The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Role of microRNA in anticancer drug resistance
Abstract
Chemotherapy has been widely used in treatment of cancer, both as systemic therapy and as part of local treatment. Unfortunately, many kinds of cancer are still refractory to chemotherapy. The anticancer drug resistance mechanisms have been extensively explored, yet have not been fully characterized. Recent works have underlined the involvement of noncoding RNAs in cancer development, with several studies regarding their possible involvement in the evolution of drug resistance. MicroRNAs (miRNAs) are endogenous small noncoding RNAs (20–23 nucleotides) that negatively regulate the gene expressions at the post‐transcriptional level by base pairing to the 3′ untranslated region of target messenger RNAs. Evidence is emerging that particular microRNAs (miRNA) alterations are involved in the initiation and progression of human cancer. More recently, accumulating evidence is revealing an important role of miRNAs in anticancer drug resistance and miRNA expression profiling can be correlated with the development of anticancer drug resistance. The micro‐RNA‐mediated form of drug resistance adds yet another mechanism of drug resistance. So, exploiting the emerging knowledge of miRNAs for the development of new human therapeutic applications for overcoming anticancer drug resistance will be important.
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Cites
Targeting multidrug resistance in cancer
Szakács, G., Paterson, J. K., Ludwig, J. A., Booth-Genthe, C., & Gottesman, M. M. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1984 · Cited by 3,609
Somatic mutations affect key pathways in lung adenocarcinoma
Ding, L., Getz, G., Wheeler, D. A., Mardis, E. R., McLellan, M. D., Cibulskis, K., Sougnez, C., Greulich, H., Muzny, D. M., Morgan, M. B., et al. (2008) · Nature · doi:10.1038/nature07423 · Cited by 2,681
Epigenetics as a mechanism driving polygenic clinical drug resistance
Glasspool, R. M., Teodoridis, J. M., & Brown, R. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603024 · Cited by 236
Cited by
MicroRNA regulation of core apoptosis pathways in cancer
Lima, R. T., Busacca, S., Almeida, G. M., Gaudino, G., Fennell, D. A., & Vasconcelos, M. H. (2011) · European Journal of Cancer · doi:10.1016/j.ejca.2010.11.005 · Cited by 260
miR-497 modulates multidrug resistance of human cancer cell lines by targeting BCL2
Zhu, W., Zhu, D., Lu, S., Wang, T., Wang, J., Jiang, B., Shu, Y., & Liu, P. (2012) · Medical Oncology · doi:10.1007/s12032-010-9797-4 · Cited by 189
Self-citationImproving Gemcitabine Sensitivity in Pancreatic Cancer Cells by Restoring miRNA-217 Levels
Panebianco, C., Trivieri, N., Villani, A., Terracciano, F., Latiano, T. P., Potenza, A., Perri, F., Binda, E., & Pazienza, V. (2021) · Biomolecules · doi:10.3390/biom11050639 · Cited by 26
MicroRNAs in B-cells: From normal differentiation to treatment of malignancies
Marques, S. C., Laursen, M. B., Bødker, J. S., Kjeldsen, M. K., Falgreen, S., Schmitz, A., Bøgsted, M., Johnsen, H. E., & Dybkaer, K. (2015) · Oncotarget · doi:10.18632/oncotarget.3057 · Cited by 26
Metadata
- Authors
- Zheng, T., Wang, J., Chen, X., & Liu, L.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2009-09
- Volume
- 126
- Issue
- 1
- Pages
- 2-10
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W1996880875
- Cited by
- 233
- References
- 3
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- closed
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