The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Human Papillomavirus Infection as a Risk Factor for Squamous-Cell Carcinoma of the Head and Neck
Open accessAbstract
BACKGROUND: Oncogenic human papillomaviruses (HPVs), especially HPV type 16 (HPV-16), cause anogenital epithelial cancers and are suspected of causing epithelial cancers of the head and neck. METHODS: To examine the relation between head and neck cancers and HPVs, we performed a nested case-control study within a joint Nordic cohort in which serum samples were collected from almost 900,000 subjects. Samples collected at enrollment from 292 persons in whom squamous-cell carcinoma of the head and neck developed, on average, 9.4 years after enrollment and from 1568 matched controls were analyzed for antibodies against HPV-16, HPV-18, HPV-33, and HPV-73 and for cotinine levels as a marker of smoking habits. Polymerase-chain-reaction (PCR) analyses for HPV DNA were performed in tumor tissue from 160 of the study patients with cancer. RESULTS: After adjustment for cotinine levels, the odds ratio for squamous-cell carcinoma of the head and neck in subjects who were seropositive for HPV-16 was 2.2 (95 percent confidence interval, 1.4 to 3.4). No increased risk was observed for other HPV types. Fifty percent of oropharyngeal and 14 percent of tongue cancers contained HPV-16 DNA, according to PCR analysis. CONCLUSIONS: HPV-16 infection may be a risk factor for squamous-cell carcinoma of the head and neck.
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Cites
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Cited by
Variation in cancer risk among tissues can be explained by the number of stem cell divisions
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Molecular biology of squamous cell carcinoma of the head and neck
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The landscape of viral expression and host gene fusion and adaptation in human cancer
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Metadata
- Authors
- Mork, J., Lie, A. K., Glattre, E., Clark, S., Hallmans, G., Jellum, E., Koskela, P., Møller, B., Pukkala, E., Schiller, J. T., Wang, Z., Youngman, L., Lehtinen, M., & Dillner, J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2001-04-12
- Volume
- 344
- Issue
- 15
- Pages
- 1125-1131
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2342166036
- Cited by
- 939
- References
- 28
- FWCI
- 36.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Human Papillomavirus Infection as a Risk Factor for Squamous-Cell Carcinoma of the Head and Neck. https://app.cochat.ai/papers/10.1056/nejm200104123441503
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- Mork, J., Lie, A. K., Glattre, E., Clark, S., Hallmans, G., Jellum, E., Koskela, P., Møller, B., Pukkala, E., Schiller, J. T., Wang, Z., Youngman, L., Lehtinen, M., & Dillner, J. (2001). Human Papillomavirus Infection as a Risk Factor for Squamous-Cell Carcinoma of the Head and Neck. New England Journal of Medicine. https://doi.org/10.1056/nejm200104123441503
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
