Cited by 387Cancer-related gene regulationEpigenetics and DNA MethylationRNA modifications and cancer

Critical roles of non-histone protein lysine methylation in human tumorigenesis

Hamamoto, Ryuji, Saloura, Vassiliki, Nakamura, Yusuke·2015·Nature Reviews Cancer

Abstract

Several protein lysine methyltransferases and demethylases have been identified to have critical roles in histone modification. A large body of evidence has indicated that their dysregulation is involved in the development and progression of various diseases, including cancer, and these enzymes are now considered to be potential therapeutic targets. Although most studies have focused on histone methylation, many reports have revealed that these enzymes also regulate the methylation dynamics of non-histone proteins such as p53, RB1 and STAT3 (signal transducer and activator of transcription 3), which have important roles in human tumorigenesis. In this Review, we summarize the molecular functions of protein lysine methylation and its involvement in human cancer, with a particular focus on lysine methylation of non-histone proteins.

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Crossref · 10.1038/nrc3884

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  • The mechanisms that underpin adaptive responses and render epigenetic therapies ineffective are varied and include tumour-intrinsic mechanisms and heterogenous cellular and molecular effects of the drugs.

    “The mechanisms that underpin these adaptive responses and render epigenetic therapies ineffective are varied and include tumour-intrinsic mechanisms and heterogenous cellular and molecular effects of the drugs 187 .”

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Authors
Hamamoto, R., Saloura, V., & Nakamura, Y.
Affiliations
University of Chicago (US)
Corresponding author
Hamamoto, Ryuji
Venue
Nature Reviews Cancer
Published
2015-01-23
Volume
15
Issue
2
Pages
110-124
ISSN
  • 1474-175X (ISSN-L)
  • 1474-1768
OpenAlex
W2036357556
Cited by
376
References
167
Citations by year
2026: 14 · 2025: 20 · 2024: 27 · 2023: 29 · 2022: 36 · 2021: 30 · 2020: 39 · 2019: 38 · 2018: 33 · 2017: 38 · 2016: 49 · 2015: 22
FWCI
4.69
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Cancer (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
Keywords
carcinogenesis, p53, RB1, STAT3, lysine methyltransferase, demethylases, cancer therapy targets, histone modifications
MeSH terms
Cell Transformation, Neoplastic, Chromosomal Proteins, Non-Histone, Humans, Lysine, Methylation, Histone-Lysine N-Methyltransferase, Tumor Suppressor Protein p53, Retinoblastoma Protein, STAT3 Transcription Factor

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