The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Plasma microRNAs are promising novel biomarkers for early detection of colorectal cancer
Abstract
MicroRNA (miRNA) opens up a new field for molecular diagnosis of cancer. However, the role of circulating miRNAs in plasma/serum in cancer diagnosis is not clear. The aim of this study was to investigate whether plasma miRNAs can be used as biomarkers for the early detection of colorectal carcinoma (CRC). We measured the levels of 12 miRNAs (miR‐134, −146a, −17‐3p, −181d, −191, −221, −222, −223, −25, −29a, −320a and −92a) in plasma samples from patients with advanced colorectal neoplasia (carcinomas and advanced adenomas) and healthy controls using real‐time RT‐PCR. We found that plasma miR‐29a and miR‐92a have significant diagnostic value for advanced neoplasia. MiR‐29a yielded an AUC (the areas under the ROC curve) of 0.844 and miR‐92a yielded an AUC of 0.838 in discriminating CRC from controls. More importantly, these 2 miRNAs also could discriminate advanced adenomas from controls and yielded an AUC of 0.769 for miR‐29a and 0.749 for miR‐92a. Combined ROC analyses using these 2 miRNAs revealed an elevated AUC of 0.883 with 83.0% sensitivity and 84.7% specificity in discriminating CRC, and AUC of 0.773 with 73.0% sensitivity and 79.7% specificity in discriminating advanced adenomas. Collectively, these data suggest that plasma miR‐29a and miR‐92a have strong potential as novel noninvasive biomarkers for early detection of CRC.
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Cited by
The MicroRNA Spectrum in 12 Body Fluids
Weber, J. A., Baxter, D. H., Zhang, S., Huang, D. Y., How Huang, K., Jen Lee, M., Galas, D. J., & Wang, K. (2010) · Clinical Chemistry · doi:10.1373/clinchem.2010.147405 · Cited by 2,477
Self-citationBlood Cell Origin of Circulating MicroRNAs: A Cautionary Note for Cancer Biomarker Studies
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Epigenetics of colorectal cancer: biomarker and therapeutic potential
Jung, G., Hernández-Illán, E., Moreira, L., Balaguer, F., & Goel, A. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0230-y · Cited by 813
Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers
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Circulating Exosomal microRNAs as Biomarkers of Colon Cancer
Ogata-Kawata, H., Izumiya, M., Kurioka, D., Honma, Y., Yamada, Y., Furuta, K., Gunji, T., Ohta, H., Okamoto, H., Sonoda, H., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092921 · Cited by 809
Metadata
- Authors
- Huang, Z., Huang, D., Ni, S., Peng, Z., Sheng, W., & Du, X.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2010-04-21
- Volume
- 127
- Issue
- 1
- Pages
- 118-126
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2140245250
- Cited by
- 964
- References
- 37
- FWCI
- 19.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Huang, Z., Huang, D., Ni, S., Peng, Z., Sheng, W., & Du, X. (2010). Plasma microRNAs are promising novel biomarkers for early detection of colorectal cancer. International Journal of Cancer. https://doi.org/10.1002/ijc.25007
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