Cited by 248Oral Health Pathology and TreatmentHead and Neck Cancer StudiesHIV/AIDS oral health manifestations

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Potentially malignant disorders of the oral cavity: Current practice and future directions in the clinic and laboratory

Dionne, Kalen R., Warnakulasuriya, Saman, Binti Zain, Rosnah, Cheong, Sok Ching·2015·International Journal of Cancer

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Abstract

Despite commendable progress in the prevention, detection, and treatment of a wide variety of solid tumor types, oral squamous cell carcinoma (OSCC) remains a significant health burden across the globe. OSCC carcinogenesis involves accumulation of genetic alterations that coincide with the multistep malignant transformation of normal oral epithelium. OSCC is often first diagnosed at late stages of the disease (advanced regional disease and/or metastasis). Delayed diagnosis precludes successful treatment and favorable outcomes. In clinical practice, opportunities exist to identify patients with oral potentially malignant disorders (OPMDs), which precede the development of cancer. This review addresses the current status of laboratory and clinical research on OPMDs, with emphasis on leukoplakia and erythroplakia. OSF is also presented, though there is a paucity of published studies on this disorder. We focus on findings that could translate into earlier diagnosis and more efficacious treatment of those lesions with significant malignant potential. We explore how markers of OPMD malignant transformation might be implemented into current diagnostic practice to help clinicians objectively stratify patients into treatment/follow‐up groups according to relative risk. We provide an overview of recently concluded and ongoing OPMD chemoprevention trials. We describe laboratory OPMD models that can be used to not only to reveal the genetic and molecular intricacies of oral cancer but also to develop novel screening methods and therapeutic approaches. Finally, we call for targeted screening programs of at‐risk populations in order to facilitate diagnosis and treatment of OPMD and early OSCC.

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Authors: Dionne, K. R., Warnakulasuriya, S., Binti Zain, R., & Cheong, S. C.
Affiliations: University of Malaya (MY)
King's College London (GB)
Faculty of Dentistry Oral Cancer Research and Co‐ordinating Centre (OCRCC), University of Malaya Kuala Lumpur Malaysia
Corresponding author: Cheong, Sok Ching
ORCID: Dionne, Kalen R.
Warnakulasuriya, Saman
Cheong, Sok Ching
Venue: International Journal of Cancer
Publisher: Wiley
Published: 2014-02-11
Volume: 136
Issue: 3
Pages: 503-515
ISSN: 0020-7136 (ISSN-L)
1097-0215
DOI: 10.1002/ijc.28754
OpenAlex: W2154220394
Cited by: 248
References: 160
Citations by year: 2026: 4 · 2025: 11 · 2024: 17 · 2023: 24 · 2022: 32 · 2021: 29 · 2020: 30 · 2019: 20 · 2018: 17 · 2017: 19 · 2016: 21 · 2015: 17 · 2014: 6
FWCI: 3.53
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: International Journal of Cancer (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Dentistry › General Dentistry › Oral Health Pathology and Treatment
Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
Health Sciences › Dentistry › General Dentistry › HIV/AIDS oral health manifestations
Keywords: oral potentially malignant disorders, oral squamous cell carcinoma, leukoplakia, erythroplakia, oral submucous fibrosis, chemoprevention, oral cancer screening, early diagnosis, oral carcinogenesis, oral epithelium, in vitro disease model
MeSH terms: Aged, Carcinoma, Squamous Cell, DNA, Humans, Leukoplakia, Oral, Male, Middle Aged, Mouth Neoplasms, Ploidies, Loss of Heterozygosity, Cyclin D1

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Potentially malignant disorders of the oral cavity: Current practice and future directions in the clinic and laboratory

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