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Cited by 26MicroRNA in disease regulationLymphoma Diagnosis and TreatmentChronic Lymphocytic Leukemia Research

MicroRNAs in B-cells: From normal differentiation to treatment of malignancies

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Marques, Sara Correia, Laursen, Maria Bach, Bødker, Julie Støve, Kjeldsen, Malene Krag, Falgreen, Steffen, Schmitz, Alexander, Bøgsted, Martin, Johnsen, Hans Erik +1 more·2015·Oncotarget
DOI 10.18632/oncotarget.3057PMC PMC4381575
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Abstract

// Sara Correia Marques 1,2 , Maria Bach Laursen 1 , Julie Støve Bødker 1 , Malene Krag Kjeldsen 1 , Steffen Falgreen 1 , Alexander Schmitz 1 , Martin Bøgsted 1,3 , Hans Erik Johnsen 1,3,4 and Karen Dybkaer 1,3 1 Department of Haematology, Aalborg University Hospital, Aalborg, Denmark 2 Department of Clinical Medicine, Aarhus University, Denmark 3 Department of Clinical Medicine, Aalborg University, Denmark 4 Clinical Cancer Research Center, Aalborg University Hospital, Denmark Correspondence: Karen Dybkaer, email: // Keywords : MicroRNA, B-cell, Differentiation, B-cell malignancies, Drug response Received : September 16, 2014 Accepted : December 09, 2014 Published : December 10, 2014 Abstract MicroRNAs (miRNAs) are small non-coding RNAs that play important post-transcriptional regulatory roles in a wide range of biological processes. They are fundamental to the normal development of cells, and evidence suggests that the deregulation of specific miRNAs is involved in malignant transformation due to their function as oncogenes or tumor suppressors. We know that miRNAs are involved in the development of normal B-cells and that different B-cell subsets express specific miRNA profiles according to their degree of differentiation. B-cell-derived malignancies contain transcription signatures reminiscent of their cell of origin. Therefore, we believe that normal and malignant B-cells share features of regulatory networks controlling differentiation and the ability to respond to treatment. The involvement of miRNAs in these processes makes them good biomarker candidates. B-cell malignancies are highly prevalent, and the poor overall survival of patients with these malignancies demands an improvement in stratification according to prognosis and therapy response, wherein we believe miRNAs may be of great importance. We have critically reviewed the literature, and here we sum up the findings of miRNA studies in hematological cancers, from the development and progression of the disease to the response to treatment, with a particular emphasis on B-cell malignancies.

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  • Expression of microRNAs in macrophages can be dynamically regulated in response to different stimuli, such as antigen recognition by cell receptors, NF-κB activation and cytokine release.

    “Expression of microRNAs in macrophages can be dynamically regulated in response to different stimuli, such as antigen recognition by cell receptors, NF-κB activation and cytokine release [55,58,60].”

    From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [60]

    The Introduction’s B-cell differentiation section (page unavailable) reports that miRNA expression profiles differ across stages of B-cell differentiation, supporting the general idea that expression varies. It does not establish stimulus-driven regulation in macrophages or identify antigen recognition, NF-κB activation, or cytokine release as triggers. (LLM, conf=0.79)

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Cited by

Sorted by citations

Authors
Marques, S. C., Laursen, M. B., Bødker, J. S., Kjeldsen, M. K., Falgreen, S., Schmitz, A., Bøgsted, M., Johnsen, H. E., & Dybkaer, K.
Affiliations
  • Aarhus University (DK)
  • Aalborg University Hospital (DK)
  • Department of Haematology, Aalborg University Hospital, Aalborg, Denmark
ORCID
Venue
Oncotarget
Publisher
Impact Journals, LLC
Published
2014-12-10
Volume
6
Issue
1
Pages
7-25
ISSN
1949-2553 (ISSN-L)
DOI
10.18632/oncotarget.3057
PMC
PMC4381575
OpenAlex
W1878716376
Cited by
26
References
2
Citations by year
2023: 1 · 2022: 3 · 2021: 1 · 2020: 5 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 7
FWCI
0.36
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Oncotarget (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • VBN Forskningsportal (Aalborg Universitet) (submittedVersion, other-oa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
  • Health Sciences › Medicine › Genetics › Chronic Lymphocytic Leukemia Research
Keywords
microRNA, B cell differentiation, B-cell malignancies, post-transcriptional regulation, microRNA biomarkers, treatment response, cell of origin, hematologic cancer, prognosis
MeSH terms
B-Lymphocytes, Cell Differentiation, Cell Transformation, Neoplastic, Humans, Neoplasms, Oncogenes, Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, Genes, Tumor Suppressor, Treatment Outcome, Disease Progression, Drug Resistance, Neoplasm, Hematologic Neoplasms, MicroRNAs

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