Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers
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A number of histone demethylases have been identified and biochemically characterized, but the pathological roles of their dysfunction in human disease like cancer have not been well understood. Here, we demonstrate important roles of lysine‐specific demethylase 1 (LSD1) in human carcinogenesis. Expression levels of LSD1 are significantly elevated in human bladder carcinomas compared with nonneoplastic bladder tissues (p < 0.0001). cDNA microarray analysis also revealed its transactivation in lung and colorectal carcinomas. LSD1‐specific small interfering RNAs significantly knocked down its expression and resulted in suppression of proliferation of various bladder and lung cancer cell lines. Concordantly, introduction of exogenous LSD1 expression promoted cell cycle progression of human embryonic kidney fibroblast cells. Expression profile analysis showed that LSD1 could affect the expression of genes involved in various chromatin‐modifying pathways such as chromatin remodeling at centromere, centromeric heterochromatin formation and chromatin assembly, indicating its essential roles in carcinogenesis through chromatin modification.
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LSD1 is highly expressed in AML patients and its overexpression has been correlated with impaired survival in various other tumours.
“LSD1 is highly expressed in AML patients (www.proteinatlas.org) and its overexpression has been correlated with impaired survival in various other tumours (Hayami et al, 2011).”
From Unlocking the potential of retinoic acid in anticancer therapy (2014) · cites this paper as Hayami et al, 2011
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- Authors
- Hayami, S., Kelly, J. D., Cho, H., Yoshimatsu, M., Unoki, M., Tsunoda, T., Field, H. I., Neal, D. E., Yamaue, H., Ponder, B. A. J., Nakamura, Y., & Hamamoto, R.
- Affiliations
- Wakayama Medical University (JP)
- University College London (GB)
- Institute of Medical Science, The University of Tokyo (JP)
- RIKEN (JP)
- University of Cambridge (GB)
- Corresponding author
- Nakamura, Yusuke
- ORCID
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2010-11-27
- Volume
- 128
- Issue
- 3
- Pages
- 574-586
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2090333443
- Cited by
- 489
- References
- 50
- Citations by year
- 2026: 15 · 2025: 13 · 2024: 28 · 2023: 27 · 2022: 24 · 2021: 32 · 2020: 30 · 2019: 30 · 2018: 38 · 2017: 34 · 2016: 39 · 2015: 44 · 2014: 38 · 2013: 43 · 2012: 36
- FWCI
- 12.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Cancer (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust (999998)
- Cancer Research UK (19275)
- Japan Society for the Promotion of Science
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- LSD1, histone demethylase, carcinogenesis, chromatin regulation, bladder cancer, lung cancer, colorectal cancer, cell proliferation, cell cycle progression, centromeric heterochromatin, chromatin remodeling, chromatin assembly, gene expression profiling
- MeSH terms
- Urinary Bladder, Urinary Bladder Neoplasms, Cell Cycle, Cell Division, Chromatin, DNA, Neoplasm, Humans, Immunohistochemistry, Neoplasms, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Polymerase Chain Reaction, DNA, Complementary, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Cell Line, Tumor, Histone Demethylases
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