Caveolae, caveolins, and cavins: complex control of cellular signalling and inflammation
Open accessAbstract
Caveolae are specialized lipid rafts that form flask-shaped invaginations of the plasma membrane. They are involved in cell signalling and transport and have been shown critically regulate vascular reactivity and blood pressure. The organization and functions of caveolae are mediated by coat proteins (caveolins) and support or adapter proteins (cavins). The caveolins, caveolin-1, -2, and -3, form the structural backbone of caveolae. These proteins are also highly integrated into caveolae function and have their own activity independent of caveolae. The cavins, cavins 1-4, are involved in regulation of caveolae and modulate the function of caveolins by promoting the membrane remodelling and trafficking of caveolin-derived structures. The relationships between these different proteins are complex and intersect with many aspects of cell function. Caveolae have also been implicated in chronic inflammatory conditions and other pathologies including atherosclerosis, inflammatory bowel disease, muscular dystrophy, and generalized dyslipidaemia. The pathogenic role of the caveolins is an emerging area, however, the roles of cavins in disease is just beginning to be explored. This review will examine the relationship between caveolins and cavins and explore the role of caveolae in inflammatory signalling mechanisms.
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Caveolin-1 (CAV1) is found in caveolae, cholesterol-rich membrane lipid formations that are involved in cholesterol traffic and homeostasis and regulation of inflammation.
“Caveolin-1 (CAV1) is found in caveolae, cholesterol-rich membrane lipid formations that are involved in cholesterol traffic and homeostasis58 and regulation of inflammation59 among other functions.”
From Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses (2016) · cites this paper as [59]
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- Authors
- Chidlow, J. H., & Sessa, W. C.
- Affiliations
- Yale University (US)
- Corresponding author
- Sessa, W. C.
- ORCID
- Sessa, W. C.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-03-03
- Volume
- 86
- Issue
- 2
- Pages
- 219-225
- ISSN
- 0008-6363 (ISSN-L)
- PMC
- PMC2856194
- OpenAlex
- W2131745475
- Cited by
- 310
- References
- 107
- Citations by year
- 2026: 12 · 2025: 15 · 2024: 12 · 2023: 14 · 2022: 12 · 2021: 21 · 2020: 16 · 2019: 15 · 2018: 24 · 2017: 17 · 2016: 17 · 2015: 22 · 2014: 26 · 2013: 26 · 2012: 33
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cardiovascular Research (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (HL61371, R01 HL61371)
- National Heart, Lung, and Blood Institute (P01HL070295, R01HL064793, R01-HL61371, P01 HL70295, R01HL057665, R01 HL64793, R01HL061371, R01-HL-57665)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Keywords
- caveolae, caveolin, caveolin-1, caveolin-2, caveolin-3, lipid rafts, membrane remodeling, vascular reactivity, blood pressure, signal transduction, inflammation, atherosclerosis, inflammatory bowel disease, muscular dystrophy, dyslipidemia
- MeSH terms
- Animals, Endothelium, Vascular, Humans, Inflammation, Signal Transduction, Inflammation Mediators, Caveolae, Caveolins, Intracellular Signaling Peptides and Proteins
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