Human papillomavirus types in 115,789 HPV‐positive women: A meta‐analysis from cervical infection to cancer
Open accessAbstract
Genotyping may improve risk stratification of high-risk (HR) human papillomavirus (HPV)-positive women in cervical screening programs; however, prospective data comparing the natural history and carcinogenic potential of individual HR types remain limited. A meta-analysis of cross-sectional HR HPV-type distribution in 115,789 HPV-positive women was performed, including 33,154 normal cytology, 6,810 atypical squamous cells of undetermined significance (ASCUS), 13,480 low-grade squamous intraepithelial lesions (LSIL) and 6,616 high-grade SIL (HSIL) diagnosed cytologically, 8,106 cervical intraepithelial neoplasia grade 1 (CIN1), 4,068 CIN2 and 10,753 CIN3 diagnosed histologically and 36,374 invasive cervical cancers (ICCs) from 423 PCR-based studies worldwide. No strong differences in HPV-type distribution were apparent between normal cytology, ASCUS, LSIL or CIN1. However, HPV16 positivity increased steeply from normal/ASCUS/LSIL/CIN1 (20-28%), through CIN2/HSIL (40/47%) to CIN3/ICC (58/63%). HPV16, 18 and 45 accounted for a greater or equal proportion of HPV infections in ICC compared to normal cytology (ICC:normal ratios = 3.07, 1.87 and 1.10, respectively) and to CIN3 (ICC:CIN3 ratios = 1.08, 2.11 and 1.47, respectively). Other HR types accounted for important proportions of HPV-positive CIN2 and CIN3, but their contribution dropped in ICC, with ICC:normal ratios ranging from 0.94 for HPV33 down to 0.16 for HPV51. ICC:normal ratios were particularly high for HPV45 in Africa…
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Distribution of most common genotypes in ICC cases is also consistent with the types found worldwide.
“Distribution of most common genotypes in ICC cases is also consistent with the types found in worldwide [26, 27].”
From HPV Genotypes distribution in Indian women with and without cervical carcinoma: Implication for HPV vaccination program in Odisha, Eastern India (2017) · cites this paper as [27]
Approximately more than 70% of worldwide invasive cervical cancer could be prevented by the available bivalent and quadrivalent HPV vaccines.
“Approximately, more than 70% worldwide ICC could be prevented by the available bivalent HPV vaccines-CervarixTM (GlaxoSmithKline Biologicals, Rixensart, Belgium) and quadrivalent HPV vaccine- Gardasil® (4vHPV) (Merck & Co., Inc., Kenilworth, NJ, USA) [26, 27].”
From HPV Genotypes distribution in Indian women with and without cervical carcinoma: Implication for HPV vaccination program in Odisha, Eastern India (2017) · cites this paper as [27]
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Carcinogenic human papillomavirus infection
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“Distribution of most common genotypes in ICC cases is also consistent with the types found in worldwide [26, 27].”
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Human papillomavirus vaccination at a time of changing sexual behavior
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- Authors
- Guan, P., Howell‐Jones, R., Li, N., Bruni, L., de Sanjosé, S., Franceschi, S., & Clifford, G. M.
- Affiliations
- Centre international de recherche sur le cancer (FR)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Institut Català d'Oncologia (ES)
- Corresponding author
- Clifford, Gary M.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2012-03-20
- Volume
- 131
- Issue
- 10
- Pages
- 2349-2359
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2020386919
- Cited by
- 927
- References
- 1
- Citations by year
- 2026: 35 · 2025: 53 · 2024: 70 · 2023: 67 · 2022: 79 · 2021: 83 · 2020: 74 · 2019: 71 · 2018: 62 · 2017: 55 · 2016: 75 · 2015: 61 · 2014: 62 · 2013: 54 · 2012: 23
- FWCI
- 7.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- International Journal of Cancer (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Fondation Innovations en Infectiologie
- National Institute for Health and Care Research
- Topics
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Keywords
- human papillomavirus, HPV genotyping, high-risk HPV, HPV16, HPV 18, HPV45, cervical intraepithelial neoplasia, cervical cancer, ASCUS, low-grade squamous intraepithelial lesion, high-grade squamous intraepithelial lesion, natural history of HPV infection, HPV-based screening, risk stratification, HPV58
- MeSH terms
- Uterine Cervical Dysplasia, Uterine Cervical Neoplasms, Cervix Uteri, Female, Genotype, Humans, Prevalence, Papillomaviridae, Papillomavirus Infections
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