Pancreatic adenocarcinoma
Abstract
Cancer of the pancreas is predominantly adenocarcinoma and involves activating KRAS mutations in the large majority of cases. Surgical resection can be effective in localized disease; combination chemotherapy offers some palliation in advanced disease.
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Mutations in CDKN2A, TP53, and SMAD4 enable early PanIN to progress to late PanIN and invasive PDAC.
“Acquisition of mutations in tumor suppressor genes CDKN2A, TP53, and SMAD4 enables early stage PanIN to progress to late stage PanIN and, ultimately invasive PDAC (2).”
From KRAS mutation in pancreatic cancer (2021) · cites this paper as [2]
Pancreatic cancer often harbors an immunosuppressive tumor microenvironment, making tumors refractory to immune checkpoint blockage using PD-1 and PD-L1 antibodies.
“Pancreatic cancer often harbors an immunosuppressive tumor microenvironment (2). As a result, these tumors are refractory to immune checkpoint blockage using PD-1 and PD-L1 antibodies.”
From KRAS mutation in pancreatic cancer (2021) · cites this paper as [2]
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- Authors
- Ryan, D. P., Hong, T. S., & Bardeesy, N.
- Affiliations
- Massachusetts General Hospital (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2014-09-11
- Volume
- 371
- Issue
- 11
- Pages
- 1039-1049
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4229719081
- Cited by
- 2,348
- References
- 72
- Citations by year
- 2026: 71 · 2025: 124 · 2024: 152 · 2023: 265 · 2022: 239 · 2021: 224 · 2020: 292 · 2019: 218 · 2018: 233 · 2017: 233 · 2016: 184 · 2015: 106 · 2014: 6
- FWCI
- 20.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
- Keywords
- pancreatic ductal adenocarcinoma, KRAS mutation, pancreatic cancer, surgical resection, combination chemotherapy, palliative care, advanced disease
- MeSH terms
- Adenocarcinoma, Antineoplastic Agents, Humans, Mutation, Neoplasm Metastasis, Neoplasm Staging, Pancreatic Neoplasms, Proto-Oncogene Proteins, Risk Factors, Proto-Oncogene Proteins p21(ras), Chemotherapy, Adjuvant, ras Proteins
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