, M. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05264-2 · Cited by 898 · see citing works
Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study
Yang, Q., Rasmussen, S. A., & Friedman, J. M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08092-3 · Cited by 847 · see citing works
Gascoigne, K. E., & Taylor, S. S. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.07.002 · Cited by 832 · see citing works
The Polo kinase Plk4 functions in centriole duplication
Habedanck, R., Stierhof, Y., Wilkinson, C. J., & Nigg, E. A. (2005) · Nature Cell Biology · doi:10.1038/ncb1320 · Cited by 809 · see citing works
Zur Frage der Entstehung maligner Tumoren
Boveri, T. (1914) · Cited by 789 · see citing works
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
Baker, D. J., Jeganathan, K. B., Cameron, J. D., Thompson, M., Juneja, S., Kopecka, A., Kumar, R., Jenkins, R. B., de Groen, P. C., Roche, P., et al. (2004) · Nature Genetics · doi:10.1038/ng1382 · Cited by 731 · see citing works
Aneuploidy Acts Both Oncogenically and as a Tumor Suppressor
Weaver, B. A. A., Silk, A. D., Montagna, C., Verdier-Pinard, P., & Cleveland, D. W. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.12.003 · Cited by 729 · see citing works
Self-citationMAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells
Michel, L. S., Liberal, V., Chatterjee, A., Kirchwegger, R., Pasche, B., Gerald, W. L., Dobles, M., Sorger, P. K., Murty, V. V. V. S., & Benezra, R. (2001) · Nature · doi:10.1038/35053094 · Cited by 725 · see citing works
Rieder, C. L., Cole, R. W., Khodjakov, A. L., & Sluder, G. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.130.4.941 · Cited by 715 · see citing works
Basto, R., Lau, J., Vinogradova, T. M., Gardiol, A., Woods, C. G., Khodjakov, A. L., & Raff, J. W. (2006) · Cell · doi:10.1016/j.cell.2006.05.025 · Cited by 686 · see citing works
Tetraploidy, aneuploidy and cancer
Ganem, N. J., Storchova, Z., & Pellman, D. (2007) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2007.02.011 · Cited by 668 · see citing works
Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells
Williams, B. R., Prabhu, V. R., Hunter, K. E., Glazier, C. M., Whittaker, C. A., Housman, D. E., & Amon, A. (2008) · Science · doi:10.1126/science.1160058 · Cited by 665 · see citing works
Meraldi, P., Honda, R., & Nigg, E. A. (2002) · The EMBO Journal · doi:10.1093/emboj/21.4.483 · Cited by 659 · see citing works
Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomesPreprint
Kwon, M., Godinho, S. A., Chandhok, N. S., Ganem, N. J., Azioune, A., Théry, M., & Pellman, D. S. (2008) · Genes & Development · doi:10.1101/gad.1700908 · Cited by 654 · see citing works
Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B
Hanks, S., Coleman, K., Reid, S., Plaja, A., Firth, H., Fitzpatrick, D., Kidd, A., Méhes, K., Nash, R., Robin, N. H., et al. (2004) · Nature Genetics · doi:10.1038/ng1449 · Cited by 627 · see citing works
Mad2 Overexpression Promotes Aneuploidy and Tumorigenesis in Mice
Sotillo, R., Hernando, E., Díaz-Rodríguez, E., Teruya-Feldstein, J., Cordón-Cardo, C., Lowe, S. W., & Benezra, R. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.10.019 · Cited by 612 · see citing works
Aurora B-Mediated Abscission Checkpoint Protects against Tetraploidization
Steigemann, P., Wurzenberger, C., Schmitz, M. H. A., Held, M., Guizetti, J., Maar, S., & Gerlich, D. W. (2009) · Cell · doi:10.1016/j.cell.2008.12.020 · Cited by 610 · see citing works
Centrosome amplification drives chromosomal instability in breast tumor development
Lingle, W. L., Barrett, S. L., Negron, V. C., D’Assoro, A. B., Boeneman, K., Liu, W., Whitehead, C. M., Reynolds, C. A., & Salisbury, J. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032479999 · Cited by 577 · see citing works
Cimini, D., Howell, B., Maddox, P., Khodjakov, A., Degrassi, F., & Salmon, E. D. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.3.517 · Cited by 568 · see citing works
Isolation and Characterization of a Pituitary Tumor-Transforming Gene (PTTG)
Pei, L., & Melmed, S. K. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.4.9911 · Cited by 567 · see citing works
Hernando, E., Nahlé, Z., Juan, G., Diaz-Rodriguez, E., Alaminos, M., Hemann, M., Michel, L., Mittal, V., Gerald, W., Benezra, R., et al. (2004) · Nature · doi:10.1038/nature02820 · Cited by 562 · see citing works
Centrosome Amplification Can Initiate Tumorigenesis in Flies
Basto, R., Brunk, K., Vinadogrova, T., Peel, N., Franz, A., Khodjakov, A. L., & Raff, J. W. (2008) · Cell · doi:10.1016/j.cell.2008.05.039 · Cited by 562 · see citing works
Weaver, B. A. A., & Cleveland, D. W. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.10.002 · Cited by 560 · see citing works
Self-citationChromosome Missegregation and Apoptosis in Mice Lacking the Mitotic Checkpoint Protein Mad2
Dobles, M., Liberal, V., Scott, M. L., Benezra, R., & Sorger, P. K. (2000) · Cell · doi:10.1016/s0092-8674(00)80875-2 · Cited by 525 · see citing works
Examining the link between chromosomal instability and aneuploidy in human cells
Thompson, S. L., & Compton, D. A. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200712029 · Cited by 521 · see citing works
Genome stability is ensured by temporal control of kinetochore–microtubule dynamics
Bakhoum, S. F., Thompson, S. L., Manning, A. L., & Compton, D. A. (2009) · Nature Cell Biology · doi:10.1038/ncb1809 · Cited by 453 · see citing works
Kops, G. J. P. L., Foltz, D. R., & Cleveland, D. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401142101 · Cited by 438 · see citing works
Self-citationChromatid cohesion defects may underlie chromosome instability in human colorectal cancers
Barber, T. D., McManus, K. J., Yuen, K. W. Y., Reis, M. M., Parmigiani, G., Shen, D., Barrett, I. J., Nouhi, Y., Spencer, F. A., Markowitz, S. D., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712384105 · Cited by 432 · see citing works
Spindle Multipolarity Is Prevented by Centrosomal Clustering
Quintyne, N. J., Reing, J. E., Hoffelder, D. R., Gollin, S. M., & Saunders, W. S. (2005) · Science · doi:10.1126/science.1104905 · Cited by 431 · see citing works
Aneuploidy: Cells Losing Their Balance
Torres, E. M., Williams, B. R., & Amon, A. (2008) · Genetics · doi:10.1534/genetics.108.090878 · Cited by 409 · see citing works
Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency
Baker, D. J., Perez-Terzic, C., Jin, F., Pitel, K. S., Niederländer, N. J., Jeganathan, K., Yamada, S., Reyes, S., Rowe, L., Hiddinga, H. J., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1744 · Cited by 408 · cited 1× · see citing works
“For example, reduced levels of BUBR1 promote an increase in lung tumours in mice that lack the p16 tumour suppresso”
BackgroundUeber asymmetrische Zelltheilung in Epithelkrebsen und deren biologische Bedeutung
Hansemann, D. (1890) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf01882039 · Cited by 406 · see citing works
Managing the centrosome numbers game: from chaos to stability in cancer cell division
Brinkley, B. R. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01872-9 · Cited by 402 · see citing works
Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines
Shi, Q., & King, R. W. (2005) · Nature · doi:10.1038/nature03958 · Cited by 396 · see citing works
Galipeau, P. C., Cowan, D., Sanchez, C. A., Barrett, M. T., Emond, M. J., Levine, D. S., Rabinovitch, P. S., & Reid, B. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.14.7081 · Cited by 360 · see citing works
Zur Frage der Entstehung maligner Tumoren
Ribbert, H., & Bally, W. (1914) · Die Naturwissenschaften · doi:10.1007/bf01497322 · Cited by 343 · see citing works
Babu, J. R., Jeganathan, K. B., Baker, D. J., Wu, X., Kang, N., & van Deursen, J. M. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211048 · Cited by 342 · see citing works
Unstable Kinetochore-Microtubule Capture and Chromosomal Instability Following Deletion of CENP-E
Putkey, F. R., Cramer, T., Morphew, M. K., Silk, A. D., Johnson, R. S., McIntosh, J. R., & Cleveland, D. W. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00255-1 · Cited by 331 · see citing works
Self-citationStructure, Expression, and Function of Human Pituitary Tumor-Transforming Gene (PTTG)
Zhang, X., Horwitz, G. A., Prezant, T. R., Valentini, A., Nakashima, M., Bronstein, M. D., & Melmed, S. K. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.1.0225 · Cited by 320 · see citing works
Abnormal Cytokinesis in Cells Deficient in the Breast Cancer Susceptibility Protein BRCA2
Daniels, M. J., Wang, Y., Lee, M.-Y., et al. (2004) · Science · doi:10.1126/science.1102574 · Cited by 319 · see citing works
Norden, C., Mendoza, M., Dobbelaere, J., Kotwaliwale, C. V., Biggins, S., & Barral, Y. (2006) · Cell · doi:10.1016/j.cell.2006.01.045 · Cited by 304 · see citing works
Slippage of Mitotic Arrest and Enhanced Tumor Development in Mice with BubR1 Haploinsufficiency
Dai, W. H., Wang, Q., Liu, T., Swamy, M. V., Fang, Y., Xie, S., Mahmood, R., Yang, Y., Xu, M., & Rao, C. V. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3119 · Cited by 291 · see citing works
Cimini, D., Moree, B., Canman, J. C., & Salmon, E. D. (2003) · Journal of Cell Science · doi:10.1242/jcs.00716 · Cited by 271 · see citing works
Weaver, B. A. A., Bonday, Z., Putkey, F. R., Kops, G. J. P. L., Silk, A. D., & Cleveland, D. W. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200303167 · Cited by 271 · see citing works
Self-citationTetraploidy and chromosomal instability are early events during cervical carcinogenesis
Olaharski, A. J., Sotelo, R., Solorza-Luna, G., Gonsebatt, M. E., Guzmán, P., Mohar, A., & Eastmond, D. A. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi218 · Cited by 264 · see citing works
Wang, X., Zhou, Y.-X., Qiao, W., Tominaga, Y., Ouchi, M., Ouchi, T., & Deng, C.-X. (2006) · Oncogene · doi:10.1038/sj.onc.1209707 · Cited by 262 · see citing works
Terminal phase of cytokinesis in D-98S cells
Mullins, J., & Biesele, J. (1977) · The Journal of Cell Biology · doi:10.1083/jcb.73.3.672 · Cited by 251 · see citing works
Kulukian, A., Han, J. S., & Cleveland, D. W. (2009) · Developmental Cell · doi:10.1016/j.devcel.2008.11.005 · Cited by 246 · see citing works
Self-citationPancreatic Neoplasia Induced by SV40 T-Antigen Expression in Acinar Cells of Transgenic Mice
Ornitz, D. M., Hammer, R. E., Messing, A., Palmiter, R. D., & Brinster, R. L. (1987) · Science · doi:10.1126/science.2821617 · Cited by 241 · see citing works
Kalitsis, P., Earle, E., Fowler, K. J., & Choo, K. H. A. (2000) · Genes & Development · doi:10.1101/gad.827500 · Cited by 241 · see citing works
Jeganathan, K. B., Malureanu, L. A., Baker, D., Abraham, S., & van Deursen, J. (2007) · Journal of Cell Biology · doi:10.1083/jcb.200706015 · Cited by 238 · see citing works
Origins and consequences of centrosome aberrations in human cancers
Nigg, E. A. (2006) · International Journal of Cancer · doi:10.1002/ijc.22245 · Cited by 223 · see citing works
Merotelic kinetochore orientation, aneuploidy, and cancer
Cimini, D. (2008) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2008.05.003 · Cited by 214 · see citing works
Aneuploidy: Instigator and Inhibitor of Tumorigenesis
Weaver, B. A. A., & Cleveland, D. W. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2266 · Cited by 195 · see citing works
Self-citationIwanaga, Y., Chi, Y., Miyazato, A., Sheleg, S. V., Haller, K., Péloponèse, J., Li, Y., Ward, J. M., Benezra, R., & Jeang, K. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3326 · Cited by 190 · see citing works
Upender, M. B., Habermann, J. K., McShane, L. M., Korn, E. L., Barrett, J. C., Difilippantonio, M. J., & Ried, T. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0474 · Cited by 188 · see citing works
LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1
Yang, X., Yu, K.-P., Hao, Y., et al. (2004) · Nature Cell Biology · doi:10.1038/ncb1140 · Cited by 188 · see citing works
The Rae1–Nup98 complex prevents aneuploidy by inhibiting securin degradation
Jeganathan, K. B., Malureanu, L. A., & van Deursen, J. M. (2005) · Nature · doi:10.1038/nature04221 · Cited by 184 · see citing works
BUBR1 deficiency results in abnormal megakaryopoiesis
Wang, Q. (2003) · Blood · doi:10.1182/blood-2003-06-2158 · Cited by 183 · see citing works
Matsuura, S., Matsumoto, Y., Morishima, K., Izumi, H., Matsumoto, H., Ito, E., Tsutsui, K., Kobayashi, J., Tauchi, H., Kajiwara, Y., et al. (2006) · American Journal of Medical Genetics. Part A · doi:10.1002/ajmg.a.31069 · Cited by 179 · see citing works
Early aging–associated phenotypes in Bub3/Rae1 haploinsufficient mice
Baker, D. J., Jeganathan, K. B., Malureanu, L., Perez-Terzic, C., Terzic, A., & van Deursen, J. M. A. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200507081 · Cited by 175 · see citing works
Castellanos, E., Domínguez-Giménez, P., & González, C. (2008) · Current Biology · doi:10.1016/j.cub.2008.07.029 · Cited by 167 · see citing works
Overexpression of Separase induces aneuploidy and mammary tumorigenesis
Zhang, N., Ge, G., Meyer, R., Sethi, S., Basu, D., Pradhan, S., Zhao, Y.-J., Li, X., Cai, W., El‐Naggar, A. K., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801610105 · Cited by 166 · see citing works
APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in <i>Min</i> mice
Caldwell, C. M., Green, R. A., & Kaplan, K. B. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200703186 · Cited by 164 · see citing works
Cimini, D., Fioravanti, D., Salmon, E. D., & Degrassi, F. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.3.507 · Cited by 162 · see citing works
Rao, C. V., Yang, Y., Swamy, M. V., Liu, T., Fang, Y., Mahmood, R., Jhanwar‐Uniyal, M., & Dai, W. H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407822102 · Cited by 160 · see citing works
Trisomy represses ApcMin -mediated tumours in mouse models of Down’s syndrome
Sussan, T. E., Yang, A., Li, F., et al. (2008) · Nature · doi:10.1038/nature06446 · Cited by 160 · see citing works
A Virus Causes Cancer by Inducing Massive Chromosomal Instability through Cell Fusion
Duelli, D. M., Padilla‐Nash, H. M., Berman, D. M., Murphy, K. M., Ried, T., & Lazebnik, Y. A. (2007) · Current Biology · doi:10.1016/j.cub.2007.01.049 · Cited by 157 · see citing works
Zhang, D., Hirota, T., Marumoto, T., Shimizu, M., Kunitoku, N., Sasayama, T., Arima, Y., Feng, L., Suzuki, M., Takeya, M., et al. (2004) · Oncogene · doi:10.1038/sj.onc.1208153 · Cited by 147 · see citing works
Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo
Dı́az-Rodrı́guez, E., Sotillo, R., Schvartzman, J. M., & Benezra, R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803504105 · Cited by 145 · see citing works
A mechanism for chromosome segregation sensing by the NoCut checkpoint
Mendoza, M., Norden, C., Durrer, K., Rauter, H., Uhlmann, F., & Barral, Y. (2009) · Nature Cell Biology · doi:10.1038/ncb1855 · Cited by 145 · see citing works
Hayama, S., Daigo, Y., Kato, T., Ishikawa, N., Yamabuki, T., Miyamoto, M., Ito, T., Tsuchiya, E., Kondo, S., & Nakamura, Y. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2137 · Cited by 144 · see citing works
Extra centrosomes and/or chromosomes prolong mitosis in human cells
Yang, Z., Lončarek, J., Khodjakov, A. L., & Rieder, C. L. (2008) · Nature Cell Biology · doi:10.1038/ncb1738 · Cited by 143 · see citing works
Flies without a spindle checkpoint
Buffin, E., Emré, D., & Karess, R. E. (2007) · Nature Cell Biology · doi:10.1038/ncb1570 · Cited by 142 · see citing works
Components of the spindle-assembly checkpoint are essential in Caenorhabditis elegans
Kitagawa, R., & Rose, A. M. (1999) · Nature Cell Biology · doi:10.1038/70309 · Cited by 141 · see citing works
Bub1 Maintains Centromeric Cohesion by Activation of the Spindle Checkpoint
Perera, D., Tilston, V., Hopwood, J. A., Barchi, M., Boot-Handford, R., & Taylor, S. S. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.08.008 · Cited by 140 · see citing works
Overexpressed Pituitary Tumor-Transforming Gene Causes Aneuploidy in Live Human Cells
Yu, R., Lu, W., Chen, J., et al. (2003) · Endocrinology · doi:10.1210/en.2003-0305 · Cited by 136 · see citing works
Segal, D. J., & McCoy, E. E. (1974) · Journal of Cellular Physiology · doi:10.1002/jcp.1040830112 · Cited by 125 · see citing works
Pituitary Hypoplasia inPttg−/−Mice Is Protective forRb+/−Pituitary Tumorigenesis
Chesnokova, V., Kovács, K., Castro, A.-V., Zonis, S., & Melmed, S. K. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0137 · Cited by 122 · see citing works
sSgo1, a Major Splice Variant of Sgo1, Functions in Centriole Cohesion Where It Is Regulated by Plk1
Wang, X., Yang, Y., Duan, Q., et al. (2008) · Developmental Cell · doi:10.1016/j.devcel.2007.12.007 · Cited by 118 · see citing works
A primate virus generates transformed human cells by fusion
Duelli, D. M., Hearn, S., Myers, M. P., & Lazebnik, Y. A. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200507069 · Cited by 96 · see citing works
Péloponèse, J., Haller, K., Miyazato, A., & Jeang, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506659103 · Cited by 88 · see citing works
Wang, X. X., Liu, R., Jin, S. Q., et al. (2006) · Cell Research · doi:10.1038/sj.cr.7310046 · Cited by 86 · see citing works
Increased chromosome instability but not cancer predisposition in haploinsufficient Bub3 mice
Kalitsis, P., Fowler, K. J., Griffiths, B., Earle, E., Chow, C. W., Jamsen, K. M., & Choo, K. H. A. (2005) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20215 · Cited by 76 · see citing works
Jeganathan, K. B., Baker, D., & van Deursen, J. (2006) · Cell Cycle · doi:10.4161/cc.5.4.2483 · Cited by 70 · see citing works
Mitotic Checkpoint Protein hsMAD2 as a Marker Predicting Liver Metastasis of Human Gastric Cancers
Tanaka, K., Nishioka, J., Kato, K., Nakamura, A., 毛利智美, Miki, C., Kusunoki, M., & Nobori, T. (2001) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.2001.tb01186.x · Cited by 56 · see citing works
Mad2 and p53 expression profiles in colorectal cancer and its clinical significance
Li, G. (2003) · World Journal of Gastroenterology · doi:10.3748/wjg.v9.i9.1972 · Cited by 56 · see citing works
Passos‐Bueno, M. R., Sertie, A. L., Richieri‐Costa, A., Alonso, L. G., Zatz, M., Alonso, N., Brunoni, D., & Ribeiro, S. F. M. (1998) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19980707)78:3 · Cited by 55 · see citing works
Nondisjunction, aneuploidy and tetraploidy
Weaver, B. A. A., Silk, A. D., & Cleveland, D. W. (2006) · Nature · doi:10.1038/nature05139 · Cited by 54 · see citing works
Self-citationSpindle assembly checkpoint and p53 deficiencies cooperate for tumorigenesis in mice
Chi, Y., Ward, J. M., Cheng, L., Yasunaga, J., & Jeang, K. (2008) · International Journal of Cancer · doi:10.1002/ijc.24094 · Cited by 45 · see citing works
Roh, M., Franco, O. E., Hayward, S. W., van der Meer, R., & Abdulkadir, S. A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002572 · Cited by 44 · see citing works
Studies on Down's syndrome in tissue culture
Segal, D. D. (1973) · Medical Entomology and Zoology · Cited by 32 · see citing works
Cytogenetic biomarkers for human cancer
Keen‐Kim, D. (2008) · Frontiers in bioscience · doi:10.2741/3127 · Cited by 23 · see citing works
張, 東. (2005) · Medical Entomology and Zoology · Cited by 13 · see citing works
Many faces of separase regulation.
Holland, A. J., & Taylor, S. S. (2008) · PubMed · Cited by 11 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Tumour heterogeneity and resistance to cancer therapies
Dagogo-Jack, I., & Shaw, A. T. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.166 · Cited by 3,846 · see citing works
Liquid Biopsies: Genotyping Circulating Tumor DNA
Diaz, L. A., & Bardelli, A. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2012.45.2011 · Cited by 2,210 · see citing works
Mitotic catastrophe: a mechanism for avoiding genomic instability
Vitale, I., Galluzzi, L., Castedo, M., & Kroemer, G. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3115 · Cited by 834 · see citing works
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
Nakada, D., Saunders, T. L., & Morrison, S. J. (2010) · Nature · doi:10.1038/nature09571 · Cited by 524 · see citing works
Proliferation of aneuploid human cells is limited by a p53-dependent mechanism
Thompson, S. L., & Compton, D. A. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200905057 · Cited by 494 · see citing works
Giladi, M., Schneiderman, R. S., Voloshin, T., Porat, Y., Munster, M., Blat, R., Sherbo, S., Bomzon, Z., Urman, N., Itzhaki, A., et al. (2015) · Scientific Reports · doi:10.1038/srep18046 · Cited by 327 · see citing works
Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy
Chen, G., Bradford, W. D., Seidel, C. W., & Li, R. (2012) · Nature · doi:10.1038/nature10795 · Cited by 274 · see citing works
The ATM–p53 pathway suppresses aneuploidy-induced tumorigenesis
Li, M., Fang, X., Baker, D. J., Guo, L., Gao, X., Wei, Z., Han, S., van Deursen, J. M., & Zhang, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005960107 · Cited by 257 · see citing works
Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E
Kim, Y., Holland, A. J., Lan, W., & Cleveland, D. W. (2010) · Cell · doi:10.1016/j.cell.2010.06.039 · Cited by 233 · see citing works
Self-citationA non-genetic route to aneuploidy in human cancers
Krajcovic, M., Johnson, N. B., Sun, Q., Normand, G., Hoover, N., Yao, E., Richardson, A. L., King, R. W., Cibas, E. S., Schnitt, S. J., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2174 · Cited by 188 · see citing works
Illicit survival of cancer cells during polyploidization and depolyploidization
Vitale, I., Galluzzi, L., Senovilla, L., Criollo, A., Jemaà, M., Castedo, M., & Kroemer, G. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2010.145 · Cited by 159 · see citing works
Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos
Vitale, I., Senovilla, L., Jemaà, M., Michaud, M., Galluzzi, L., Kepp, O., Nanty, L., Criollo, A., Rello‐Varona, S., Manic, G., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.11 · Cited by 146 · see citing works
Mitotic catastrophe and cancer drug resistance: A link that must to be broken
Denisenko, T. V., Sorokina, I. V., Gogvadze, V., & Zhivotovsky, B. (2016) · Drug Resistance Updates · doi:10.1016/j.drup.2015.11.002 · Cited by 108 · see citing works
Integrating the DNA damage and protein stress responses during cancer development and treatment
Gorgoulis, V. G., Pefani, D., Pateras, I. S., & Trougakos, I. P. (2018) · The Journal of Pathology · doi:10.1002/path.5097 · Cited by 108 · see citing works
Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability
Dorstyn, L., Puccini, J., Wilson, C. H., Shalini, S., Nicola, M., Moore, S., & Kumar, S. (2012) · Cell Death & Differentiation · doi:10.1038/cdd.2012.36 · Cited by 104 · see citing works
Birts, C. N., Nijjar, S. K., Mardle, C. A., Hoakwie, F., Duriez, P. J., Blaydes, J. P., & Tavassoli, A. (2013) · Chemical Science · doi:10.1039/c3sc50481f · Cited by 85 · see citing works
Caspase-2-mediated cell death is required for deleting aneuploid cells
Dawar, S., Lim, Y., Puccini, J., White, M., Thomas, P., Bouchier-Hayes, L., Green, D. R., Dorstyn, L., & Kumar, S. (2017) · Oncogene · doi:10.1038/onc.2016.423 · Cited by 66 · see citing works
Genomics and the Immune Landscape of Osteosarcoma
Wu, C.-C., & Livingston, J. A. (2020) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-030-43085-6_2 · Cited by 58 · see citing works
The mTOR pathway negatively controls ATM by up-regulating miRNAs
Shen, C., & Houghton, P. J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220898110 · Cited by 50 · see citing works
- Authors
- Holland, A. J., & Cleveland, D. W.
- Affiliations
- University of California San Diego (US)
- Ludwig Cancer Research (BE)
- Corresponding author
- Cleveland, Don W.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2009-07
- Volume
- 10
- Issue
- 7
- Pages
- 478-487
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- PMC
- PMC3154738
- OpenAlex
- W2062214822
- Cited by
- 859
- References
- 104
- Citations by year
- 2026: 9 · 2025: 31 · 2024: 42 · 2023: 47 · 2022: 34 · 2021: 43 · 2020: 40 · 2019: 42 · 2018: 47 · 2017: 51 · 2016: 45 · 2015: 71 · 2014: 56 · 2013: 65 · 2012: 85
- FWCI
- 5.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- European Molecular Biology Organization
- Ludwig Institute for Cancer Research
- National Institute of General Medical Sciences (R01GM029513)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Keywords
- aneuploidy, chromosomal instability, carcinogenesis, spindle assembly checkpoint, chromosome missegregation, tumor progression, cell cycle regulation, cancer therapy
- MeSH terms
- Aneuploidy, Animals, Cell Transformation, Neoplastic, Humans, Neoplasms, Polyploidy, Chromosomal Instability
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
