Diagnostic value of fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography for the detection of metastases in non-small-cell lung cancer patients

Wu, Yihua; Li, Peiwei; Zhang, Honghe; Shi, Yu; Wu, Han; Zhang, Jinjie; Qian, Yufeng; Li, Chao; Yang, Jun

doi:10.1002/ijc.27779

Cited by 129Lung Cancer Diagnosis and TreatmentMedical Imaging Techniques and ApplicationsCancer Diagnosis and Treatment

Diagnostic value of fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography for the detection of metastases in non-small-cell lung cancer patients

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Wu, Yihua, Li, Peiwei, Zhang, Honghe, Shi, Yu, Wu, Han, Zhang, Jinjie, Qian, Yufeng, Li, Chao +1 more·2013·International Journal of Cancer

DOI 10.1002/ijc.27779

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Abstract

In the recent years, fluorine 18 fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET)/computed tomography (CT) has emerged as a new modality for staging non-small-cell lung cancer (NSCLC) patients. The aim of this meta-analysis was to assess the diagnostic value of (18)F-FDG PET/CT in detecting metastatic lesions in NSCLC patients. Meta-analysis methods were used to pool sensitivity, specificity, positive and negative likehood ratios, diagnostic odd ratios and to construct a summary receiver-operating characteristic curve. Data from included studies were pooled to compare the diagnostic accuracy between PET/CT and PET or CT alone in nodal staging. Totally, 56 studies involving 8,699 patients met the inclusion criteria. The pooled sensitivities and specificities of (18)F-FDG PET/CT were 0.72 [95% confidence interval (CI): 0.65-0.78] and 0.91 (95% CI: 0.86-0.94) in determining mediastinal nodal staging; 0.71 (95% CI: 0.60-0.80) and 0.83 (95% CI: 0.77-0.88) in intrathoracic staging; 0.78 (95% CI: 0.64-0.87) and 0.90 (95% CI: 0.84-0.94) in intrathoracic staging on a per-node basis. For detecting extrathoracic metastases, the pooled sensitivities and specificities of (18)F-FDG PET/CT were 0.77 (95% CI: 0.47-0.93) and 0.95 (95% CI: 0.92-0.97) for all extrathoracic metastases; 0.91 (95% CI: 0.80-0.97) and 0.98 (95% CI: 0.94-0.99) for bone metastases. (18)F-FDG PET/CT is beneficial in detecting lymph node metastases and extrathoracic metastases although PET/CT showed low sensitivity in detecting brain metastases. (18)F-FDG PET/CT confers significantly higher sensitivity and specificity than contrast-enhanced CT (both p < 0.01) and higher sensitivity than (18)F-FDG PET in staging NSCLC (p < 0.05).

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PET/CT is the most sensitive modality for detecting bone metastasis.
“PET/CT is the most sensitive modality in detecting bone metastasis [33].”
From Metastatic non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (2016) · cites this paper as [33]

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Lee, S. H., Min, J.-W., Lee, C. H., Park, C. M., Goo, J. M., Chung, D. H., Kang, C. H., Kim, Y. T., Kim, Y. W., Han, S. K., et al. (2010) · Journal of Korean Medical Science · doi:10.3346/jkms.2011.26.1.67 · Cited by 24 · see citing works
Evaluation of Adrenal Masses in Lung Cancer Patients Using F-18 FDG PET/CT
Cho, A. R., Lim, I., Na, I. I., Choe, D. H., Park, J. Y., Kim, B. I., Cheon, G. J., Choi, C. W., & Lim, S. M. (2010) · Nuclear Medicine and Molecular Imaging · doi:10.1007/s13139-010-0064-6 · Cited by 20 · see citing works
Mediastinal Lymph Node Staging by Means of Positron Emission Tomography Is Less Sensitive in Elderly Patients with Non-Small-Cell Lung Cancer
Al-Sarraf, N., Gately, K. A., Lucey, J. A., Wilson, L., McGovern, E., & Young, V. (2008) · Clinical Lung Cancer · doi:10.3816/clc.2008.n.007 · Cited by 15 · see citing works
Detection of nodal metastatic disease in patients with non-small cell lung cancer: comparison of positron emission tomography (PET), contrast-enhanced computed tomography (CT), and combined PET-CT
Ventura, E., Islam, T., Gee, M. S., Mahmood, U., Braschi, M., & Harisinghani, M. G. (2010) · Clinical Imaging · doi:10.1016/j.clinimag.2009.03.012 · Cited by 13 · see citing works
FDG PET/CT and Mediastinal Nodal Metastasis Detection in Stage T1 Non-Small Cell Lung Cancer: Prognostic Implications
Shin, K. M., Lee, K. S., Shim, Y. M., Kim, J., Kim, B. T., Kwon, O. J., & Park, K. (2008) · Korean Journal of Radiology · doi:10.3348/kjr.2008.9.6.481 · Cited by 13 · see citing works
Integrated Positron-Emission Tomography for Nodal Staging in Lung Cancer
Lee, H. J., Kim, Y. T., Kang, W. J., Lee, H. J., Kang, C. H., & Kim, J. H. (2009) · Asian Cardiovascular and Thoracic Annals · doi:10.1177/0218492309349253 · Cited by 11 · see citing works
[Significance of dual-time-point 18F-FDG PET imaging in evaluation of hilar and mediastinal lymph node metastasis in non-small-cell lung cancer].
Hu, M., Yu, J., Liu, N.-B., Liu, L., Guo, H., Yang, G.-R., Zhang, P., & Xu, X. (2008) · PubMed · Cited by 8 · see citing works
[Evaluation of the diagnostic value of (18)F-FDG PET-CT and enhanced CT for staging of lymph node metastasis in non-small cell lung cancer].
Yang, W., Tan, G.-Z., Fu, Z., & Yu, J. (2009) · PubMed · Cited by 8 · see citing works
[Value of positron emission tomography-computed tomography in the diagnosis of mediastinal lymph node metastasis of non-small cell lung cancer].
Xd, L., Jl, Y., Liu, W.-K., Xi, O., Zhou, Z., Gb, Q., & Zhang, J.-R. (2010) · PubMed · Cited by 6 · see citing works
[18F]Fluorodeoxyglucose positron emission tomography-computerized tomography and lung cancer: a significant referral bias exists
Okereke, I. C., Gangadharan, S. P., Kent, M. S., Nicotera, S. P., & DeCamp, M. M. (2010) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/j.ejcts.2010.07.039 · Cited by 4 · see citing works

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Sorted by citations

Metastatic non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Novello, S., Barlesi, F., Califano, R., Cufer, T., Ekman, S., Levra, M. G., Kerr, K., Popat, S., Reck, M., Senan, S., et al. (2016) · Annals of Oncology · doi:10.1093/annonc/mdw326 · Cited by 2,631 · see citing works
“PET/CT is the most sensitive modality in detecting bone metastasis [33].”
Background
Lung cancer
Thai, A. A., Solomon, B., Sequist, L. V. D., Gainor, J. F., & Heist, R. S. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00312-3 · Cited by 2,629 · see citing works
Metastatic non-small cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Planchard, D., Popat, S., Kerr, K., Novello, S., Smit, E. F., Faivre-Finn, C., Mok, T. S., Reck, M., Van Schil, P. E., Hellmann, M. D., et al. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy275 · Cited by 2,274 · see citing works
“PET-CT is the most sensitive modality in detecting bone metastasis [II, B] [75].”
Metastatic non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Peters, S., Adjei, A. A., Gridelli, C., Reck, M., Kerr, K. M., & Felip, E. (2012) · Annals of Oncology · doi:10.1093/annonc/mds226 · Cited by 930 · see citing works
Metastatic non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Reck, M., Popat, S., Reinmuth, N., Ruysscher, D. D., Kerr, K. M., & Peters, S. (2014) · Annals of Oncology · doi:10.1093/annonc/mdu199 · Cited by 679 · see citing works
Comparison of choline-PET/CT, MRI, SPECT, and bone scintigraphy in the diagnosis of bone metastases in patients with prostate cancer: a meta-analysis
Shen, G., Deng, H., Hu, S., & Jia, Z. (2014) · Skeletal Radiology · doi:10.1007/s00256-014-1903-9 · Cited by 361 · see citing works
Management of Stage III Non–Small-Cell Lung Cancer: ASCO Guideline
Daly, M. E., Singh, N., Ismaila, N., Antonoff, M. B., Arenberg, D. A., Bradley, J., David, E., Detterbeck, F., Früh, M., Gubens, M. A., et al. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.21.02528 · Cited by 297 · see citing works
“A MA of 56 studies including 8,699 patients demonstrated improved detection of occult metastasis with the use of integrated PET-CT scan compared with clinical staging without PET scan.(133) PET-CT scan, however, is not adequate to exclude CNS metastases, given the high obligate utilization of glucose by the brain.”
Background
Pan-Asian adapted Clinical Practice Guidelines for the management of patients with metastatic non-small-cell lung cancer: a CSCO–ESMO initiative endorsed by JSMO, KSMO, MOS, SSO and TOS
Wu, Y.-L., Planchard, D., Lü, S., Sun, H., Yamamoto, N., Kim, D., Tan, D. S.-W., Yang, J. C., Azrif, M., Mitsudomi, T., et al. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy554 · Cited by 292 · see citing works
Prognostic value of volumetric parameters of 18F-FDG PET in non-small-cell lung cancer: a meta-analysis
Im, H., Pak, K., Cheon, G. J., Kang, K. W., Kim, S., Kim, I.-J., Chung, J.-K., Kim, E. E., & Lee, D. S. (2014) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-014-2903-7 · Cited by 247 · see citing works
“[54] 2012 China 56 8,699 Staging Detection of metastasis Sensitivity/ specificity”
Background
Role of FDG PET/CT in the Eighth Edition of TNM Staging of Non–Small Cell Lung Cancer
Kandathil, A., Kay, F. U., Butt, Y. M., Wachsmann, J., & Subramaniam, R. M. (2018) · Radiographics · doi:10.1148/rg.2018180060 · Cited by 184 · see citing works
Imaging of lung cancer: Implications on staging and management
Purandare, N. C., & Rangarajan, V. (2015) · Indian journal of radiology and imaging - new series/Indian journal of radiology and imaging/Indian Journal of Radiology & Imaging · doi:10.4103/0971-3026.155831 · Cited by 140 · see citing works
“[19] A recent meta‐analysis, the largest till date on FDG PET in lung cancer which included 56 studies and approximately 8700 patients, showed a pooled sensitivity of 72% and specificity of 91% for mediastinal nodal disease.[21] Despite the high diagnostic accuracy of FDG PET for mediastinal nodal disease reported in…”
Background
Convolutional Neural Networks Promising in Lung Cancer T-Parameter Assessment on Baseline FDG-PET/CT
Kirienko, M., Sollini, M., Silvestri, G., Mognetti, S., Voulaz, E., Antunovic, L., Rossi, A., Antiga, L., & Chiti, A. (2018) · Contrast Media & Molecular Imaging · doi:10.1155/2018/1382309 · Cited by 88 · see citing works
The method and efficacy of support vector machine classifiers based on texture features and multi-resolution histogram from 18F-FDG PET-CT images for the evaluation of mediastinal lymph nodes in patients with lung cancer
Gao, X., Chu, C., Li, Y., Lu, P., Wang, W., Liu, W., & Yu, L. (2014) · European Journal of Radiology · doi:10.1016/j.ejrad.2014.11.006 · Cited by 87 · see citing works
“This analysis pattern was natural to our mental procedure and its diagnostic efficacy for mediastinal lymph nodes has been well established [1–4].”
BackgroundMethod
[18F]FDG-PET/CT Radiomics and Artificial Intelligence in Lung Cancer: Technical Aspects and Potential Clinical Applications
Manafi‐Farid, R., Askari, E., Shiri, I., Pirich, C., Asadi, M., Khateri, M., Zaidi, H., & Beheshti, M. (2022) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2022.04.004 · Cited by 73 · see citing works
The lung cancers: staging and response, CT, 18F-FDG PET/CT, MRI, DWI: review and new perspectives
Owens, C., Hindocha, S., Lee, R. W., Millard, T., & Sharma, B. (2023) · British Journal of Radiology · doi:10.1259/bjr.20220339 · Cited by 69 · see citing works
Therapeutic Potential of Denosumab in Patients With Lung Cancer: Beyond Prevention of Skeletal Complications
de Castro, J., García, R., Garrido, P., Isla, D., Massutí, B., Blanca, B., & Vázquez, J. (2015) · Clinical Lung Cancer · doi:10.1016/j.cllc.2015.06.004 · Cited by 52 · see citing works
The Diagnostic Value of MR Imaging in Determining the Lymph Node Status of Patients with Non–Small Cell Lung Cancer: A Meta-Analysis
Peerlings, J., Troost, E. G. C., Nelemans, P. J., Cobben, D., de Boer, J. C. J., Hoffmann, A. L., & Beets‐Tan, R. G. H. (2016) · Radiology · doi:10.1148/radiol.2016151631 · Cited by 49 · see citing works
Bone Metastases Are Measurable: The Role of Whole-Body MRI and Positron Emission Tomography
Oprea‐Lager, D. E., Cysouw, M. C. F., Boellaard, R., Deroose, C. M., de Geus‐Oei, L., Lopci, E., Bidaut, L. M., Herrmann, K., Fournier, L. S., Bäuerle, T., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.772530 · Cited by 49 · see citing works
Comparison of 18F-FDG PET/CT and DWI for detection of mediastinal nodal metastasis in non-small cell lung cancer: A meta-analysis
Shen, G., You, L., Zhang, K., Ren, P., & Jia, Z. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173104 · Cited by 48 · see citing works
An [18F]FDG-PET/CT deep learning method for fully automated detection of pathological mediastinal lymph nodes in lung cancer patients
Wallis, D., Soussan, M., Lacroix, M., Akl, P., Duboucher, C., & Buvat, I. (2021) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-021-05513-x · Cited by 41 · see citing works
“Wu et al. showed that using [18F]FDG-PET/CT for nodal staging of NSCLC confers significantly higher sensitivity and specificity than only contrast-enhanced CT and higher sensitivity than only [18F]FDG-PET [23].”
Method
Impact of 18F-FDG PET/CT, CT and EBUS/TBNA on preoperative mediastinal nodal staging of NSCLC
Al‐Ibraheem, A., Hirmas, N., Fanti, S., Páez, D., Abuhijla, F., Al-Rimawi, D., Al-Rasheed, U., Abdeljalil, R., Hawari, F. I., Al-Rabi, K. H., et al. (2021) · BMC Medical Imaging · doi:10.1186/s12880-021-00580-w · Cited by 40 · see citing works
PET/MRI and PET/CT in Lung Lesions and Thoracic Malignancies
Flechsig, P., Mehndiratta, A., Haberkorn, U., Kratochwil, C., & Giesel, F. L. (2015) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2015.03.004 · Cited by 37 · see citing works
In vivo Evaluation of Inflammatory Bowel Disease with the Aid of μPET and the Translocator Protein 18 kDa Radioligand [18F]DPA-714
Bernards, N., Pottier, G., Thezé, B., Dollé, F., & Boisgard, R. (2014) · Molecular Imaging and Biology · doi:10.1007/s11307-014-0765-9 · Cited by 36 · see citing works
“[(18)F]FDG is a glucose analog which indicates an increase of glucose consumption, which in itself can be indicative of other on-going processes such as cancer, cell regeneration, or muscle contraction as seen in peristalsis [23, 24].”
Background
Recent and Current Advances in FDG-PET Imaging within the Field of Clinical Oncology in NSCLC: A Review of the Literature
Kaseda, K. (2020) · Diagnostics · doi:10.3390/diagnostics10080561 · Cited by 34 · see citing works
“The pooled sensitivities and specificities of FDG-PET/CT for detecting all extrathoracic metastases have been reported to be 77% and 95%, respectively [73].”
Background
Personalised PET imaging in oncology: an umbrella review of meta-analyses to guide the appropriate radiopharmaceutical choice and indication
Kirienko, M., Gelardi, F., Fiz, F., Bauckneht, M., Ninatti, G., Pini, C., Briganti, A., Falconi, M., Oyen, W. J. G., van der Graaf, W. T. A., et al. (2024) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-024-06882-9 · Cited by 33 · see citing works
A Pilot Study of 18F-Alfatide PET/CT Imaging for Detecting Lymph Node Metastases in Patients with Non-Small Cell Lung Cancer
Zhou, Y., Gao, S., Huang, Y., Zheng, J., Dong, Y., Zhang, B., Zhao, S., Lu, H., Liu, Z., Yu, J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-03296-6 · Cited by 32 · see citing works
Association of maximum standardized uptake value with occult mediastinal lymph node metastases in cN0 non-small cell lung cancer
Lin, J., Yang, X., Zhong, W., Liao, R.-Q., Dong, S., Nie, Q., Weng, S.-X., Fang, X.-J., Zheng, J.-Y., & Wu, Y.-L. L. C. (2016) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezw109 · Cited by 31 · see citing works
“and specificity of MLN metastases are 72 and 91% [7], respectively, which means that some N2 diseases are not treated with optimal therapy.”
Background
Comparison of 18F-FDG PET/CT and 68Ga-FAPI-04 PET/CT in patients with non-small cell lung cancer
Can, C., Kepenek, F., Kömek, H., Gündoğan, C., Kaplan, İ., Taşdemir, B., Güzel, Y., Agüloğlu, N., & Karaoğlan, H. (2022) · Nuclear Medicine Communications · doi:10.1097/mnm.0000000000001607 · Cited by 30 · see citing works
Quantifying the rate and predictors of occult lymph node involvement in patients with clinically node-negative non-small cell lung cancer
Haque, W., Singh, A., Park, H. S., Teh, B. S., Butler, E. B., Zeng, M., Lin, S. H., Welsh, J. W., Chang, J. Y., & Verma, V. (2021) · Acta Oncologica · doi:10.1080/0284186x.2021.2012253 · Cited by 29 · see citing works
Diagnostic performance of whole-body SPECT/CT in bone metastasis detection using 99mTc-labelled diphosphate: a systematic review and meta-analysis
Alqahtani, M. M., Fulton, R., CONSTABLE, C. J., Willowson, K. P., & Kench, P. L. (2020) · Clinical Radiology · doi:10.1016/j.crad.2020.07.026 · Cited by 28 · see citing works
Diagnostic Value of 18 F-FDG PET/CT in Comparison to Bone Scintigraphy, CT and 18 F-FDG PET for the Detection of Bone Metastasis
Liu, N., Zhu, L., Li, M., Sun, X., Hu, M., Huo, Z.-W., Xu, W., & Yu, J. (2013) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2013.14.6.3647 · Cited by 26 · see citing works
“With tracer accumulation 18F-FDG PET visualizes regions of enhanced metabolic activity and complements other imaging modalities based on structural anatomic changes (Wu et al., 2013).”
Method
FDG PET/CT for Primary Staging of Lung Cancer and Mesothelioma
Kandathil, A., & Subramaniam, R. M. (2022) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2022.04.011 · Cited by 26 · see citing works
Detection of Osseous Metastasis by 18F-NaF/18F-FDG PET/CT Versus CT Alone
Sampath, S. C., Sampath, S. C., Mosci, C., Lutz, A. M., Willmann, J. K., Mittra, E., Gambhir, S. S., & Iagaru, A. H. (2014) · Clinical Nuclear Medicine · doi:10.1097/rlu.0000000000000560 · Cited by 25 · see citing works
Multi-technique imaging of bone metastases: spotlight on PET-CT
Azad, G. K., & Cook, G. (2016) · Clinical Radiology · doi:10.1016/j.crad.2016.01.026 · Cited by 24 · see citing works
Dynamic FDG-PET imaging for differentiating metastatic from non-metastatic lymph nodes of lung cancer
Wumener, X., Zhang, Y., Wang, Z., Zhang, M., Zang, Z., Huang, B., Liu, M., Huang, S., Huang, Y., Wang, P., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1005924 · Cited by 23 · see citing works
Lung Cancer Staging: Imaging and Potential Pitfalls
Erasmus, L. T., Strange, T. A., Agrawal, R., Strange, C. D., Ahuja, J., Shroff, G. S., & Truong, M. T. (2023) · Diagnostics · doi:10.3390/diagnostics13213359 · Cited by 22 · see citing works
State of the Art MR Imaging for Lung Cancer TNM Stage Evaluation
Ohno, Y., Ozawa, Y., Koyama, H., Yoshikawa, T., Takenaka, D., Nagata, H., Ueda, T., Ikeda, H., & Toyama, H. (2023) · Cancers · doi:10.3390/cancers15030950 · Cited by 21 · see citing works
Upfront surgery in patients with clinical skip N2 lung cancer based on results of modern radiological examinations
Maniwa, T., Shintani, Y., Okami, J., Kadota, Y., Takeuchi, Y., Takami, K., Yokouchi, H., Kurokawa, E., Kanzaki, R., Sakamaki, Y., et al. (2018) · Journal of Thoracic Disease · doi:10.21037/jtd.2018.10.115 · Cited by 18 · see citing works
“The criterion for lymph node positivity was the shortest nodal diameter of ≥10 mm on CT (11) or a metabolic activity of nodes higher than that of adjacent normal mediastinal and soft tissue on PET (12).”
Background
Diagnostic impact of integrated 18F-FDG PET/MRI in cerebral staging of patients with non-small cell lung cancer
Deuschl, C., Nensa, F., Grueneisen, J. S., Poeppel, T. D., Sawicki, L. M., Heusch, P., Gramsch, C., Mönninghoff, C., Quick, H. H., Forsting, M., et al. (2016) · Acta Radiologica · doi:10.1177/0284185116681041 · Cited by 16 · see citing works
“Whereas in whole-body staging, many studies and a metaanalysis of 8699 patients demonstrated significant higher sensitivity and specificity of PET/CT in patients with NSCLC compared to contrast-enhanced CT or PET alone (20).”
Background
Mediastinal staging of nonsmall cell lung cancer: what's new?
Bradley, C., Novoa, N. M., Riva, L., Lampaki, S., Ricciardi, S., Rovanias, M., Chaabouni, M., Turner, R. D., Zachariou, A., Hardavella, G. F., et al. (2025) · Breathe · doi:10.1183/20734735.0191-2023 · Cited by 15 · see citing works
“FDG PET-CT has a higher sensitivity and specificity than CT [26, 27], providing information on the biological and metabolic behaviour of lymph nodes based on the avidity of FDG uptake.”
FDG PET/CT for Staging Lung Carcinoma: An Update
Sathekge, C., Maes, J., Maes, A., & de Wiele, C. V. (2025) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2025.01.002 · Cited by 15 · see citing works
Emerging Role of MRI for Radiation Treatment Planning in Lung Cancer
Cobben, D., de Boer, H. C. J., Tijssen, R. H. N., Rutten, E. G. G. M., van Vulpen, M., Peerlings, J., Troost, E. G. C., Hoffmann, A. L., & van Lier, A. L. H. M. W. (2015) · Technology in Cancer Research & Treatment · doi:10.1177/1533034615615249 · Cited by 14 · see citing works
Multidisciplinary expert opinion on the treatment consensus for patients with EGFR mutated NSCLC with brain metastases
Ponce, S., Bruna, J., Juan, Ó., Castro, R. L., Navarro, A., Granados, A. L. O., Puente, J., Verger, E., Bartolomé, A. G., & Nadal, E. (2019) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2019.03.017 · Cited by 14 · see citing works
True abscopal effect in a patient with metastatic non-small cell lung cancer
Vilinovszki, O., Andratschke, N. H., Huellner, M. W., Fontecedro, A. C., & Kroeze, S. G. C. (2021) · Radiation Oncology · doi:10.1186/s13014-021-01920-4 · Cited by 14 · see citing works
“(18)F-FDG PET/CT imaging has an excellent specificity (98%) for the detection of bone metastases of non-small cell lung cancer [17, 18] and our patient had no other potential cause for the initially observed FDG-avidity in the vertebrae, such as a fracture, trauma, inflammation or recent cancer treatment.”
Background
Machine learning classification of mediastinal lymph node metastasis in NSCLC: a multicentre study in a Western European patient population
Laros, S. S. A., Dieckens, D., Blazis, S. P., & van der Heide, J. A. (2022) · EJNMMI Physics · doi:10.1186/s40658-022-00494-8 · Cited by 13 · see citing works
MRI-based differentiation between lymphoma and sarcoidosis in mediastinal lymph nodes
Santos, F. D. S., Verma, N., Marchiori, E. D. S., Watte, G., Medeiros, T. M., Mohammed, T.-L. H., & a, B. H. (2021) · Jornal Brasileiro de Pneumologia · doi:10.36416/1806-3756/e20200055 · Cited by 13 · see citing works
Diagnostic value of endobronchial ultrasound elastography in differentiating between benign and malignant hilar and mediastinal lymph nodes: a retrospective study
Wang, Y., Zhao, Z., Zhu, M., Zhu, Q., Yang, Z., & Chen, L. (2023) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims-23-241 · Cited by 12 · see citing works
“Positron emission tomography (PET)/CT has been shown to be more accurate than CT with a sensitivity of 72% and a specificity of 91% for mediastinal nodal staging (2).”
Dual time point imaging for F18-FDG-PET/CT does not improve the accuracy of nodal staging in non-small cell lung cancer patients
Rogasch, J. M. M., Steffen, I. G., Riedel, S., Apostolova, I. I., Wertzel, H., Achenbach, H. J., Steinkrüger, F. L. G. A., Kalinski, T., Schultz, M., Schreiber, J., et al. (2015) · European Radiology · doi:10.1007/s00330-015-4093-5 · Cited by 12 · see citing works
“However, recent metaanalyses on the diagnostic performance of established PET scanners (bismuth germanate [BGO] crystals and standard ordered subset expectation maximization [OSEM] reconstruction) for mediastinal LN staging in NSCLC showed highly variable sensitivities of only 72 to 84 % as well as specificities of 79…”
Background
When Should 99mTc Bone Scintigraphy Be Performed in cT1N0 Non-Small Cell Lung Cancer Patients?
Li, H., Hu, H., Wang, R., Zhang, Y., Xiang, J., Liu, Q., Shi, W., Sun, Y., & Chen, H. (2015) · Medicine · doi:10.1097/md.0000000000002309 · Cited by 11 · see citing works
Imaging of Oligometastatic Disease
Violi, N. V., Hajri, R., Haefliger, L., Lalonde, M. N., Villard, N., & Dromain, C. (2022) · Cancers · doi:10.3390/cancers14061427 · Cited by 11 · see citing works
“A meta-analysis of 56 studies evaluating the diagnostic value of 18F-FDG PET in patients with NSCLC showed a significantly higher performance of 18F-FDG PET/CT over CECT with pooled sensitivities and specificities of 72% and 91%, respectively, in determining mediastinal nodal staging, 77% and 95% respectively for dete…”
Method
Imaging of Lung Cancer Staging
Archer, J. M., Truong, M. T., Shroff, G. S., Godoy, M. C. B., & Marom, E. M. (2022) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0042-1753476 · Cited by 11 · see citing works
Surgery versus radiotherapy in octogenarians with stage Ia non‑small cell lung cancer: propensity score matching analysis of the SEER database
Ni, L., Lin, G., Zhang, Z., Sun, D., Liu, Z., & Liu, X. (2022) · BMC Pulmonary Medicine · doi:10.1186/s12890-022-02177-7 · Cited by 11 · see citing works
PET/MRI in Lung Cancer
Fan, L., Sher, A. C., Kohan, A. A., Vercher-Conejero, J. L., & Rajiah, P. S. (2014) · Seminars in Roentgenology · doi:10.1053/j.ro.2014.07.002 · Cited by 10 · see citing works
“%) for mediastinal lymph node staging in patients with NSCLC.56,57 However, PET/CT has high false-positive results owing to inflammation or granulomas, resulting in a high negative predictive value.47 Recent studies showed that DWI is superior to PET/CT in N staging of NSCLC.”
BackgroundInfluential
Skeletal Metastasis Evaluation
Broski, S. M., Young, J. R., Kendi, A. T., & Subramaniam, R. M. (2018) · PET Clinics · doi:10.1016/j.cpet.2018.08.006 · Cited by 10 · see citing works
[18F]Fluorodeoxyglucose PET in Thoracic Malignancies
Vilstrup, M. H., & Torigian, D. A. (2014) · PET Clinics · doi:10.1016/j.cpet.2014.06.002 · Cited by 10 · see citing works
Management of Early-Stage Resected Non-Small Cell Lung Cancer: Consensus Statement of the Lung cancer Consortium
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Authors: Wu, Y., Li, P., Zhang, H., Shi, Y., Wu, H., Zhang, J., Qian, Y., Li, C., & Yang, J.
Affiliations: Zhejiang University (CN)
Hangzhou Normal University (CN)
Corresponding author: Yang, Jun
ORCID: Wu, Yihua
Li, Peiwei
Zhang, Honghe
Shi, Yu
Wu, Han
Zhang, Jinjie
Qian, Yufeng
Li, Chao
Yang, Jun
Venue: International Journal of Cancer
Publisher: Wiley
Published: 2012-09
Volume: 132
Issue: 2
Pages: E37-47
ISSN: 0020-7136 (ISSN-L)
1097-0215
DOI: 10.1002/ijc.27779
OpenAlex: W2021499674
Cited by: 129
References: 78
Citations by year: 2026: 5 · 2025: 7 · 2024: 7 · 2023: 12 · 2022: 16 · 2021: 19 · 2020: 5 · 2019: 11 · 2018: 9 · 2017: 7 · 2016: 6 · 2015: 12 · 2014: 8 · 2013: 4 · 2012: 1
FWCI: 1.35
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: International Journal of Cancer (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Health Sciences › Medicine › Oncology › Cancer Diagnosis and Treatment
Keywords: 18F-FDG PET/CT, non-small cell lung cancer, metastasis detection, lymph node staging, mediastinal lymph nodes, bone metastasis, extrathoracic metastases, diagnostic accuracy, sensitivity and specificity, tumor staging, diagnostic odds ratio, summary receiver operating characteristic
MeSH terms: Bone Neoplasms, Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Humans, Lung Neoplasms, Lymphatic Metastasis, Neoplasm Staging, ROC Curve, Tomography, X-Ray Computed, Radiopharmaceuticals, Fluorodeoxyglucose F18, Positron-Emission Tomography, Multimodal Imaging

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Diagnostic value of fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography for the detection of metastases in non-small-cell lung cancer patients

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