Cited by 114Histone Deacetylase Inhibitors ResearchEnzyme function and inhibitionEpigenetics and DNA Methylation

HDAC11 is a novel drug target in carcinomas

Deubzer, Hedwig E., Schier, Marie C., Oehme, Ina, Lodrini, Marco, Haendler, Bernard, Sommer, Anette, Witt, Olaf·2013·International Journal of Cancer

Abstract

Inhibition of histone deacetylase (HDAC) activity as stand-alone or combination therapy represents a promising therapeutic approach in oncology. The pan- or class I HDAC inhibitors (HDACi) currently approved or in clinical studies for oncology give rise to dose-limiting toxicities, presumably because of the inhibition of several HDACs. This could potentially be overcome by selective blockade of single HDAC family members. Here we report that HDAC11, the most recently identified zinc-dependent HDAC, is overexpressed in several carcinomas as compared to corresponding healthy tissues. HDAC11 depletion is sufficient to cause cell death and to inhibit metabolic activity in HCT-116 colon, PC-3 prostate, MCF-7 breast and SK-OV-3 ovarian cancer cell lines. The antitumoral effect induced can be mimicked by enforced expression of a catalytically impaired HDAC11 variant, suggesting that inhibition of the enzymatic activity of HDAC11 by small molecules could trigger the desired phenotypic changes. HDAC11 depletion in normal cells causes no changes in metabolic activity and viability, strongly suggesting that tumor-selective effects can be achieved. Altogether, our data show that HDAC11 plays a critical role in cancer cell survival and may represent a novel drug target in oncology.

Integrity signals

Registry

Crossref · 10.1002/ijc.27876

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • HDAC11 expression is upregulated in multiple carcinomas compared to healthy counterparts.

    “As reported for other HDACs, HDAC11 expression is upregulated in multiple carcinomas compared to healthy counterparts (Deubzer et al., 2012;Gong, Zeng, Yi, & Wu, 2019;Liu, Wu, Jin, Chang, & Xu, 2020).”

    From HDACs and the epigenetic plasticity of cancer cells: target the complexity (2022) · cites this paper as Deubzer et al., 2012

Cites

Flagged first, then by citations

1 of the 29 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Deubzer, H. E., Schier, M. C., Oehme, I., Lodrini, M., Haendler, B., Sommer, A., & Witt, O.
Affiliations
  • German Cancer Research Center (DE)
  • Bayer (Germany) (DE)
Corresponding author
Deubzer, Hedwig E.
Venue
International Journal of Cancer
Publisher
Wiley
Published
2012-10-25
Volume
132
Issue
9
Pages
2200-2208
ISSN
  • 0020-7136 (ISSN-L)
  • 1097-0215
OpenAlex
W2082426890
Cited by
112
References
29
Citations by year
2026: 5 · 2025: 3 · 2024: 9 · 2023: 9 · 2022: 7 · 2021: 15 · 2020: 10 · 2019: 11 · 2018: 3 · 2017: 9 · 2016: 10 · 2015: 10 · 2014: 7 · 2013: 4
FWCI
2.70
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Enzyme function and inhibition
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords
HDAC11, histone deacetylase, carcinoma, tumor cell survival, colon cancer, prostate cancer, breast cancer, ovarian cancer, metabolic activity, therapeutic target
MeSH terms
Cells, Cultured, Flow Cytometry, Histone Deacetylases, Humans, Neoplasms, RNA, Messenger, Blotting, Western, Apoptosis, Reverse Transcriptase Polymerase Chain Reaction, Mammary Glands, Human, Cell Proliferation, Caspase 3, Small Molecule Libraries, Histone Deacetylase Inhibitors, Real-Time Polymerase Chain Reaction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review