The potential diagnostic value of serum microRNA signature in patients with pancreatic cancer
Open accessAbstract
Biomarkers for early diagnosis of patients with pancreatic cancer (PC) are needed. Our aim was to identify panels of miRNAs in serum in combination with CA 19‐9 for use in the diagnosis of PC. Four hundred seventeen patients with PC were included prospectively from Denmark (n = 306) and Germany (n = 111). Controls included 59 patients with chronic pancreatitis (CP) and 248 healthy subjects (HS). MiRNAs were analyzed in pretreatment serum samples from 3 cohorts: discovery cohort (754 human miRNAs, TaqMan® Human MicroRNA assay, Applied Biosystem; PC n = 133, controls n = 72); training cohort (34 miRNAs, real‐time qPCR using the Fluidigm BioMark™ System; PC n = 198, controls n = 184); validation cohort (13 miRNAs, real‐time qPCR using the Fluidigm BioMark™ System; PC n = 86, controls n = 51). We found that 34 miRNAs in serum from PC patients in the discovery cohort were expressed differently than in controls. These miRNAs were tested in the training cohort, and four diagnostic panels were constructed that included 5 or 12 miRNAs (miR‐16, −18a, −20a, −24, −25, −27a, −29c, −30a.5p, −191, −323.3p, −345 and −483.5p). Diagnostic accuracy of detecting PC in the training cohort was AUC (Index I 0.85; II 0.87; III 0.85; IV 0.95; CA 19‐9 0.93); specificity (I 0.71; II 0.76; III 0.66; IV 0.90 (fixed sensitivity at 0.85); CA 19‐9 0.93). Combining serum CA 19‐9 and Index II best discriminated Stages I and II PC from HS [AUC 0.93 (0.90–0.96), sensitivity 0.77 (0.69–0.84), specificity 0.94 (0.90–0.96) and accuracy 0.88 (0.84–0.91)]. In conclusion, we identified four diagnostic panels based on 5 or 12 miRNAs in serum that could distinguish patients with PC from HS and CP.
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- V C 2016 UICC 10970215, 2016, 10, Serum MicroRNA for Early Diagnosis of Pancreatic Cancer Int. J. Cancer: 139, 2312-2324 (2016) · DOI
- V C 2016 UICC 10970215, 2016, 10, Serum MicroRNA for Early Diagnosis of Pancreatic Cancer Int. J. Cancer: 139, 2312-2324 (2016) · DOI
- V C 2016 UICC 10970215, 2016, 10, bility for the integrity of the data and the accuracy of the data analysis. Conception and design: Julia S. Johansen, Dan Calatayud, Vanna Albieri, Nicolai A. Schultz, Christian Deh- lendorff, Klaus K. Andersen. Financial support: Julia S. Johansen, Benny V. Jensen. Administrative support: Julia S. Johansen, Benny V. Jensen, Klaus K. Andersen. Provision of study materials or patients: Julia S. Johansen, Dan Calatayud, Nicolai A. Schultz, Jens Werner, Benny V. Jensen, Per Pfeiffer, Stig E. Bojesen, Nathalia Giese, Kaspar R. Nielsen, Svend E. Nielsen, Mette Yilmaz, Niels H. Holl€ ander. Collec- tion and assembly of data: Julia S. Johansen, Dan Calatayud, Vanna Albieri, Nicolai A. Schultz, Christian Dehlendorff, Klaus K. Andersen. Data analysis and interpretation: Julia S. Johansen, Vanna Albieri, Dan Calatayud, Christian Dehlen- dorff, Nicolai A. Schultz, Klaus K. Andersen. Manuscript writing: Julia S. Johansen, Dan Calatayud, Vanna Albieri, Nicolai A. Schultz, Christian Dehlendorff, Klaus K. Andersen. Final approval of manuscript: all authors. References · DOI
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- Authors
- Johansen, J. S., Calatayud, D., Albieri, V., Schultz, N. A., Dehlendorff, C., Werner, J., Jensen, B. V., Pfeiffer, P., Bojesen, S. E., Giese, N., Nielsen, K. R., Nielsen, S. E., Yilmaz, M., Holländer, N. H., & Andersen, K. K.
- Affiliations
- Herlev Hospital (DK)
- Copenhagen University Hospital (DK)
- Danish Cancer Society (DK)
- Heidelberg University (DE)
- Odense University Hospital (DK)
- Aalborg University Hospital (DK)
- Nordsjællands Hospital (DK)
- Næstved Sygehus (DK)
- Corresponding author
- Johansen, Julia S.
- ORCID
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2016-08-16
- Volume
- 139
- Issue
- 10
- Pages
- 2312-2324
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2495300983
- Cited by
- 47
- References
- 42
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 2 · 2023: 7 · 2022: 7 · 2021: 5 · 2020: 7 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 1
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Cancer (publishedVersion)
- PubMed (publishedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
- Funders
- The Research Council at Herlev Hospital, Joint Proof-of-Concept Fund
- Ministry of Science, Technology and Innovation, Denmark
- Danish Cancer Society and Aase og Ejnar Danielsens Fond
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- pancreatic cancer, serum microRNA, microRNA signature, diagnostic biomarkers, CA19-9, early diagnosis, diagnostic accuracy, chronic pancreatitis, miR-16, miR-21, miR-20a, miR-24, miR-25, miR-27a, miR-29c, miR-30a-5p, miR-191, miR-345, miR-483-5p
- MeSH terms
- Humans, Pancreatic Neoplasms, Reproducibility of Results, Case-Control Studies, Carcinoma, Pancreatic Ductal, MicroRNAs, Pancreatitis, Chronic
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