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The role of HPV RNA transcription, immune response‐related gene expression and disruptive TP53 mutations in diagnostic and prognostic profiling of head and neck cancer
Open accessAbstract
Stratification of head and neck squamous cell carcinomas (HNSCC) based on HPV16 DNA and RNA status, gene expression patterns, and mutated candidate genes may facilitate patient treatment decision. We characterize head and neck squamous cell carcinomas (HNSCC) with different HPV16 DNA and RNA (E6*I) status from 290 consecutively recruited patients by gene expression profiling and targeted sequencing of 50 genes. We show that tumors with transcriptionally inactive HPV16 (DNA+ RNA‐) are similar to HPV‐negative (DNA‐) tumors regarding gene expression and frequency of TP53 mutations (47%, 8/17 and 43%, 72/167, respectively). We also find that an immune response‐related gene expression cluster is associated with lymph node metastasis, independent of HPV16 status and that disruptive TP53 mutations are associated with lymph node metastasis in HPV16 DNA‐ tumors. We validate each of these associations in another large data set. Four gene expression clusters which we identify differ moderately but significantly in overall survival. Our findings underscore the importance of measuring the HPV16 RNA (E6*I) and TP53‐mutation status for patient stratification and identify associations of an immune response‐related gene expression cluster and TP53 mutations with lymph node metastasis in HNSCC.
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Monti, S., Tamayo, P., Mesirov, J., & Golub, T. (2003) · Machine Learning · doi:10.1023/a:1023949509487 · Cited by 2,116
Molecular classification of head and neck squamous cell carcinomas using patterns of gene expression
Chung, C. H., Parker, J. S., Karaca, G., Wu, J., Funkhouser, W. K., Moore, D., Butterfoss, D., Xiang, D., Zanation, A., Yin, X., et al. (2004) · Cancer Cell · doi:10.1016/s1535-6108(04)00112-6 · Cited by 678
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Loss of Tumor Suppressor Gene Function in Human Cancer: An Overview
Wang, L.-H., Wu, C.-F., Rajasekaran, N., & Shin, Y. K. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000495956 · Cited by 334
Chen, T.-W., Lee, C.-C., Liu, H., Wu, C.-S., Pickering, C. R., Huang, P.-J., Wang, J., Chang, I. Y.-F., Yeh, Y.-M., Chen, C.-D., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00493-9 · Cited by 115
Zhao, Z., Li, Y., Wu, Y., & Chen, R. (2019) · Cancer Biomarkers · doi:10.3233/cbm-190380 · Cited by 23
Metadata
- Authors
- Wichmann, G., Rosolowski, M., Krohn, K., Kreuz, M., Boehm, A., Reiche, A., Scharrer, U., Halama, D., Bertolini, J., Bauer, U., Holzinger, D., Pawlita, M., Hess, J., Engel, C., Hasenclever, D., Scholz, M., Ahnert, P., Kirsten, H., Hemprich, A., Wittekind, C., Herbarth, O., Horn, F., Dietz, A., Loeffler, M., & for the Leipzig Head and Neck Group (LHNG)
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2015-07-06
- Volume
- 137
- Issue
- 12
- Pages
- 2846-2857
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2121937591
- Cited by
- 281
- References
- 2
- FWCI
- 13.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Wichmann, G., Rosolowski, M., Krohn, K., Kreuz, M., Boehm, A., Reiche, A., Scharrer, U., Halama, D., Bertolini, J., Bauer, U., Holzinger, D., Pawlita, M., Hess, J., Engel, C., Hasenclever, D., Scholz, M., Ahnert, P., Kirsten, H., Hemprich, A., . . . for the Leipzig Head and Neck Group (LHNG). (2015). The role of HPV RNA transcription, immune response‐related gene expression and disruptive TP53 mutations in diagnostic and prognostic profiling of head and neck cancer. International Journal of Cancer. https://doi.org/10.1002/ijc.29649
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
