The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Mixed‐polarization phenotype of ascites‐associated macrophages in human ovarian carcinoma: Correlation of CD163 expression, cytokine levels and early relapse
Open accessAbstract
Ovarian cancer is typically accompanied by the occurrence of malignant ascites containing large number of macrophages. It has been suggested that these tumor‐associated macrophages (TAMs) are skewed to alternative polarization (M2) and thereby play an essential role in therapy resistance and metastatic spread. In our study, we have investigated the nature, regulation and clinical correlations of TAM polarization in serous ovarian cancer. Macrophage polarization markers on TAMs and ascites cytokine levels were analyzed for 30 patients and associated with relapse‐free survival (RFS) in a prospective study with 20 evaluable patients. Surface expression of the M2 marker CD163 on TAMs was inversely associated with RFS (p < 0.01). However, global gene expression profiles determined for 17 of these patients revealed a mixed‐polarization phenotype unrelated to the M1/M2 classification. CD163 surface expression also correlated with the ascites levels of IL‐6 and IL‐10 (p < 0.05), both cytokines induced CD163 expression, and their ascites levels showed a clear inverse association with RFS (p < 0.01). These findings define a subgroup of patients with high CD163 expression, high IL‐6 and/or IL‐10 levels and poor clinical outcome.
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Coordinated regulation of myeloid cells by tumours
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Systematic validation of specific phenotypic markers for in vitro polarized human macrophages
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The Role of Tumor-Associated Macrophages in the Progression and Chemoresistance of Ovarian Cancer
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Tumor-derived exosomes in the regulation of macrophage polarization
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Metadata
- Authors
- Reinartz, S., Schumann, T., Finkernagel, F., Wortmann, A., Jansen, J. M., Meissner, W., Krause, M., Schwörer, A., Wagner, U., Müller‐Brüsselbach, S., & Müller, R.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2013-07-19
- Volume
- 134
- Issue
- 1
- Pages
- 32-42
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W1509070276
- Cited by
- 271
- References
- 5
- FWCI
- 7.24
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Reinartz, S., Schumann, T., Finkernagel, F., Wortmann, A., Jansen, J. M., Meissner, W., Krause, M., Schwörer, A., Wagner, U., Müller‐Brüsselbach, S., & Müller, R. (2014). Mixed‐polarization phenotype of ascites‐associated macrophages in human ovarian carcinoma: Correlation of CD163 expression, cytokine levels and early relapse. International Journal of Cancer. https://doi.org/10.1002/ijc.28335
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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