The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Cytokine‐mediated blood brain barrier disruption as a conduit for cancer/chemotherapy‐associated neurotoxicity and cognitive dysfunction
Abstract
Neurotoxicity is a common side effect of chemotherapy treatment, with unclear molecular mechanisms. Clinical studies suggest that the most frequent neurotoxic adverse events affect memory and learning, attention, concentration, processing speeds and executive function. Emerging preclinical research points toward direct cellular toxicity and induction of neuroinflammation as key drivers of neurotoxicity and subsequent cognitive impairment. Emerging data now show detectable levels of some chemotherapeutic agents within the CNS, indicating potential disruption of blood brain barrier integrity or transport mechanisms. Blood brain barrier disruption is a key aspect of many neurocognitive disorders, particularly those characterized by a proinflammatory state. Importantly, many proinflammatory mediators able to modulate the blood brain barrier are generated by tissues and organs that are targets for chemotherapy‐associated toxicities. This review therefore aims to explore the hypothesis that peripherally derived inflammatory cytokines disrupt blood brain barrier permeability, thereby increasing direct access of chemotherapeutic agents into the CNS to facilitate neuroinflammation and central neurotoxicity.
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Cites
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Cited by
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BackgroundThe gut-brain axis: is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis?
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Mechanisms of Chemotherapy-Induced Neurotoxicity
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Chimeric Antigen Receptor T Cell–Mediated Neurotoxicity in Nonhuman Primates
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Stress-induced blood brain barrier disruption: Molecular mechanisms and signaling pathways
Welcome, M. O., & Mastorakis, N. E. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104769 · Cited by 139
Metadata
- Authors
- Wardill, H. R., Mander, K. A., Van Sebille, Y. Z. A., Gibson, R. J., Logan, R. M., Bowen, J. M., & Sonis, S. T.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2016-07-15
- Volume
- 139
- Issue
- 12
- Pages
- 2635-2645
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2468448692
- Cited by
- 174
- References
- 16
- FWCI
- 8.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wardill, H. R., Mander, K. A., Van Sebille, Y. Z. A., Gibson, R. J., Logan, R. M., Bowen, J. M., & Sonis, S. T. (2016). Cytokine‐mediated blood brain barrier disruption as a conduit for cancer/chemotherapy‐associated neurotoxicity and cognitive dysfunction. International Journal of Cancer. https://doi.org/10.1002/ijc.30252
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