The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
The receptor encoded by the human C‐MET oncogene is expressed in hepatocytes, epithelial cells and solid tumors
Abstract
The human c‐MET oncogene encodes a transmembrane tyrosine kinase (p 190 c‐met) with structural and functional features of a growth‐factor receptor. Monoclonal antibodies (MAbs) have been used to investigate the distribution of the c‐Met protein in human normal and neoplastic tissues. By immunofluorescence microscopy homogeneous expression was detected in normal hepatocytes as well as in epithelial cells lining the stomach, the small and the large intestine. Positive staining was also found in epithelial cells of the endometrium and ovary, and in basal keratinocytes of esophagus and skin. By Northern blot analysis, high levels of c‐met messenger RNA were detected in specimens of liver, gastro‐intestinal tract and kidney. c‐met‐specific mRNA was also found in thyroid, pancreas and placenta, in which organs c‐Met protein was barely detectable by immunofluorescence. The antibodies revealed expression of c‐MET protein in hepatomas (11/14), carcinomas of colon and rectum (19/21), stomach (11/22), kidney (16/19), ovary (9/17) and skin (7/17). Carcinomas of the lung (13/20), thyroid (11/13) and pancreas (5/7) were also positive. In these last cases (lung, thyroid and pancreas) tumor cells were homogeneously stained by the antibodies, whereas in their normal counterparts staining was barely detectable. These data suggest that the receptor encoded by c‐MET plays a physiological role in epithelial cell growth and that its expression is altered in human carcinomas.
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Cited by
Bussolino, F., Di Renzo, M. F., Ziche, M., Bocchietto, E., Olivero, M., Naldini, L., Gaudino, G., Tamagnone, L., Coffer, A., & Comoglio, P. M. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.629 · Cited by 1,337
Self-citationNaldini, L., Tamagnone, L., Vigna, E., Sachs, M., Hartmann, G., Birchmeier, W., Daikuhara, Y., Tsubouchi, H., Blasi, F., & Comoglio, P. M. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05588.x · Cited by 565
Self-citationExpression of CD44 in Apc and TcfMutant Mice Implies Regulation by the WNT Pathway
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Induction of MET by Ionizing Radiation and Its Role in Radioresistance and Invasive Growth of Cancer
De Bacco, F., Luraghi, P., Medico, E., Reato, G., Girolami, F., Perera, T., Gabriele, P., Comoglio, P. M., & Boccaccio, C. (2011) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djr093 · Cited by 363
Self-citationMolecular mechanism of stomach carcinogenesis
Tahara, E. (1993) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/bf01212724 · Cited by 324
Metadata
- Authors
- Prat, M., Narsimhan, R. P., Crepaldi, T., Rita Nicotra, M., Natali, P. G., & Comoglio, P. M.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 1991-09-30
- Volume
- 49
- Issue
- 3
- Pages
- 323-328
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2087447167
- Cited by
- 287
- References
- 33
- FWCI
- 16.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Prat, M., Narsimhan, R. P., Crepaldi, T., Rita Nicotra, M., Natali, P. G., & Comoglio, P. M. (1991). The receptor encoded by the human C‐MET oncogene is expressed in hepatocytes, epithelial cells and solid tumors. International Journal of Cancer. https://doi.org/10.1002/ijc.2910490302
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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