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Cited by 720

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: An epidemic of viral‐induced carcinoma?

Näsman, Anders, Attner, Per, Hammarstedt, Lalle, Du, Juan, Eriksson, Mathilda, Giraud, Geraldine, Ährlund‐Richter, Sofie, Marklund, Linda, Romanitan, Mircea, Lindquist, David, Ramqvist, Torbjörn, Lindholm, Johan, Sparén, Pär, Ye, Weimin, Dahlstrand, Hanna, Munck‐Wikland, Eva, Dalianis, Tina·2009·International Journal of Cancer
DOI 10.1002/ijc.24339
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Abstract

In the county of Stockholm, between 1970 and 2002, we have previously reported a 3‐fold parallel increase in the incidence of tonsillar squamous cell carcinoma (SCC) and the proportion of human papillomavirus (HPV) positive tonsillar SCC. Here, we have followed the above parameters in all patients ( n = 120) diagnosed with tonsillar SCC during 2003–2007 in the same area, and also in correlation to our previous data. Ninety‐eight pretreatment biopsies were available and presence of HPV DNA and HPV‐16 E6 and E7 RNA were tested by polymerase chain reaction (PCR) and RT‐PCR. Incidence data were obtained from the Swedish Cancer Registry. Data reported from 1970 to 2002 were also obtained for comparison. HPV DNA was present in 83 of 98 (85%) of the tonsillar SCC biopsies from 2003 to 2007 and 77 of these were HPV‐16 positive. HPV‐16 E6 and E7 RNA were found in 98% of 52 analyzed HPV‐16 positive cases. The proportion of HPV‐positive cancers had significantly increased both from 1970 to 2007 ( p < 0.0001) as well from 2000 to 2007 ( p < 0.01), with 68% (95% confidence interval (CI), 53–81) 2000–2002; 77% (95% CI, 63–87) 2003–2005; and 93% (95% CI, 82–99) 2006–2007. The incidence rate of HPV‐positive tumors almost doubled each decade between 1970 and 2007, in parallel with a decline of HPV‐negative tumors. In conclusion, the incidence of HPV‐positive cancers is still increasing in the County of Stockholm, suggesting an epidemic of a virus‐induced carcinoma, with soon practically all tonsillar SCC being HPV positive, as in cervical cancer. © 2009 UICC

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Metadata

Authors
Näsman, A., Attner, P., Hammarstedt, L., Du, J., Eriksson, M., Giraud, G., Ährlund‐Richter, S., Marklund, L., Romanitan, M., Lindquist, D., Ramqvist, T., Lindholm, J., Sparén, P., Ye, W., Dahlstrand, H., Munck‐Wikland, E., & Dalianis, T.
Venue
International Journal of Cancer
Publisher
Wiley
Published
2009-03-27
Volume
125
Issue
2
Pages
362-366
ISSN
  • 0020-7136 (ISSN-L)
  • 1097-0215
DOI
10.1002/ijc.24339
OpenAlex
W2041949509
Cited by
720
References
22
FWCI
51.62
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: An epidemic of viral‐induced carcinoma? https://app.cochat.ai/papers/10.1002/ijc.24339
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Näsman, A., Attner, P., Hammarstedt, L., Du, J., Eriksson, M., Giraud, G., Ährlund‐Richter, S., Marklund, L., Romanitan, M., Lindquist, D., Ramqvist, T., Lindholm, J., Sparén, P., Ye, W., Dahlstrand, H., Munck‐Wikland, E., & Dalianis, T. (2009). Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: An epidemic of viral‐induced carcinoma? International Journal of Cancer. https://doi.org/10.1002/ijc.24339

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.