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Cited by 271

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Low natural killer‐cell activity and immunoglobulin levels associated with smoking in human subjects

Ferson, M., Edwards, Anne, Lind, Anne, Milton, G. W., Hersey, P.·1979·International Journal of Cancer
DOI 10.1002/ijc.2910230504
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Abstract

Previous studies have shown that smoking is associated with a high incidence of certain malignancies and a high incidence of metastatic spread of melanoma. The purpose of the present study was to examine whether this high incidence of malignancy could be associated with certain aspects of immune function believed to be important in restricting tumour growth. Age‐and sex‐matched smoking and non‐smoking normal subjects and male, smoking and non‐smoking melanoma patients, were studied for the natural killing (NK) activity of their blood leukocytes against cultured melanoma and Chang cells. The levels of the various immunoglobulin classes in their sera and the E rosette levels of the normal subjects were also assessed. The results indicate that the NK activity of blood leukocytes from both normal subjects and melanoma patients who smoked was significantly lower against cultured melanoma cells than that of non‐smokers. Smokers were also shown to have lower IgG and IgA Immunoglobulin levels in their sera compared to non‐smokers but no differences in the percentage of E‐rosetting (T) cells was detected. Recent studies provide some basis for the belief that the low NK activity and immunoglobulin levels in smokers may be related. These results further suggest that a closer examination of the effects of this environmental hazard on the immune system and its relation to malignancy is needed.

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Metadata

Authors
Ferson, M., Edwards, A., Lind, A., Milton, G. W., & Hersey, P.
Venue
International Journal of Cancer
Publisher
Wiley
Published
1979-05-15
Volume
23
Issue
5
Pages
603-609
ISSN
  • 0020-7136 (ISSN-L)
  • 1097-0215
DOI
10.1002/ijc.2910230504
OpenAlex
W1982460203
Cited by
271
References
20
FWCI
2.88
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Low natural killer‐cell activity and immunoglobulin levels associated with smoking in human subjects. https://app.cochat.ai/papers/10.1002/ijc.2910230504
The paper
Ferson, M., Edwards, A., Lind, A., Milton, G. W., & Hersey, P. (1979). Low natural killer‐cell activity and immunoglobulin levels associated with smoking in human subjects. International Journal of Cancer. https://doi.org/10.1002/ijc.2910230504

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.