The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
DNA methylation of microRNA genes in gastric mucosae of gastric cancer patients: Its possible involvement in the formation of epigenetic field defect
Open accessAbstract
Accumulation of aberrant DNA methylation in normal‐appearing gastric mucosae, mostly induced by H. pylori infection, is now known to be deeply involved in predisposition to gastric cancers (epigenetic field defect), and silencing of protein‐coding genes has been analyzed so far. In this study, we aimed to clarify the involvement of microRNA (miRNA) gene silencing in the field defect. First, we selected three miRNA genes as methylation‐silenced after analysis of six candidate “methylation‐silenced” tumor‐suppressor miRNA genes. Methylation levels of the three genes (miR‐124a‐1, miR‐124a‐2 and miR‐124a‐3) were quantified in 56 normal gastric mucosae of healthy volunteers (28 volunteers with H. pylori and 28 without), 45 noncancerous gastric mucosae of gastric cancer patients (29 patients with H. pylori and 16 without), and 28 gastric cancer tissues (13 intestinal and 15 diffuse types). Among the healthy volunteers, individuals with H. pylori had 7.8–13.1‐fold higher methylation levels than those without (p < 0.001). Among individuals without H. pylori, noncancerous gastric mucosae of gastric cancer patients had 7.2–15.5‐fold higher methylation levels than gastric mucosae of healthy volunteers (p < 0.005). Different from protein‐coding genes, individuals with past H. pylori infection retained similar methylation levels to those with current infection. In cancer tissues, methylation levels were highly variable, and no difference was observed between intestinal and diffuse histological types. This strongly indicated that methylation‐silencing of miRNA genes, in addition to that of protein‐coding genes, contributed to the formation of a field defect for gastric cancers. © 2008 Wiley‐Liss, Inc.
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MicroRNA signatures in human cancers
Calin, G. A., & Croce, C. M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1997 · Cited by 7,590
LAURÉN, P. (1965) · Acta Pathologica Microbiologica Scandinavica · doi:10.1111/apm.1965.64.1.31 · Cited by 6,133
Oncomirs—MicroRNAs with a role in cancer
Esquela-Kerscher, A., & Slack, F. J. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1840 · Cited by 5,884
Helicobacter pylori Infection and the Development of Gastric Cancer
Uemura, N., Okamoto, S., Yamamoto, S., Matsumura, N., Yamaguchi, S., Yamakido, M., Taniyama, K., Sasaki, N., & Schlemper, R. J. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa001999 · Cited by 4,465
The Role of Chromatin during Transcription
Li, B., Carey, M., & Workman, J. L. (2007) · Cell · doi:10.1016/j.cell.2007.01.015 · Cited by 3,533
Japanese Classification of Gastric Carcinoma – 2nd English Edition –
Japanese Gastric Cancer Association (1998) · Gastric Cancer · doi:10.1007/pl00011681 · Cited by 2,170
Weisenberger, D. J., Siegmund, K. D., Campan, M., Young, J., Long, T. I., Faasse, M. A., Kang, G. H., Widschwendter, M., Weener, D., Buchanan, D., et al. (2006) · Nature Genetics · doi:10.1038/ng1834 · Cited by 1,990
Saito, Y., Liang, G., Egger, G., Friedman, J. M., Chuang, J. C., Coetzee, G. A., & Jones, P. A. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.04.020 · Cited by 1,335
Braakhuis, B. J. M., Tabor, M. P., Kummer, J. A., Leemans, C. R., & Brakenhoff, R. H. (2003) · PubMed · Cited by 1,208
Genetic Unmasking of an Epigenetically Silenced microRNA in Human Cancer Cells
Lujambio, A., Ropero, S., Ballestar, E., Fraga, M. F., Cerrato, C., Setién, F., Casado, S., Suarez-Gauthier, A., Sanchez-Cespedes, M., Gitt, A., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4218 · Cited by 939
Cited by
Interplay between microRNAs and the epigenetic machinery: An intricate network
Iorio, M. V., Piovan, C., & Croce, C. M. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2010.05.005 · Cited by 306
MicroRNAs in tumorigenesis, metastasis, diagnosis and prognosis of gastric cancer
Jiang, C., Chen, X., Alattar, M., Wei, J., & Liu, H. (2015) · Cancer Gene Therapy · doi:10.1038/cgt.2015.19 · Cited by 111
MicroRNA-124 promotes hepatic triglyceride accumulation through targeting tribbles homolog 3
Liu, X., Zhao, J., Liu, Q., Xiong, X., Zhang, Z., Jiao, Y., Li, X., Liu, B., Li, Y., & Lu, Y. (2016) · Scientific Reports · doi:10.1038/srep37170 · Cited by 25
Metadata
- Authors
- Ando, T., Yoshida, T., Enomoto, S., Asada, K., Tatematsu, M., Ichinose, M., Sugiyama, T., & Ushijima, T.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2009-03-16
- Volume
- 124
- Issue
- 10
- Pages
- 2367-2374
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W1987374056
- Cited by
- 279
- References
- 33
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ando, T., Yoshida, T., Enomoto, S., Asada, K., Tatematsu, M., Ichinose, M., Sugiyama, T., & Ushijima, T. (2009). DNA methylation of microRNA genes in gastric mucosae of gastric cancer patients: Its possible involvement in the formation of epigenetic field defect. International Journal of Cancer. https://doi.org/10.1002/ijc.24219
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